Abstract
A group of 92 farmers had clinical evaluation, pulmonary function tests, and bronchoalveolar lavage (BAL). There were 12 patients with acute farmers' lung disease (FLD) (group 1) and 37 farmers who had had acute FLD, of whom 22 were still on their farm (group 2) and 15 had ceased contact (group 3); others were normal dairy farmers, 23 serology positive to Micropolyspora faeni (group 4), 20 serology negative (group 5), and 42 normal controls (group 6). Of the 134 subjects, 59 had an increase in alveolar lymphocytes (greater than 22% lymphocytes in BAL) (12 in group 1, 19 in group 2, six in group 3, 14 in group 4, five in group 5, and three in group 6). Within each group there was no correlation between BAL lymphocytes (% and absolute number) and most pulmonary function tests. It is concluded that although an increase in BAL lymphocytes is always seen in acute FLD it may also be seen in the absence of clinically evident disease and that BAL lymphocytosis does not correlate with physiological changes in FLD.
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Selected References
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- Chmelik F., DoPico G., Reed C. E., Dickie H. Farmer's lung. J Allergy Clin Immunol. 1974 Sep;54(3):180–188. doi: 10.1016/0091-6749(74)90055-4. [DOI] [PubMed] [Google Scholar]
- Cormier Y., Bélanger J., Durand P. Factors influencing the development of serum precipitins to farmer's lung antigen in Quebec dairy farmers. Thorax. 1985 Feb;40(2):138–142. doi: 10.1136/thx.40.2.138. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hunninghake G. W., Gadek J. E., Kawanami O., Ferrans V. J., Crystal R. G. Inflammatory and immune processes in the human lung in health and disease: evaluation by bronchoalveolar lavage. Am J Pathol. 1979 Oct;97(1):149–206. [PMC free article] [PubMed] [Google Scholar]
- Keogh B. A., Crystal R. G. Alveolitis: the key to the interstitial lung disorders. Thorax. 1982 Jan;37(1):1–10. doi: 10.1136/thx.37.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reynolds H. Y., Fulmer J. D., Kazmierowski J. A., Roberts W. C., Frank M. M., Crystal R. G. Analysis of cellular and protein content of broncho-alveolar lavage fluid from patients with idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis. J Clin Invest. 1977 Jan;59(1):165–175. doi: 10.1172/JCI108615. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Salvaggio J. E., Karr R. M. Hypersensitivity pneumonitis; state of the art. Chest. 1979 Feb;75(2 Suppl):270–274. [PubMed] [Google Scholar]
- Solal-Céligny P., Laviolette M., Hébert J., Cormier Y. Immune reactions in the lungs of asymptomatic dairy farmers. Am Rev Respir Dis. 1982 Dec;126(6):964–967. doi: 10.1164/arrd.1982.126.6.964. [DOI] [PubMed] [Google Scholar]
- Valenti S., Scordamaglia A., Crimi P., Mereu C. Bronchoalveolar lavage and transbronchial lung biopsy in sarcoidosis and extrinsic allergic alveolitis. Eur J Respir Dis. 1982 Nov;63(6):564–569. [PubMed] [Google Scholar]
- Voisin C., Tonnel A. B., Aerts C., Lafitte J. J., Ramon P. H. Les populations cellulaires des espaces aériens broncho-alvéolaires dans la sarcoïdose, les alvéolites allergiques extrinsèques et les cancers bronchiques. Nouv Presse Med. 1977 Sep 17;6(30):2685–2685. [PubMed] [Google Scholar]
- Voisin C., Tonnel A. B., Lahoute C., Robin H., Lebas J., Aerts C. Bird fancier's lung: studies of broncho-alveolar lavage and correlations with inhalation provocation tests. Lung. 1981;159(1):17–22. doi: 10.1007/BF02713892. [DOI] [PubMed] [Google Scholar]