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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1996 Jan;55(1):7–20. doi: 10.1136/ard.55.1.7

Nitric oxide.

A J Farrell 1, D R Blake 1
PMCID: PMC1010074  PMID: 8572740

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Selected References

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  1. Albina J. E., Abate J. A., Henry W. L., Jr Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role of IFN-gamma in the induction of the nitric oxide-synthesizing pathway. J Immunol. 1991 Jul 1;147(1):144–148. [PubMed] [Google Scholar]
  2. Albina J. E., Cui S., Mateo R. B., Reichner J. S. Nitric oxide-mediated apoptosis in murine peritoneal macrophages. J Immunol. 1993 Jun 1;150(11):5080–5085. [PubMed] [Google Scholar]
  3. Allescher H. D., Tougas G., Vergara P., Lu S., Daniel E. E. Nitric oxide as a putative nonadrenergic noncholinergic inhibitory transmitter in the canine pylorus in vivo. Am J Physiol. 1992 Apr;262(4 Pt 1):G695–G702. doi: 10.1152/ajpgi.1992.262.4.G695. [DOI] [PubMed] [Google Scholar]
  4. Amezcua J. L., Palmer R. M., de Souza B. M., Moncada S. Nitric oxide synthesized from L-arginine regulates vascular tone in the coronary circulation of the rabbit. Br J Pharmacol. 1989 Aug;97(4):1119–1124. doi: 10.1111/j.1476-5381.1989.tb12569.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Archer S. L., Tolins J. P., Raij L., Weir E. K. Hypoxic pulmonary vasoconstriction is enhanced by inhibition of the synthesis of an endothelium derived relaxing factor. Biochem Biophys Res Commun. 1989 Nov 15;164(3):1198–1205. doi: 10.1016/0006-291x(89)91796-8. [DOI] [PubMed] [Google Scholar]
  6. Axelsson K. L., Andersson R. G. Tolerance towards nitroglycerin, induced in vivo, is correlated to a reduced cGMP response and an alteration in cGMP turnover. Eur J Pharmacol. 1983 Mar 18;88(1):71–79. doi: 10.1016/0014-2999(83)90393-x. [DOI] [PubMed] [Google Scholar]
  7. Barbul A., Lazarou S. A., Efron D. T., Wasserkrug H. L., Efron G. Arginine enhances wound healing and lymphocyte immune responses in humans. Surgery. 1990 Aug;108(2):331–337. [PubMed] [Google Scholar]
  8. Baylis C., Mitruka B., Deng A. Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage. J Clin Invest. 1992 Jul;90(1):278–281. doi: 10.1172/JCI115849. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Beasley D., Schwartz J. H., Brenner B. M. Interleukin 1 induces prolonged L-arginine-dependent cyclic guanosine monophosphate and nitrite production in rat vascular smooth muscle cells. J Clin Invest. 1991 Feb;87(2):602–608. doi: 10.1172/JCI115036. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Beckerman K. P., Rogers H. W., Corbett J. A., Schreiber R. D., McDaniel M. L., Unanue E. R. Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes. J Immunol. 1993 Feb 1;150(3):888–895. [PubMed] [Google Scholar]
  11. Beckman J. S., Beckman T. W., Chen J., Marshall P. A., Freeman B. A. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1620–1624. doi: 10.1073/pnas.87.4.1620. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Belvisi M. G., Stretton D., Barnes P. J. Nitric oxide as an endogenous modulator of cholinergic neurotransmission in guinea-pig airways. Eur J Pharmacol. 1991 Jun 6;198(2-3):219–221. doi: 10.1016/0014-2999(91)90626-2. [DOI] [PubMed] [Google Scholar]
