Abstract
An acute inhalation chamber study of 42 college students was performed to investigate the relation between exposure to 0, 75, and 150 ppm of toluene and changes in central nervous system function and symptoms. Paid subjects were exposed for seven hours over three days. Verbal and visual short term memory (Sternberg, digit span, Benton, pattern memory); perception (pattern recognition); psychomotor skill (simple reaction time, continuous performance, digit symbol, hand-eye coordination, finger tapping, and critical tracking); manual dexterity (one hole); mood (profile of mood scales (POMS]; fatigue (fatigue checklist); and verbal ability were evaluated at 0800, 1200, and 1600 hours. Voluntary symptoms and observations of sleep were collected daily. An analysis of variance and test for trend was performed on the difference and score for each concentration reflecting an eight hour workday where each subject was their own control. A 3 x 3 Latin square study design evaluated toluene effects simultaneously, controlling for learning across the three days and the solvent order. Intersubject variation in solvent uptake was monitored in breath and urine. A 5-10% decrement in performance was considered significant if it was consistent with a linear trend at p less than 0.05. Adverse performance at 150 ppm toluene was found at 6.0% for digit span, 12.1% for pattern recognition (latency), 5.0% for pattern memory (number correct), 6.5% for one hole, and 3.0% for critical tracking. The number of headaches and eye irritation also increased in a dose response manner. The greatest effect was found for an increasing number of observations of sleep. Overall, no clear pattern of neurobehavioural effects was found consistent with the type 1 central nervous system as classified by the World Health Organisation. Subtle acute effects, however, were found just below and above the ACGIH TLV of 100 ppm toluene, supporting the position that the guideline be lowered since the biological threshold of behavioural effects may be comparable with the TLV.
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- Baker E. L., Fine L. J. Solvent neurotoxicity: the current evidence. J Occup Med. 1986 Feb;28(2):126–129. [PubMed] [Google Scholar]
- Baker E. L., Letz R. E., Fidler A. T., Shalat S., Plantamura D., Lyndon M. A computer-based neurobehavioral evaluation system for occupational and environmental epidemiology: methodology and validation studies. Neurobehav Toxicol Teratol. 1985 Jul-Aug;7(4):369–377. [PubMed] [Google Scholar]
- Baker E. L., Letz R., Fidler A. A computer-administered neurobehavioral evaluation system for occupational and environmental epidemiology. Rationale, methodology, and pilot study results. J Occup Med. 1985 Mar;27(3):206–212. [PubMed] [Google Scholar]
- Carlsson A. Exposure to toluene: uptake, distribution and elimination in man. Scand J Work Environ Health. 1982 Mar;8(1):43–55. doi: 10.5271/sjweh.2497. [DOI] [PubMed] [Google Scholar]
- Cherry N., Venables H., Waldron H. A. The acute behavioural effects of solvent exposure. J Soc Occup Med. 1983 Jan;33(1):13–18. doi: 10.1093/occmed/33.1.13. [DOI] [PubMed] [Google Scholar]
- Dick R. B., Setzer J. V., Wait R., Hayden M. B., Taylor B. J., Tolos B., Putz-Anderson V. Effects of acute exposure of toluene and methyl ethyl ketone on psychomotor performance. Int Arch Occup Environ Health. 1984;54(2):91–109. doi: 10.1007/BF00378512. [DOI] [PubMed] [Google Scholar]
- Fidler A. T., Baker E. L., Letz R. E. Neurobehavioural effects of occupational exposure to organic solvents among construction painters. Br J Ind Med. 1987 May;44(5):292–308. doi: 10.1136/oem.44.5.292. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Iregren A., Akerstedt T., Anshelm Olson B., Gamberale F. Experimental exposure to toluene in combination with ethanol intake. Psychophysiological functions. Scand J Work Environ Health. 1986 Apr;12(2):128–136. doi: 10.5271/sjweh.2167. [DOI] [PubMed] [Google Scholar]
- Iregren A. Effects on psychological test performance of workers exposed to a single solvent (toluene)--a comparison with effects of exposure to a mixture of organic solvents. Neurobehav Toxicol Teratol. 1982 Nov-Dec;4(6):695–701. [PubMed] [Google Scholar]
- Maizlish N. A., Fine L. J., Albers J. W., Whitehead L., Langolf G. D. A neurological evaluation of workers exposed to mixtures of organic solvents. Br J Ind Med. 1987 Jan;44(1):14–25. doi: 10.1136/oem.44.1.14. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nomiyama K., Nomiyama H. Respiratory retention, uptake and excretion of organic solvents in man. Int Arch Arbeitsmed. 1974;32(1):75–83. doi: 10.1007/BF00539097. [DOI] [PubMed] [Google Scholar]
- Ogata M., Tomokuni K., Takatsuka Y. Urinary excretion of hippuric acid and m- or p-methylhippuric acid in the urine of persons exposed to vapours of toluene and m- or p-xylene as a test of exposure. Br J Ind Med. 1970 Jan;27(1):43–50. doi: 10.1136/oem.27.1.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Olson B. A., Gamberale F., Iregren A. Coexposure to toluene and p-xylene in man: central nervous functions. Br J Ind Med. 1985 Feb;42(2):117–122. doi: 10.1136/oem.42.2.117. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Salmi A., Ziola B., Reunanen M., Julkunen I., Wager O. Immune complexes in serum and cerebrospinal fluid of multiple sclerosis patients and patients with other neurological diseases. Acta Neurol Scand. 1982 Jul;66(1):1–15. doi: 10.1111/j.1600-0404.1982.tb03124.x. [DOI] [PubMed] [Google Scholar]
- Smith P. J., Langolf G. D., Goldberg J. Effect of occupational exposure to elemental mercury on short term memory. Br J Ind Med. 1983 Nov;40(4):413–419. doi: 10.1136/oem.40.4.413. [DOI] [PMC free article] [PubMed] [Google Scholar]