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. 1976 Feb;35(1):14–22. doi: 10.1136/ard.35.1.14

Arthritis of mice induced by Mycoplasma arthritidis. Humoral antibody and lymphocyte responses of CBA mice.

B C Cole, L Golightly-Rowland, J R Ward
PMCID: PMC1006500  PMID: 1275576

Abstract

Peak arthritis occurred 7 days after intravenous injection of CBA mice with Mycoplasma arthritidis and persisted in some animals for 84 days. A marked leucocytosis was apparent for the first 21 days. Complement-fixing antibodies reached a peak 14 days after injection of the organisms and persisted at high levels for 84 days. Metabolic-inhibiting and mycoplasmacidal antibodies were present but at much lower titres.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersson J., Sjöberg O., Möller G. Induction of immunoglobulin and antibody synthesis in vitro by lipopolysaccharides. Eur J Immunol. 1972 Aug;2(4):349–353. doi: 10.1002/eji.1830020410. [DOI] [PubMed] [Google Scholar]
  2. Bergquist L. M., Lau B. H., Winter C. E. Mycoplasma-associated immunosuppression: effect on hemagglutinin response to common antigens in rabbits. Infect Immun. 1974 Feb;9(2):410–415. doi: 10.1128/iai.9.2.410-415.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Boyle W. An extension of the 51Cr-release assay for the estimation of mouse cytotoxins. Transplantation. 1968 Sep;6(6):761–764. doi: 10.1097/00007890-196809000-00002. [DOI] [PubMed] [Google Scholar]
  4. CHANOCK R. M., HAYFLICK L., BARILE M. F. Growth on artificial medium of an agent associated with atypical pneumonia and its identification as a PPLO. Proc Natl Acad Sci U S A. 1962 Jan 15;48:41–49. doi: 10.1073/pnas.48.1.41. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cahill J. F., Cole B. C., Wiley B. B., Ward J. R. Role of Biological Mimicry in the Pathogenesis of Rat Arthritis Induced by Mycoplasma arthritidis. Infect Immun. 1971 Jan;3(1):24–35. doi: 10.1128/iai.3.1.24-35.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Coke B. C., Ward J. R., Golightly-Rowland C., Trapp G. A. Chronic proliferative arthritis of mice induced by Mycoplasma arthritidis. II. Serological responses of the lost and effect of vaccines. Infect Immun. 1971 Oct;4(4):431–440. doi: 10.1128/iai.4.4.431-440.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cole B. C., Cahill J. F., Wiley B. B., Ward J. R. Immunological responses of the rat to Mycoplasma arthritidis. J Bacteriol. 1969 Jun;98(3):930–937. doi: 10.1128/jb.98.3.930-937.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Cole B. C., Golightly-Rowland L., Ward J. R. Chronic proliferative arthritis of mice induced by Mycoplasma arthritidis: demonstration of a cell-mediated immune response to mycoplasma antigens in vitro. Infect Immun. 1975 May;11(5):1159–1161. doi: 10.1128/iai.11.5.1159-1161.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Cole B. C., Ward J. R. Interaction of Mycoplasma arthritidis and other mycoplasmas with murine peritoneal macrophages. Infect Immun. 1973 May;7(5):691–699. doi: 10.1128/iai.7.5.691-699.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Cole B. C., Ward J. R., Jones R. S., Cahill J. F. Chronic proliferative arthritis of mice induced by Mycoplasma arthritidis. I. Induction of disease and histopathological characteristics. Infect Immun. 1971 Oct;4(4):344–355. doi: 10.1128/iai.4.4.344-355.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Colley D. G. Schistosomal egg antigen-induced lymphocyte blastogenesis in experimental murine Schistosoma mansoni infection. J Immunol. 1971 Nov;107(5):1477–1480. [PubMed] [Google Scholar]
  12. Copperman R., Morton H. E. Reversible inhibition of mitosis in lymphocyte cultures by non-viable Mycoplasma. Proc Soc Exp Biol Med. 1966 Dec;123(3):790–795. doi: 10.3181/00379727-123-31605. [DOI] [PubMed] [Google Scholar]
  13. Denny F. W., Taylor-Robinson D., Allison A. C. The role of thymus-dependent immunity in Mycoplasma pulmonis infections of mice. J Med Microbiol. 1972 Aug;5(3):327–336. doi: 10.1099/00222615-5-3-327. [DOI] [PubMed] [Google Scholar]
  14. Dutton R. W. Symposium on in vitro studies of the immune response. II. Significance of the reaction of lymphoid cells to homologous tissue. Bacteriol Rev. 1966 Jun;30(2):397–407. doi: 10.1128/br.30.2.397-407.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. FORD D. K. Rheumatoid arthritis--an infection? Arthritis Rheum. 1963 Apr;6:159–165. doi: 10.1002/art.1780060207. [DOI] [PubMed] [Google Scholar]
  16. Golightly-Rowland L., Cole B. C., Ward J. R., Wiley B. B. Effect of Animal Passage on Arthritogenic and Biological Properties of Mycoplasma arthritidis. Infect Immun. 1970 Jun;1(6):538–545. doi: 10.1128/iai.1.6.538-545.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Hayflick L. Tissue cultures and mycoplasmas. Tex Rep Biol Med. 1965 Jun;23(Suppl):285+–285+. [PubMed] [Google Scholar]
  18. Janossy G., Greaves M. F. Lymphocyte activation. I. Response of T and B lymphocytes to phytomitogens. Clin Exp Immunol. 1971 Oct;9(4):483–498. [PMC free article] [PubMed] [Google Scholar]
  19. Kaklamanis E., Pavlatos M. The immunosuppressive effect of mycoplasma infection. I. Effect on the humoral and cellular response. Immunology. 1972 Apr;22(4):695–702. [PMC free article] [PubMed] [Google Scholar]
  20. LAWRENCE H. S. Homograft sensitivity. An expression of the immunologic origins and consequences of individuality. Physiol Rev. 1959 Oct;39:811–859. doi: 10.1152/physrev.1959.39.4.811. [DOI] [PubMed] [Google Scholar]
  21. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  22. Oppenheim J. J. Relationship of in vitro lymphocyte transformation to delayed hypersensitivity in guinea pigs and man. Fed Proc. 1968 Jan-Feb;27(1):21–28. [PubMed] [Google Scholar]
  23. Purcell R. H., Taylor-Robinson D., Wong D. C., Chanock R. M. A color test for the measurement of antibody to the non-acid-forming human Mycoplasma species. Am J Epidemiol. 1966 Jul;84(1):51–66. doi: 10.1093/oxfordjournals.aje.a120627. [DOI] [PubMed] [Google Scholar]
  24. Simberkoff M. S., Thorbecke G. J., Thomas L. Studies of PPLO infection. V. Inhibition of lymphocyte mitosis and antibody formation by mycoplasmal extracts. J Exp Med. 1969 Jun 1;129(6):1163–1181. doi: 10.1084/jem.129.6.1163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Turk A., Glade P. R., Chessin L. N. Blast-like transformation induced in peripheral blood lymphocytes by cellular injury: a comparison of sonication and phytohemagglutinin. Blood. 1969 Feb;33(2):329–340. [PubMed] [Google Scholar]

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