  13. Blake D. R., Merry P., Unsworth J., Kidd B. L., Outhwaite J. M., Ballard R., Morris C. J., Gray L., Lunec J. Hypoxic-reperfusion injury in the inflamed human joint. Lancet. 1989 Feb 11;1(8633):289–293. doi: 10.1016/s0140-6736(89)91305-6. [DOI] [PubMed] [Google Scholar]
  14. Boeckxstaens G. E., Pelckmans P. A., Bult H., De Man J. G., Herman A. G., Van Maercke Y. M. Non-adrenergic non-cholinergic relaxation mediated by nitric oxide in the canine ileocolonic junction. Eur J Pharmacol. 1990 Nov 6;190(1-2):239–246. doi: 10.1016/0014-2999(90)94132-h. [DOI] [PubMed] [Google Scholar]
  15. Bogdan C., Vodovotz Y., Paik J., Xie Q. W., Nathan C. Traces of bacterial lipopolysaccharide suppress IFN-gamma-induced nitric oxide synthase gene expression in primary mouse macrophages. J Immunol. 1993 Jul 1;151(1):301–309. [PubMed] [Google Scholar]
  16. Boje K. M., Arora P. K. Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res. 1992 Aug 7;587(2):250–256. doi: 10.1016/0006-8993(92)91004-x. [DOI] [PubMed] [Google Scholar]
  17. Boughton-Smith N. K., Evans S. M., Hawkey C. J., Cole A. T., Balsitis M., Whittle B. J., Moncada S. Nitric oxide synthase activity in ulcerative colitis and Crohn's disease. Lancet. 1993 Aug 7;342(8867):338–340. doi: 10.1016/0140-6736(93)91476-3. [DOI] [PubMed] [Google Scholar]
  18. Braughler J. M. Soluble guanylate cyclase activation by nitric oxide and its reversal. Involvement of sulfhydryl group oxidation and reduction. Biochem Pharmacol. 1983 Mar 1;32(5):811–818. doi: 10.1016/0006-2952(83)90581-6. [DOI] [PubMed] [Google Scholar]
  19. Bredt D. S., Ferris C. D., Snyder S. H. Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites. J Biol Chem. 1992 Jun 5;267(16):10976–10981. [PubMed] [Google Scholar]
  20. Bredt D. S., Hwang P. M., Glatt C. E., Lowenstein C., Reed R. R., Snyder S. H. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature. 1991 Jun 27;351(6329):714–718. doi: 10.1038/351714a0. [DOI] [PubMed] [Google Scholar]
  21. Bredt D. S., Hwang P. M., Snyder S. H. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature. 1990 Oct 25;347(6295):768–770. doi: 10.1038/347768a0. [DOI] [PubMed] [Google Scholar]
  22. Bredt D. S., Snyder S. H. Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci U S A. 1989 Nov;86(22):9030–9033. doi: 10.1073/pnas.86.22.9030. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Bryant J. L., Jr, Mehta P., Von der Porten A., Mehta J. L. Co-purification of 130 kD nitric oxide synthase and a 22 kD link protein from human neutrophils. Biochem Biophys Res Commun. 1992 Nov 30;189(1):558–564. doi: 10.1016/0006-291x(92)91594-g. [DOI] [PubMed] [Google Scholar]
  24. Buisson A., Plotkine M., Boulu R. G. The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia. Br J Pharmacol. 1992 Aug;106(4):766–767. doi: 10.1111/j.1476-5381.1992.tb14410.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Burkart V., Imai Y., Kallmann B., Kolb H. Cyclosporin A protects pancreatic islet cells from nitric oxide-dependent macrophage cytotoxicity. FEBS Lett. 1992 Nov 16;313(1):56–58. doi: 10.1016/0014-5793(92)81183-m. [DOI] [PubMed] [Google Scholar]
  26. Burnett A. L., Lowenstein C. J., Bredt D. S., Chang T. S., Snyder S. H. Nitric oxide: a physiologic mediator of penile erection. Science. 1992 Jul 17;257(5068):401–403. doi: 10.1126/science.1378650. [DOI] [PubMed] [Google Scholar]
  27. Calandra T., Baumgartner J. D., Grau G. E., Wu M. M., Lambert P. H., Schellekens J., Verhoef J., Glauser M. P. Prognostic values of tumor necrosis factor/cachectin, interleukin-1, interferon-alpha, and interferon-gamma in the serum of patients with septic shock. Swiss-Dutch J5 Immunoglobulin Study Group. J Infect Dis. 1990 May;161(5):982–987. doi: 10.1093/infdis/161.5.982. [DOI] [PubMed] [Google Scholar]
