Abstract
Several epidemiological studies of workers exposed to cadmium indicate an increased risk of lung and prostatic cancer. The increase is statistically significant in some of the studies but the SMR is greater than 100 in almost all. A cohort study of the mortality among 522 Swedish workers exposed to cadmium for at least one year in a nickel-cadmium battery plant support the earlier findings. The SMR for lung and prostatic cancer increased with increasing dose and latency but did not obtain statistical significance. A combination of all the available data from the most recent follow up of causes of death among cadmium workers in six different cohorts shows 28 cases of prostatic cancer (SMR = 162) and 195 cases of lung cancer (SMR = 121). This new analysis suggests that long term, high level exposure to cadmium is associated with an increased risk of cancer. The role of concomitant exposure to nickel needs further study.
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- Hernberg S. Evaluation of epidemiologic studies in assessing the long-term effects of occupational noxious agents. Scand J Work Environ Health. 1980 Sep;6(3):163–169. doi: 10.5271/sjweh.2620. [DOI] [PubMed] [Google Scholar]
- Hogstedt C., Andersson K., Frenning B., Gustavsson A. A cohort study on mortality among long-time employed Swedish chimney sweeps. Scand J Work Environ Health. 1982;8 (Suppl 1):72–78. [PubMed] [Google Scholar]
- Kazantzis G., Armstrong B. G. Renal function in relation to low levels of cadmium exposure in a group of smelter workers. Environ Health Perspect. 1984 Mar;54:193–199. doi: 10.1289/ehp.8454193. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kjellström T., Evrin P. E., Rahnster B. Dose-response analysis of cadmium-induced tubular proteinuria: a study of urinary beta2-microglobulin excretion among workers in a battery factory. Environ Res. 1977 Apr;13(2):303–317. doi: 10.1016/0013-9351(77)90106-2. [DOI] [PubMed] [Google Scholar]
- Kjellström T., Friberg L., Rahnster B. Mortality and cancer morbidity among cadmium-exposed workers. Environ Health Perspect. 1979 Feb;28:199–204. doi: 10.1289/ehp.28-1637490. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lemen R. A., Lee J. S., Wagoner J. K., Blejer H. P. Cancer mortality among cadmium production workers. Ann N Y Acad Sci. 1976;271:273–279. doi: 10.1111/j.1749-6632.1976.tb23122.x. [DOI] [PubMed] [Google Scholar]
- POTTS C. L. CADMIUM PROTEINURIA--THE HEALTH OF BATTERY WORKERS EXPOSED TO CADMIUM OXIDE DUST. Ann Occup Hyg. 1965 Mar;8:55–61. doi: 10.1093/annhyg/8.1.55. [DOI] [PubMed] [Google Scholar]
- Sorahan T., Waterhouse J. A. Mortality study of nickel-cadmium battery workers by the method of regression models in life tables. Br J Ind Med. 1983 Aug;40(3):293–300. doi: 10.1136/oem.40.3.293. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Soter N. A., Wasserman S. I., Austen K. F. Cold urticaria: release into the circulation of histamine and eosinophil chemotactic factor of anaphylaxis during cold challenge. N Engl J Med. 1976 Mar 25;294(13):687–690. doi: 10.1056/NEJM197603252941302. [DOI] [PubMed] [Google Scholar]
- Sunderman F. W., Jr Recent advances in metal carcinogenesis. Ann Clin Lab Sci. 1984 Mar-Apr;14(2):93–122. [PubMed] [Google Scholar]
- Takenaka S., Oldiges H., König H., Hochrainer D., Oberdörster G. Carcinogenicity of cadmium chloride aerosols in W rats. J Natl Cancer Inst. 1983 Feb;70(2):367–373. [PubMed] [Google Scholar]
- Thun M. J., Schnorr T. M., Smith A. B., Halperin W. E., Lemen R. A. Mortality among a cohort of U.S. cadmium production workers--an update. J Natl Cancer Inst. 1985 Feb;74(2):325–333. [PubMed] [Google Scholar]