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. 1977 Feb;36(1):39–43. doi: 10.1136/ard.36.1.39

Relationship of antibody affinity to onset of immune complex disease in New Zealand mice.

R E Petty, M W Steward
PMCID: PMC1006627  PMID: 139132

Abstract

Affinity (KR) of antibody to human serum transferrin in New Zealand mice was measured by a globulin precipitation technique. KR was low in mice immunized early in life, increased with age of immunization up to 16-26 weeks, and then fell to low levels. KR in young and old NZB mice was increased by immunization with antigen in Freund's complete adjuvant. The correlation between low affinity antibody production and susceptibility to immune complex disease is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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