  28. Calver A., Collier J., Moncada S., Vallance P. Effect of local intra-arterial NG-monomethyl-L-arginine in patients with hypertension: the nitric oxide dilator mechanism appears abnormal. J Hypertens. 1992 Sep;10(9):1025–1031. [PubMed] [Google Scholar]
  29. Carreras M. C., Pargament G. A., Catz S. D., Poderoso J. J., Boveris A. Kinetics of nitric oxide and hydrogen peroxide production and formation of peroxynitrite during the respiratory burst of human neutrophils. FEBS Lett. 1994 Mar 14;341(1):65–68. doi: 10.1016/0014-5793(94)80241-6. [DOI] [PubMed] [Google Scholar]
  30. Chapman P. F., Atkins C. M., Allen M. T., Haley J. E., Steinmetz J. E. Inhibition of nitric oxide synthesis impairs two different forms of learning. Neuroreport. 1992 Jul;3(7):567–570. doi: 10.1097/00001756-199207000-00005. [DOI] [PubMed] [Google Scholar]
  31. Chartrain N. A., Geller D. A., Koty P. P., Sitrin N. F., Nussler A. K., Hoffman E. P., Billiar T. R., Hutchinson N. I., Mudgett J. S. Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene. J Biol Chem. 1994 Mar 4;269(9):6765–6772. [PubMed] [Google Scholar]
  32. Chen P. Y., Sanders P. W. L-arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats. J Clin Invest. 1991 Nov;88(5):1559–1567. doi: 10.1172/JCI115467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Chester A. H., O'Neil G. S., Moncada S., Tadjkarimi S., Yacoub M. H. Low basal and stimulated release of nitric oxide in atherosclerotic epicardial coronary arteries. Lancet. 1990 Oct 13;336(8720):897–900. doi: 10.1016/0140-6736(90)92269-n. [DOI] [PubMed] [Google Scholar]
  34. Cho H. J., Xie Q. W., Calaycay J., Mumford R. A., Swiderek K. M., Lee T. D., Nathan C. Calmodulin is a subunit of nitric oxide synthase from macrophages. J Exp Med. 1992 Aug 1;176(2):599–604. doi: 10.1084/jem.176.2.599. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Chu A., Chambers D. E., Lin C. C., Kuehl W. D., Palmer R. M., Moncada S., Cobb F. R. Effects of inhibition of nitric oxide formation on basal vasomotion and endothelium-dependent responses of the coronary arteries in awake dogs. J Clin Invest. 1991 Jun;87(6):1964–1968. doi: 10.1172/JCI115223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Clancy R. M., Leszczynska-Piziak J., Abramson S. B. Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase. J Clin Invest. 1992 Sep;90(3):1116–1121. doi: 10.1172/JCI115929. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Clark I. A., Rockett K. A., Cowden W. B. Possible central role of nitric oxide in conditions clinically similar to cerebral malaria. Lancet. 1992 Oct 10;340(8824):894–896. doi: 10.1016/0140-6736(92)93295-x. [DOI] [PubMed] [Google Scholar]
  38. Corbett J. A., Sweetland M. A., Wang J. L., Lancaster J. R., Jr, McDaniel M. L. Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1731–1735. doi: 10.1073/pnas.90.5.1731. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Corbett J. A., Tilton R. G., Chang K., Hasan K. S., Ido Y., Wang J. L., Sweetland M. A., Lancaster J. R., Jr, Williamson J. R., McDaniel M. L. Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction. Diabetes. 1992 Apr;41(4):552–556. doi: 10.2337/diab.41.4.552. [DOI] [PubMed] [Google Scholar]
  40. Cui S., Reichner J. S., Mateo R. B., Albina J. E. Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or -independent mechanisms. Cancer Res. 1994 May 1;54(9):2462–2467. [PubMed] [Google Scholar]
  41. Cunha F. Q., Moncada S., Liew F. Y. Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-gamma in murine macrophages. Biochem Biophys Res Commun. 1992 Feb 14;182(3):1155–1159. doi: 10.1016/0006-291x(92)91852-h. [DOI] [PubMed] [Google Scholar]
  42. Curran R. D., Billiar T. R., Stuehr D. J., Hofmann K., Simmons R. L. Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells. J Exp Med. 1989 Nov 1;170(5):1769–1774. doi: 10.1084/jem.170.5.1769. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Damoulis P. D., Hauschka P. V. Cytokines induce nitric oxide production in mouse osteoblasts. Biochem Biophys Res Commun. 1994 Jun 15;201(2):924–931. doi: 10.1006/bbrc.1994.1790. [DOI] [PubMed] [Google Scholar]
  44. Dananberg J., Sider R. S., Grekin R. J. Sustained hypertension induced by orally administered nitro-L-arginine. Hypertension. 1993 Mar;21(3):359–363. doi: 10.1161/01.hyp.21.3.359. [DOI] [PubMed] [Google Scholar]
  45. Dawson T. M., Bredt D. S., Fotuhi M., Hwang P. M., Snyder S. H. Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7797–7801. doi: 10.1073/pnas.88.17.7797. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Dawson V. L., Dawson T. M., London E. D., Bredt D. S., Snyder S. H. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6368–6371. doi: 10.1073/pnas.88.14.6368. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Dimmeler S., Lottspeich F., Brüne B. Nitric oxide causes ADP-ribosylation and inhibition of glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem. 1992 Aug 25;267(24):16771–16774. [PubMed] [Google Scholar]
  48. Dinh Xuan A. T., Higenbottam T. W., Clelland C., Pepke-Zaba J., Cremona G., Wallwork J. Impairment of pulmonary endothelium-dependent relaxation in patients with Eisenmenger's syndrome. Br J Pharmacol. 1990 Jan;99(1):9–10. doi: 10.1111/j.1476-5381.1990.tb14643.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Dinh Xuan A. T., Higenbottam T. W., Pepke-Zaba J., Clelland C., Wallwork J. Reduced endothelium-dependent relaxation of cystic fibrosis pulmonary arteries. Eur J Pharmacol. 1989 Apr 25;163(2-3):401–403. doi: 10.1016/0014-2999(89)90217-3. [DOI] [PubMed] [Google Scholar]
  50. Dinh-Xuan A. T., Higenbottam T. W., Clelland C. A., Pepke-Zaba J., Cremona G., Butt A. Y., Large S. R., Wells F. C., Wallwork J. Impairment of endothelium-dependent pulmonary-artery relaxation in chronic obstructive lung disease. N Engl J Med. 1991 May 30;324(22):1539–1547. doi: 10.1056/NEJM199105303242203. [DOI] [PubMed] [Google Scholar]
  51. Dirnagl U., Lindauer U., Villringer A. Role of nitric oxide in the coupling of cerebral blood flow to neuronal activation in rats. Neurosci Lett. 1993 Jan 4;149(1):43–46. doi: 10.1016/0304-3940(93)90343-j. [DOI] [PubMed] [Google Scholar]
  52. Drapier J. C., Hibbs J. B., Jr Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells. J Immunol. 1988 Apr 15;140(8):2829–2838. [PubMed] [Google Scholar]
  53. Drapier J. C., Hirling H., Wietzerbin J., Kaldy P., Kühn L. C. Biosynthesis of nitric oxide activates iron regulatory factor in macrophages. EMBO J. 1993 Sep;12(9):3643–3649. doi: 10.1002/j.1460-2075.1993.tb06038.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Drexler H., Zeiher A. M., Meinzer K., Just H. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine. Lancet. 1991 Dec 21;338(8782-8783):1546–1550. doi: 10.1016/0140-6736(91)92372-9. [DOI] [PubMed] [Google Scholar]
