Skip to main content
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1992 Feb;51(2):286–288. doi: 10.1136/ard.51.2.286

A brief overview of the pathogenesis of scleroderma (systemic sclerosis).

E C LeRoy 1
PMCID: PMC1005679  PMID: 1550420

Full text

PDF
288

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beck K., Hunter I., Engel J. Structure and function of laminin: anatomy of a multidomain glycoprotein. FASEB J. 1990 Feb 1;4(2):148–160. doi: 10.1096/fasebj.4.2.2404817. [DOI] [PubMed] [Google Scholar]
  2. Chiquet-Ehrismann R. What distinguishes tenascin from fibronectin? FASEB J. 1990 Jun;4(9):2598–2604. doi: 10.1096/fasebj.4.9.1693347. [DOI] [PubMed] [Google Scholar]
  3. Dang N. H., Torimoto Y., Schlossman S. F., Morimoto C. Human CD4 helper T cell activation: functional involvement of two distinct collagen receptors, 1F7 and VLA integrin family. J Exp Med. 1990 Aug 1;172(2):649–652. doi: 10.1084/jem.172.2.649. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hawrylko E., Spertus A., Mele C. A., Oster N., Frieri M. Increased interleukin-2 production in response to human type I collagen stimulation in patients with systemic sclerosis. Arthritis Rheum. 1991 May;34(5):580–587. doi: 10.1002/art.1780340510. [DOI] [PubMed] [Google Scholar]
  5. Hemler M. E. VLA proteins in the integrin family: structures, functions, and their role on leukocytes. Annu Rev Immunol. 1990;8:365–400. doi: 10.1146/annurev.iy.08.040190.002053. [DOI] [PubMed] [Google Scholar]
  6. Huffstutter J. E., DeLustro F. A., LeRoy E. C. Cellular immunity to collagen and laminin in scleroderma. Arthritis Rheum. 1985 Jul;28(7):775–780. doi: 10.1002/art.1780280708. [DOI] [PubMed] [Google Scholar]
  7. Ishikawa O., LeRoy E. C., Trojanowska M. Mitogenic effect of transforming growth factor beta 1 on human fibroblasts involves the induction of platelet-derived growth factor alpha receptors. J Cell Physiol. 1990 Oct;145(1):181–186. doi: 10.1002/jcp.1041450124. [DOI] [PubMed] [Google Scholar]
  8. Kahaleh M. B., LeRoy E. C. Interleukin-2 in scleroderma: correlation of serum level with extent of skin involvement and disease duration. Ann Intern Med. 1989 Mar 15;110(6):446–450. doi: 10.7326/0003-4819-110-6-446. [DOI] [PubMed] [Google Scholar]
  9. Kahaleh M. B., Leroy E. C. Endothelial injury in scleroderma. A protease mechanism. J Lab Clin Med. 1983 Apr;101(4):553–560. [PubMed] [Google Scholar]
  10. Kahaleh M. B., Osborn I., LeRoy E. C. Increased factor VIII/von Willebrand factor antigen and von Willebrand factor activity in scleroderma and in Raynaud's phenomenon. Ann Intern Med. 1981 Apr;94(4 Pt 1):482–484. doi: 10.7326/0003-4819-94-4-482. [DOI] [PubMed] [Google Scholar]
  11. Kahaleh M. B., Sherer G. K., LeRoy E. C. Endothelial injury in scleroderma. J Exp Med. 1979 Jun 1;149(6):1326–1335. doi: 10.1084/jem.149.6.1326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kahaleh M. B. Vascular disease in scleroderma. Endothelial T lymphocyte-fibroblast interactions. Rheum Dis Clin North Am. 1990 Feb;16(1):53–73. [PubMed] [Google Scholar]
  13. Kulozik M., Hogg A., Lankat-Buttgereit B., Krieg T. Co-localization of transforming growth factor beta 2 with alpha 1(I) procollagen mRNA in tissue sections of patients with systemic sclerosis. J Clin Invest. 1990 Sep;86(3):917–922. doi: 10.1172/JCI114793. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Leroy E. C. Connective tissue synthesis by scleroderma skin fibroblasts in cell culture. J Exp Med. 1972 Jun 1;135(6):1351–1362. doi: 10.1084/jem.135.6.1351. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Leroy E. C., Smith E. A., Kahaleh M. B., Trojanowska M., Silver R. M. A strategy for determining the pathogenesis of systemic sclerosis. Is transforming growth factor beta the answer? Arthritis Rheum. 1989 Jul;32(7):817–825. [PubMed] [Google Scholar]
  16. Matsuyama T., Yamada A., Kay J., Yamada K. M., Akiyama S. K., Schlossman S. F., Morimoto C. Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex. J Exp Med. 1989 Oct 1;170(4):1133–1148. doi: 10.1084/jem.170.4.1133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Maul G. G., Jimenez S. A., Riggs E., Ziemnicka-Kotula D. Determination of an epitope of the diffuse systemic sclerosis marker antigen DNA topoisomerase I: sequence similarity with retroviral p30gag protein suggests a possible cause for autoimmunity in systemic sclerosis. Proc Natl Acad Sci U S A. 1989 Nov;86(21):8492–8496. doi: 10.1073/pnas.86.21.8492. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Rüegg C. R., Chiquet-Ehrismann R., Alkan S. S. Tenascin, an extracellular matrix protein, exerts immunomodulatory activities. Proc Natl Acad Sci U S A. 1989 Oct;86(19):7437–7441. doi: 10.1073/pnas.86.19.7437. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Shimizu Y., Van Seventer G. A., Horgan K. J., Shaw S. Regulated expression and binding of three VLA (beta 1) integrin receptors on T cells. Nature. 1990 May 17;345(6272):250–253. doi: 10.1038/345250a0. [DOI] [PubMed] [Google Scholar]
  20. Shimizu Y., van Seventer G. A., Horgan K. J., Shaw S. Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin. J Immunol. 1990 Jul 1;145(1):59–67. [PubMed] [Google Scholar]
  21. Springer T. A. Adhesion receptors of the immune system. Nature. 1990 Aug 2;346(6283):425–434. doi: 10.1038/346425a0. [DOI] [PubMed] [Google Scholar]
  22. Tan E. M. Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv Immunol. 1989;44:93–151. doi: 10.1016/s0065-2776(08)60641-0. [DOI] [PubMed] [Google Scholar]
  23. Trojanowska M., Wu L. T., LeRoy E. C. Elevated expression of c-myc proto-oncogene in scleroderma fibroblasts. Oncogene. 1988 Oct;3(4):477–481. [PubMed] [Google Scholar]
  24. Wayner E. A., Garcia-Pardo A., Humphries M. J., McDonald J. A., Carter W. G. Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin. J Cell Biol. 1989 Sep;109(3):1321–1330. doi: 10.1083/jcb.109.3.1321. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES