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. 1989 Dec;46(12):856–859. doi: 10.1136/oem.46.12.856

Manganese induced parkinsonism: an outbreak due to an unrepaired ventilation control system in a ferromanganese smelter.

J D Wang 1, C C Huang 1, Y H Hwang 1, J R Chiang 1, J M Lin 1, J S Chen 1
PMCID: PMC1009882  PMID: 2611159

Abstract

Several cases of parkinsonism were found in a ferromanganese smelter after the ventilation system had broken down and had not been repaired for eight months in 1985. To determine the aetiology and prevalence of parkinsonism, 132 workers were submitted to thorough medical examination and estimated air concentrations of carbon monoxide and manganese at different worksites. Only six of eight workers performing electrode fixation or welding during 1985 developed parkinsonism. They were exposed for 30 minutes each day, seven days a week, to high concentrations of air manganese (greater than 28.8 mg/m3). There was a consistent trend between the index of exposure to manganese and signs and symptoms exhibited by extrapyramidal systems. After repair of the ventilation system, the air concentration of manganese during electrode fixation and welding decreased to less than 4.4 mg/m3; furthermore, no new cases of parkinsonism have been observed. Workers with parkinsonism recovered partially after removal from original worksites and treatment with levodopa. It is concluded that the outbreak resulted from exposure to high concentrations of manganese fumes through the breakdown of the ventilation system.

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Selected References

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  1. GILBERT G. J., GLASER G. H. Neurologic manifestations of chronic carbon monoxide poisoning. N Engl J Med. 1959 Dec 10;261:1217–1220. doi: 10.1056/NEJM195912102612404. [DOI] [PubMed] [Google Scholar]
  2. Hassanein M., Ghaleb H. A., Haroun E. A., Hegazy M. R., Khayyal M. A. Chronic manganism: preliminary observations on glucose tolerance and serum proteins. Br J Ind Med. 1966 Jan;23(1):67–70. doi: 10.1136/oem.23.1.67. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Mena I., Horiuchi K., Burke K., Cotzias G. C. Chronic manganese poisoning. Individual susceptibility and absorption of iron. Neurology. 1969 Oct;19(10):1000–1006. doi: 10.1212/wnl.19.10.1000. [DOI] [PubMed] [Google Scholar]
  4. RODIER J. Manganese poisoning in Moroccan miners. Br J Ind Med. 1955 Jan;12(1):21–35. doi: 10.1136/oem.12.1.21. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ringel S. P., Klawans H. L., Jr Carbon monoxide-induced Parkinsonism. J Neurol Sci. 1972 Jul;16(3):245–251. doi: 10.1016/0022-510x(72)90190-6. [DOI] [PubMed] [Google Scholar]
  6. Roels H., Lauwerys R., Genet P., Sarhan M. J., de Fays M., Hanotiau I., Buchet J. P. Relationship between external and internal parameters of exposure to manganese in workers from a manganese oxide and salt producing plant. Am J Ind Med. 1987;11(3):297–305. doi: 10.1002/ajim.4700110307. [DOI] [PubMed] [Google Scholar]
  7. SCHULER P., OYANGUREN H., MATURANA V., VALENZUELA A., CRUZ E., PLAZA V., SCHMIDT E., HADDAD R. Manganese poisoning; environmental and medical study at a Chilean mine. Ind Med Surg. 1957 Apr;26(4):167–173. [PubMed] [Google Scholar]
  8. Sarić M., Markićević A., Hrustić O. Occupational exposure to manganese. Br J Ind Med. 1977 May;34(2):114–118. [PMC free article] [PubMed] [Google Scholar]
  9. Smyth L. T., Ruhf R. C., Whitman N. E., Dugan T. Clinical manganism and exposure to manganese in the production and processing of ferromanganese alloy. J Occup Med. 1973 Feb;15(2):101–109. [PubMed] [Google Scholar]
  10. Stewart R. D. The effect of carbon monoxide on humans. Annu Rev Pharmacol. 1975;15:409–423. doi: 10.1146/annurev.pa.15.040175.002205. [DOI] [PubMed] [Google Scholar]
  11. Tanaka S., Lieben J. Manganese poisoning and exposure in Pennsylvania. Arch Environ Health. 1969 Nov;19(5):674–684. doi: 10.1080/00039896.1969.10666909. [DOI] [PubMed] [Google Scholar]
  12. Tsalev D. L., Langmyhr F. J., Gunderson N. Direct atomic absorption spectrometric determination of manganese in whole blood of unexposed individuals and exposed workers in a Norwegian manganese alloy plant. Bull Environ Contam Toxicol. 1977 Jun;17(6):660–666. doi: 10.1007/BF01685949. [DOI] [PubMed] [Google Scholar]
  13. Ulrich C. E., Rinehart W., Brandt M. Evaluation of the chronic inhalation toxicity of a manganese oxide aerosol. III. Pulmonary function, electromyograms, limb tremor, and tissue manganese data. Am Ind Hyg Assoc J. 1979 May;40(5):349–353. doi: 10.1080/15298667991429688. [DOI] [PubMed] [Google Scholar]
  14. Whitlock C. M., Jr, Amuso S. J., Bittenbender J. B. Chronic neurological disease in two manganese steel workers. Am Ind Hyg Assoc J. 1966 Sep-Oct;27(5):454–459. doi: 10.1080/00028896609342453. [DOI] [PubMed] [Google Scholar]

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