Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1994 Mar;53(3):188–190. doi: 10.1136/ard.53.3.188

HLA-DP does not contribute towards susceptibility to systemic lupus erythematosus.

E J Davies 1, C J Hutchings 1, M C Hillarby 1, R P Donn 1, R G Cooper 1, E M Hay 1, R M Bernstein 1, P J Holt 1, D M Grennan 1, W E Ollier 1
PMCID: PMC1005284  PMID: 8154937

Abstract

OBJECTIVES--To determine whether HLA-DP genes are involved in determining susceptibility to systemic lupus erythematosus (SLE). METHODS--HLA-DPA1 and DPB1 genes were amplified by PCR of DNA samples from a panel of patients with SLE and normal controls. Amplified DNA was blotted on to nylon filters and probed with sequence-specific oligonucleotide (SSO) probes. RESULTS--No DPA1 or DPB1 allele was significantly associated with SLE, or with any immunological or clinical subset of SLE. Evidence was found for only limited linkage disequilibrium between HLA-DP and HLA-DQ/DR variants, and none between HLA-DP and the TAP2 gene. CONCLUSIONS--These data indicate that HLA-DP genes do not contribute towards determining susceptibility to SLE.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Batchelor J. R., Fielder A. H., Walport M. J., David J., Lord D. K., Davey N., Dodi I. A., Malasit P., Wanachiwanawin W., Bernstein R. Family study of the major histocompatibility complex in HLA DR3 negative patients with systemic lupus erythematosus. Clin Exp Immunol. 1987 Nov;70(2):364–371. [PMC free article] [PubMed] [Google Scholar]
  2. Davies E. J., Hillarby M. C., Cooper R. G., Hay E. M., Green J. R., Shah S., Bernstein R. M., Holt P. J., Grennan D. M. HLA-DQ, DR and complement C4 variants in systemic lupus erythematosus. Br J Rheumatol. 1993 Oct;32(10):870–875. doi: 10.1093/rheumatology/32.10.870. [DOI] [PubMed] [Google Scholar]
  3. Deapen D., Escalante A., Weinrib L., Horwitz D., Bachman B., Roy-Burman P., Walker A., Mack T. M. A revised estimate of twin concordance in systemic lupus erythematosus. Arthritis Rheum. 1992 Mar;35(3):311–318. doi: 10.1002/art.1780350310. [DOI] [PubMed] [Google Scholar]
  4. Fielder A. H., Walport M. J., Batchelor J. R., Rynes R. I., Black C. M., Dodi I. A., Hughes G. R. Family study of the major histocompatibility complex in patients with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility. Br Med J (Clin Res Ed) 1983 Feb 5;286(6363):425–428. doi: 10.1136/bmj.286.6363.425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Galeazzi M., Sebastiani G. D., Passiu G., Angelini G., Delfino L., Asherson R. A., Khamashta M. A., Hughes G. R. HLA-DP genotyping in patients with systemic lupus erythematosus: correlations with autoantibody subsets. J Rheumatol. 1992 Jan;19(1):42–46. [PubMed] [Google Scholar]
  6. Goldstein R., Sengar D. P. Comparative studies of the major histocompatibility complex in French Canadian and non-French Canadian Caucasians with systemic lupus erythematosus. Arthritis Rheum. 1993 Aug;36(8):1121–1127. doi: 10.1002/art.1780360813. [DOI] [PubMed] [Google Scholar]
  7. Howard P. F., Hochberg M. C., Bias W. B., Arnett F. C., Jr, McLean R. H. Relationship between C4 null genes, HLA-D region antigens, and genetic susceptibility to systemic lupus erythematosus in Caucasian and black Americans. Am J Med. 1986 Aug;81(2):187–193. doi: 10.1016/0002-9343(86)90250-0. [DOI] [PubMed] [Google Scholar]
  8. Hsu K. C., Hill D. L., Hoffman R. W. HLA-DPB1*0401 is associated with the presence of autoantibodies reactive with the U1-70 kD polypeptide antigen of U1-small nuclear ribonucleoprotein among connective tissue disease patients. Tissue Antigens. 1992 May;39(5):272–275. doi: 10.1111/j.1399-0039.1992.tb01947.x. [DOI] [PubMed] [Google Scholar]
  9. Kunkel L. M., Smith K. D., Boyer S. H., Borgaonkar D. S., Wachtel S. S., Miller O. J., Breg W. R., Jones H. W., Jr, Rary J. M. Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants. Proc Natl Acad Sci U S A. 1977 Mar;74(3):1245–1249. doi: 10.1073/pnas.74.3.1245. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Reveille J. D., Anderson K. L., Schrohenloher R. E., Acton R. T., Barger B. O. Restriction fragment length polymorphism analysis of HLA-DR, DQ, DP and C4 alleles in Caucasians with systemic lupus erythematosus. J Rheumatol. 1991 Jan;18(1):14–18. [PubMed] [Google Scholar]
  11. Reveille J. D., Brady J., MacLeod-St Clair M., Durban E. HLA-DPB1 alleles and autoantibody subsets in systemic lupus erythematosus, Sjögren's syndrome and progressive systemic sclerosis: a question of disease relevance. Tissue Antigens. 1992 Jul;40(1):45–48. doi: 10.1111/j.1399-0039.1992.tb01957.x. [DOI] [PubMed] [Google Scholar]
  12. Tan E. M., Cohen A. S., Fries J. F., Masi A. T., McShane D. J., Rothfield N. F., Schaller J. G., Talal N., Winchester R. J. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982 Nov;25(11):1271–1277. doi: 10.1002/art.1780251101. [DOI] [PubMed] [Google Scholar]
  13. Winchester R. J., Nunez-Roldan A. Some genetic aspects of systemic lupus erythematosus. Arthritis Rheum. 1982 Jul;25(7):833–837. doi: 10.1002/art.1780250724. [DOI] [PubMed] [Google Scholar]
  14. Yao Z., Hartung K., Deicher H. G., Brünnler G., Bettinotti M. P., Keller E., Paul C., Gawron C., Mikschl S., Albert E. DNA typing for HLA-DPB1-alleles in German patients with systemic lupus erythematosus using the polymerase chain reaction and DIG-ddUTP-labelled oligonucleotide probes. Members of SLE Study Group. Eur J Immunogenet. 1993 Aug;20(4):259–266. doi: 10.1111/j.1744-313x.1993.tb00141.x. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES