Abstract
Occupational toluene exposure was studied during the workshift and the morning after by the analysis of environmental air, alveolar air, and blood. Environmental toluene exposure was measured by both continuous and instantaneous sampling. Instantaneous environmental toluene concentrations correlated better with alveolar toluene concentrations (r = 0.94; n = 155) than with blood toluene concentrations (r = 0.71; n = 52). Continuous environmental toluene concentrations correlated better with blood toluene concentrations (r = 0.84; n = 65) than with alveolar toluene concentrations (r = 0.52; n = 46). During the workshift and the morning after, blood and alveolar toluene concentrations correlated significantly with each other (r = 0.75; n = 66 and r = 0.67; n = 52). In a group of workers who were exposed to a mean environmental toluene concentration of 146 micromilligrams the concentrations of toluene in the alveolar air and blood the morning after were 3.2 micromilligrams (SD = 1.7) and 27.5 micromilligrams (SD = 12.7) respectively. With regard to the morning after toluene determinations, blood concentrations correlated (r = 0.52; n = 52; p less than 0.001) better than the alveolar concentrations with the corresponding afternoon values (r = 0.36; n = 52; p less than 0.01). The decline of the toluene concentrations from the end of one workshift to the start of the next exposure indicated a mean toluene half life of 3.8 hours in the alveolar air and of 4.5 hours in blood and therefore the 17 hour interval between two consecutive workshifts was insufficient for the complete elimination of absorbed toluene.
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- Angerer J., Behling K. Chronische Lösungsmittelbelastung am Arbeitsplatz. IX. Ein Verfahren zur Evaluierung von Grenzwerten für Parameter der inneren Belastung am Beispiel der Toluolexposition. Int Arch Occup Environ Health. 1981;48(2):137–146. doi: 10.1007/BF00378434. [DOI] [PubMed] [Google Scholar]
- Apostoli P., Brugnone F., Perbellini L., Cocheo V., Bellomo M. L., Silvestri R. Biomonitoring of occupational toluene exposure. Int Arch Occup Environ Health. 1982;50(2):153–168. doi: 10.1007/BF00378077. [DOI] [PubMed] [Google Scholar]
- Brugnone F., Perbellini L., Apostoli P., Locatelli M., Mariotto P. Decline of blood and alveolar toluene concentration following two accidental human poisonings. Int Arch Occup Environ Health. 1983;53(2):157–165. doi: 10.1007/BF00378428. [DOI] [PubMed] [Google Scholar]
- Carlsson A., Ljungquist E. Exposure to toluene: concentration in subcutaneous adipose tissue. Scand J Work Environ Health. 1982 Mar;8(1):56–62. doi: 10.5271/sjweh.2496. [DOI] [PubMed] [Google Scholar]
- Cohr K. H., Stokholm J. Toluene. A toxicologic review. Scand J Work Environ Health. 1979 Jun;5(2):71–90. doi: 10.5271/sjweh.2664. [DOI] [PubMed] [Google Scholar]
- Ovrum P., Hultengren M., Lindqvist T. Exposure to toluene in a photogravure printing plant. Concentration in ambient air and uptake in the body. Scand J Work Environ Health. 1978 Sep;4(3):237–245. doi: 10.5271/sjweh.2702. [DOI] [PubMed] [Google Scholar]
- Szadkowski D., Pett R., Angerer J., Manz A., Lehnert G. Chronische Lösungsmittelbelastung am Arbeitsplatz. II. Schadstoffspiegel im Blut und Metabolitenelimination im Harn in ihrer Bedeutung als Uberwachungskriterien bei toluolexponierten Tiefdruckern. Int Arch Arbeitsmed. 1973;31(4):265–276. [PubMed] [Google Scholar]
- Veulemans H., Masschelein R. Experimental human exposure to toluene. I. Factors influencing the individual respiratory uptake and elimination. Int Arch Occup Environ Health. 1978 Nov 15;42(2):91–103. doi: 10.1007/BF01297548. [DOI] [PubMed] [Google Scholar]
- Veulemans H., Masschelein R. Experimental human exposure to toluene. II. Toluene in venous blood during and after exposure. Int Arch Occup Environ Health. 1978 Nov 15;42(2):105–117. doi: 10.1007/BF01297549. [DOI] [PubMed] [Google Scholar]