Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1975 Aug;34(4):350–353. doi: 10.1136/ard.34.4.350

Eosinophil-specific and other granulocyte-specific antinuclear antibodies in juvenile chronic polyarthritis and adult rheumatoid arthritis.

J N Rosenberg, G D Johnson, E J Holborow, E G Bywaters
PMCID: PMC1006426  PMID: 1081376

Abstract

Sera from 151 children of whom 112 had juvenile chronic polyarthritis (JCP), and from adults with rheumatoid arthritis (RA), and from healthy pregnant females were tested for the presence of granulocyte-specific antinuclear antibodies (GS-ANA). These were detected in 20% of sera from cases of JCP, in 68% of adult RA, but in none of the controls. Eosinophil-specific ANA were the only ANA present in 18% of positive children and 54% of the positive adults. GS-ANA in children were predominantly IgG and of low titre. Heat-stable GS-ANA were detected in sera from eight children but none bound complement. The presence of GS-ANA was not significantly associated with sex, age of onset, duration of disease, mean active joint count, mean ESR, nor with the presence of fever, rash, splenomegaly, amyloidosis, pericarditis, or rheumatoid factor.

Full text

PDF
352

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALEXANDER W. R., BREMNER J. M., DUTHIE J. J. Incidence of the anti-nuclear factor in human sera. Ann Rheum Dis. 1960 Dec;19:338–350. doi: 10.1136/ard.19.4.338. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. ANSELL B. M., BYWATERS E. G. Prognosis in Still's disease. Bull Rheum Dis. 1959 May;9(9):189–192. [PubMed] [Google Scholar]
  3. BARNETT E. V., CONDEMI J. J., LEDDY J. P., VAUGHAN J. H. GAMMA-2, GAMMA-1A AND GAMMA-1M ANTINUCLEAR FACTORS IN HUMAN SERA. J Clin Invest. 1964 Jun;43:1104–1115. doi: 10.1172/JCI104995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bluestone R., Goldberg L. S., Katz R. M., Marchesano J. M., Calabro J. J. Juvenile rheumatoid arthritis--a serologic survey of 200 consecutive patients. J Pediatr. 1970 Jul;77(1):98–102. doi: 10.1016/s0022-3476(70)80050-6. [DOI] [PubMed] [Google Scholar]
  5. Elling P., Graudal H., Faber V. Granulocyte-specific antinuclear factors in serum and synovial fluid in rheumatoid arthritis. Ann Rheum Dis. 1968 May;27(3):225–233. doi: 10.1136/ard.27.3.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. FABER V., ELLING P., NORUP G., MANSA B., NISSEN N. I. AN ANTINUCLEAR FACTOR SPECIFIC FOR LEUCOCYTES. Lancet. 1964 Aug 15;2(7355):344–345. doi: 10.1016/s0140-6736(64)90283-1. [DOI] [PubMed] [Google Scholar]
  7. Faber V., Elling P. Leucocyte-specific anti-nuclear factors in patients with felty's syndrome, rheumatoid arthritis, systemic lupus erythematosus and other diseases. Acta Med Scand. 1966 Mar;179(3):257–267. doi: 10.1111/j.0954-6820.1966.tb05457.x. [DOI] [PubMed] [Google Scholar]
  8. Gibson D. C., Quarles J. M. Immunofluorescent detection of antinuclear factor using washed, pooled peripheral human leukocytes. Am J Clin Pathol. 1969 Apr;51(4):440–444. doi: 10.1093/ajcp/51.4.440. [DOI] [PubMed] [Google Scholar]
  9. Munthe E. Anti-IgG and antinuclear antibodies in juvenile rheumatoid arthritis. Scand J Rheumatol. 1972;1(4):161–170. doi: 10.3109/03009747209105006. [DOI] [PubMed] [Google Scholar]
  10. Nairn R. C. Standardization in immunofluorescence. Clin Exp Immunol. 1968 Jul;3(6):465–476. [PMC free article] [PubMed] [Google Scholar]
  11. O'Neill P., Johnson G. D. Multispot immunofluorescence: a simple semi-automatic method of processing large numbers of tests. J Clin Pathol. 1970 Mar;23(2):185–187. doi: 10.1136/jcp.23.2.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Schaller J. G., Johnson G. D., Holborow E. J., Ansell B. M., Smiley W. K. The association of antinuclear antibodies with the chronic iridocyclitis of juvenile rheumatoid arthritis (Still's disease). Arthritis Rheum. 1974 Jul-Aug;17(4):409–416. doi: 10.1002/art.1780170411. [DOI] [PubMed] [Google Scholar]
  13. WARD D. J., JOHNSON G. D., HOLBOROW E. J. ANTINUCLEAR FACTOR IN RHEUMATOID ARTHRITIS, ITS INCIDENCE AND CLINICAL SIGNIFICANCE. Ann Rheum Dis. 1964 Jul;23:306–310. doi: 10.1136/ard.23.4.306. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Wiik A., Munthe E. Restrictions among heavy and light chain determinants of granulocyte-specific antinuclear factors. Immunology. 1972 Jul;23(1):53–60. [PMC free article] [PubMed] [Google Scholar]
  15. Zvaifler N. J., Martinez M. M. Antinuclear factors and chronic articular inflammation. Clin Exp Immunol. 1971 Feb;8(2):271–278. [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES