Abstract
The data presented in this paper show statistically significant dose response relations between cumulative exposure to benzene (ppm-months) and mortality from both all lymphopoietic cancer combined and leukaemia. Chemical workers with a cumulative exposure to benzene of at least 720 ppm-months experienced a relative risk of 3.93 for lymphatic and haematopoietic cancer when compared with workers with no occupational exposure. The dose response relation between cumulative exposure and non-Hodgkin's lymphopoietic cancer was of borderline statistical significance (p = 0.06). No dose response relation was detected for any other causes of death.
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- Aksoy M. Benzene and leukemia. Lancet. 1978 Feb 25;1(8061):441–441. doi: 10.1016/s0140-6736(78)91226-6. [DOI] [PubMed] [Google Scholar]
- Decouflé P., Blattner W. A., Blair A. Mortality among chemical workers exposed to benzene and other agents. Environ Res. 1983 Feb;30(1):16–25. doi: 10.1016/0013-9351(83)90161-5. [DOI] [PubMed] [Google Scholar]
- Esmen N. Retrospective industrial hygiene surveys. Am Ind Hyg Assoc J. 1979 Jan;40(1):58–65. doi: 10.1080/15298667991429327. [DOI] [PubMed] [Google Scholar]
- Linos A., Kyle R. A., O'Fallon W. M., Kurland L. T. A case-control study of occupational exposures and leukaemia. Int J Epidemiol. 1980 Jun;9(2):131–135. doi: 10.1093/ije/9.2.131. [DOI] [PubMed] [Google Scholar]
- MANTEL N., HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4):719–748. [PubMed] [Google Scholar]
- Ott M. G., Townsend J. C., Fishbeck W. A., Langner R. A. Mortality among individuals occupationally exposed to benzene. Arch Environ Health. 1978 Jan-Feb;33(1):3–10. doi: 10.1080/00039896.1978.10667299. [DOI] [PubMed] [Google Scholar]
- Rinsky R. A., Young R. J., Smith A. B. Leukemia in benzene workers. Am J Ind Med. 1981;2(3):217–245. doi: 10.1002/ajim.4700020305. [DOI] [PubMed] [Google Scholar]
- Wong O. An industry wide mortality study of chemical workers occupationally exposed to benzene. I. General results. Br J Ind Med. 1987 Jun;44(6):365–381. doi: 10.1136/oem.44.6.365. [DOI] [PMC free article] [PubMed] [Google Scholar]