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. 1978 Feb;35(1):8–15. doi: 10.1136/oem.35.1.8

Arsenic exposure and mortality: a case-referent study from a Swedish copper smelter.

O Axelson, E Dahlgren, C D Jansson, S O Rehnlund
PMCID: PMC1008317  PMID: 629894

Abstract

An increased mortality from lung cancer, cardiovascular disease, haematolymphatic malignancy and cirrhosis of the liver has been reported among smelter workers and others exposed to arsenic. This study uses the case-referent (case-control) technique and is concerned with workers in a copper smelter in a complex work environment, characterised by the presence of trivalent arsenic in combination with sulphur dioxide and copper, and also with other agents. Lung cancer mortality was found to be increased about five-fold and cardiovascular disease about two-fold, showing a dose-response relationship to arsenic exposure. Mortality from malignant blood disease (leukaemia and myeloma) and cirrhosis of the liver was also slightly increased. This mortality pattern among the smelter workers is consistent with earlier reports. An increased mortality from cardiovascular disease in this type of industry is of particular interest as it has been reported only once before.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BIRMINGHAM D. J., KEY M. M., HOLADAY D. A., PERONE V. B. AN OUTBREAK OF ARSENICAL DERMATOSES IN A MINING COMMUNITY. Arch Dermatol. 1965 May;91:457–464. doi: 10.1001/archderm.1965.01600110043010. [DOI] [PubMed] [Google Scholar]
  2. DINGWALL-FORDYCE I., LANE R. E. A FOLLOW-UP STUDY OF LEAD WORKERS. Br J Ind Med. 1963 Oct;20:313–315. doi: 10.1136/oem.20.4.313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Glazener F. S., Ellis J. G., Johnson P. K. Electrocardiographic findings with arsenic poisoning. Calif Med. 1968 Aug;109(2):158–162. [PMC free article] [PubMed] [Google Scholar]
  4. HOLMQVIST I. Occupational arsenical dermatitis; a study among employees at a copper ore smelting work including investigations of skin reactions to contact with arsenic compounds. Acta Derm Venereol Suppl (Stockh) 1951;26:1–214. [PubMed] [Google Scholar]
  5. Kuratsune M., Tokudome S., Shirakusa T., Yoshida M., Tokumitsu Y. Occupational lung cancer among copper smelters. Int J Cancer. 1974 Apr 15;13(4):552–558. doi: 10.1002/ijc.2910130415. [DOI] [PubMed] [Google Scholar]
  6. Lee A. M., Fraumeni J. F., Jr Arsenic and respiratory cancer in man: an occupational study. J Natl Cancer Inst. 1969 Jun;42(6):1045–1052. [PubMed] [Google Scholar]
  7. MANTEL N., HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4):719–748. [PubMed] [Google Scholar]
  8. McMichael A. J., Spirtas R., Kupper L. L., Gamble J. F. Solvent exposure and leukemia among rubber workers: an epidemiologic study. J Occup Med. 1975 Apr;17(4):234–239. [PubMed] [Google Scholar]
  9. Miettinen O. S. Components of the crude risk ratio. Am J Epidemiol. 1972 Aug;96(2):168–172. doi: 10.1093/oxfordjournals.aje.a121443. [DOI] [PubMed] [Google Scholar]
  10. Miettinen O. S. Matching and design efficiency in retrospective studies. Am J Epidemiol. 1970 Feb;91(2):111–118. doi: 10.1093/oxfordjournals.aje.a121118. [DOI] [PubMed] [Google Scholar]
  11. Miettinen O. S. Standardization of risk ratios. Am J Epidemiol. 1972 Dec;96(6):383–388. doi: 10.1093/oxfordjournals.aje.a121470. [DOI] [PubMed] [Google Scholar]
  12. Miettinen O. Estimability and estimation in case-referent studies. Am J Epidemiol. 1976 Feb;103(2):226–235. doi: 10.1093/oxfordjournals.aje.a112220. [DOI] [PubMed] [Google Scholar]
  13. Ott M. G., Holder B. B., Gordon H. L. Respiratory cancer and occupational exposure to arsenicals. Arch Environ Health. 1974 Nov;29(5):250–255. doi: 10.1080/00039896.1974.10666582. [DOI] [PubMed] [Google Scholar]
  14. PINTO S. S., BENNETT B. M. EFFECT OF ARSENIC TRIOXIDE EXPOSURE ON MORTALITY. Arch Environ Health. 1963 Nov;7:583–591. doi: 10.1080/00039896.1963.10663587. [DOI] [PubMed] [Google Scholar]
  15. PINTO S. S., MCGILL C. M. Arsenic trioxide exposure in industry. Ind Med Surg. 1953 Jul;22(7):281–287. [PubMed] [Google Scholar]
  16. de Faire U., Friberg L., Lorich U., Lundman T. A validation of cause-of-death certification in 1,156 deaths. Acta Med Scand. 1976;200(3):223–228. doi: 10.1111/j.0954-6820.1976.tb08223.x. [DOI] [PubMed] [Google Scholar]

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