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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1994 Mar;53(3):188–190. doi: 10.1136/ard.53.3.188

HLA-DP does not contribute towards susceptibility to systemic lupus erythematosus.

E J Davies 1, C J Hutchings 1, M C Hillarby 1, R P Donn 1, R G Cooper 1, E M Hay 1, R M Bernstein 1, P J Holt 1, D M Grennan 1, W E Ollier 1
PMCID: PMC1005284  PMID: 8154937

Abstract

OBJECTIVES--To determine whether HLA-DP genes are involved in determining susceptibility to systemic lupus erythematosus (SLE). METHODS--HLA-DPA1 and DPB1 genes were amplified by PCR of DNA samples from a panel of patients with SLE and normal controls. Amplified DNA was blotted on to nylon filters and probed with sequence-specific oligonucleotide (SSO) probes. RESULTS--No DPA1 or DPB1 allele was significantly associated with SLE, or with any immunological or clinical subset of SLE. Evidence was found for only limited linkage disequilibrium between HLA-DP and HLA-DQ/DR variants, and none between HLA-DP and the TAP2 gene. CONCLUSIONS--These data indicate that HLA-DP genes do not contribute towards determining susceptibility to SLE.

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Selected References

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