  55. Efron D. T., Kirk S. J., Regan M. C., Wasserkrug H. L., Barbul A. Nitric oxide generation from L-arginine is required for optimal human peripheral blood lymphocyte DNA synthesis. Surgery. 1991 Aug;110(2):327–334. [PubMed] [Google Scholar]
  56. Ekelund U., Mellander S. Role of endothelium-derived nitric oxide in the regulation of tonus in large-bore arterial resistance vessels, arterioles and veins in cat skeletal muscle. Acta Physiol Scand. 1990 Nov;140(3):301–309. doi: 10.1111/j.1748-1716.1990.tb09004.x. [DOI] [PubMed] [Google Scholar]
  57. Faraci F. M., Breese K. R. Nitric oxide mediates vasodilatation in response to activation of N-methyl-D-aspartate receptors in brain. Circ Res. 1993 Feb;72(2):476–480. doi: 10.1161/01.res.72.2.476. [DOI] [PubMed] [Google Scholar]
  58. Farrell A. J., Blake D. R., Palmer R. M., Moncada S. Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Ann Rheum Dis. 1992 Nov;51(11):1219–1222. doi: 10.1136/ard.51.11.1219. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Farrell A. J., Williams R. B., Stevens C. R., Lawrie A. S., Cox N. L., Blake D. R. Exercise induced release of von Willebrand factor: evidence for hypoxic reperfusion microvascular injury in rheumatoid arthritis. Ann Rheum Dis. 1992 Oct;51(10):1117–1122. doi: 10.1136/ard.51.10.1117. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Fast D. J., Shannon B. J., Herriott M. J., Kennedy M. J., Rummage J. A., Leu R. W. Staphylococcal exotoxins stimulate nitric oxide-dependent murine macrophage tumoricidal activity. Infect Immun. 1991 Sep;59(9):2987–2993. doi: 10.1128/iai.59.9.2987-2993.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. Fehsel K., Jalowy A., Qi S., Burkart V., Hartmann B., Kolb H. Islet cell DNA is a target of inflammatory attack by nitric oxide. Diabetes. 1993 Mar;42(3):496–500. doi: 10.2337/diab.42.3.496. [DOI] [PubMed] [Google Scholar]
  62. Ferrante R. J., Kowall N. W., Beal M. F., Richardson E. P., Jr, Bird E. D., Martin J. B. Selective sparing of a class of striatal neurons in Huntington's disease. Science. 1985 Nov 1;230(4725):561–563. doi: 10.1126/science.2931802. [DOI] [PubMed] [Google Scholar]
  63. Gally J. A., Montague P. R., Reeke G. N., Jr, Edelman G. M. The NO hypothesis: possible effects of a short-lived, rapidly diffusible signal in the development and function of the nervous system. Proc Natl Acad Sci U S A. 1990 May;87(9):3547–3551. doi: 10.1073/pnas.87.9.3547. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Garg U. C., Hassid A. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest. 1989 May;83(5):1774–1777. doi: 10.1172/JCI114081. [DOI] [PMC free article] [PubMed] [Google Scholar]
  65. Garside P., Hutton A. K., Severn A., Liew F. Y., Mowat A. M. Nitric oxide mediates intestinal pathology in graft-vs.-host disease. Eur J Immunol. 1992 Aug;22(8):2141–2145. doi: 10.1002/eji.1830220827. [DOI] [PubMed] [Google Scholar]
  66. Garthwaite J., Garthwaite G. Cellular origins of cyclic GMP responses to excitatory amino acid receptor agonists in rat cerebellum in vitro. J Neurochem. 1987 Jan;48(1):29–39. doi: 10.1111/j.1471-4159.1987.tb13123.x. [DOI] [PubMed] [Google Scholar]
  67. Gillespie J. S., Liu X. R., Martin W. The effects of L-arginine and NG-monomethyl L-arginine on the response of the rat anococcygeus muscle to NANC nerve stimulation. Br J Pharmacol. 1989 Dec;98(4):1080–1082. doi: 10.1111/j.1476-5381.1989.tb12650.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  68. Girerd X. J., Hirsch A. T., Cooke J. P., Dzau V. J., Creager M. A. L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits. Circ Res. 1990 Dec;67(6):1301–1308. doi: 10.1161/01.res.67.6.1301. [DOI] [PubMed] [Google Scholar]
  69. Granger D. N., Benoit J. N., Suzuki M., Grisham M. B. Leukocyte adherence to venular endothelium during ischemia-reperfusion. Am J Physiol. 1989 Nov;257(5 Pt 1):G683–G688. doi: 10.1152/ajpgi.1989.257.5.G683. [DOI] [PubMed] [Google Scholar]
  70. Gryglewski R. J., Palmer R. M., Moncada S. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature. 1986 Apr 3;320(6061):454–456. doi: 10.1038/320454a0. [DOI] [PubMed] [Google Scholar]
  71. Hevel J. M., White K. A., Marletta M. A. Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein. J Biol Chem. 1991 Dec 5;266(34):22789–22791. [PubMed] [Google Scholar]
  72. Hibbs J. B., Jr, Taintor R. R., Vavrin Z. Iron depletion: possible cause of tumor cell cytotoxicity induced by activated macrophages. Biochem Biophys Res Commun. 1984 Sep 17;123(2):716–723. doi: 10.1016/0006-291x(84)90288-2. [DOI] [PubMed] [Google Scholar]
  73. Hibbs J. B., Jr, Westenfelder C., Taintor R., Vavrin Z., Kablitz C., Baranowski R. L., Ward J. H., Menlove R. L., McMurry M. P., Kushner J. P. Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy. J Clin Invest. 1992 Mar;89(3):867–877. doi: 10.1172/JCI115666. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Hoffman R. A., Langrehr J. M., Billiar T. R., Curran R. D., Simmons R. L. Alloantigen-induced activation of rat splenocytes is regulated by the oxidative metabolism of L-arginine. J Immunol. 1990 Oct 1;145(7):2220–2226. [PubMed] [Google Scholar]
  75. Hogaboam C. M., Befus A. D., Wallace J. L. Modulation of rat mast cell reactivity by IL-1 beta. Divergent effects on nitric oxide and platelet-activating factor release. J Immunol. 1993 Oct 1;151(7):3767–3774. [PubMed] [Google Scholar]
  76. Holt P. G., Oliver J., Bilyk N., McMenamin C., McMenamin P. G., Kraal G., Thepen T. Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages. J Exp Med. 1993 Feb 1;177(2):397–407. doi: 10.1084/jem.177.2.397. [DOI] [PMC free article] [PubMed] [Google Scholar]
  77. Hope B. T., Michael G. J., Knigge K. M., Vincent S. R. Neuronal NADPH diaphorase is a nitric oxide synthase. Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2811–2814. doi: 10.1073/pnas.88.7.2811. [DOI] [PMC free article] [PubMed] [Google Scholar]
  78. Huang P. L., Dawson T. M., Bredt D. S., Snyder S. H., Fishman M. C. Targeted disruption of the neuronal nitric oxide synthase gene. Cell. 1993 Dec 31;75(7):1273–1286. doi: 10.1016/0092-8674(93)90615-w. [DOI] [PubMed] [Google Scholar]
  79. Hughes S. R., Williams T. J., Brain S. D. Evidence that endogenous nitric oxide modulates oedema formation induced by substance P. Eur J Pharmacol. 1990 Dec 4;191(3):481–484. doi: 10.1016/0014-2999(90)94184-y. [DOI] [PubMed] [Google Scholar]
  80. Ialenti A., Ianaro A., Moncada S., Di Rosa M. Modulation of acute inflammation by endogenous nitric oxide. Eur J Pharmacol. 1992 Feb 11;211(2):177–182. doi: 10.1016/0014-2999(92)90526-a. [DOI] [PubMed] [Google Scholar]
  81. Ignarro L. J., Bush P. A., Buga G. M., Wood K. S., Fukuto J. M., Rajfer J. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem Biophys Res Commun. 1990 Jul 31;170(2):843–850. doi: 10.1016/0006-291x(90)92168-y. [DOI] [PubMed] [Google Scholar]
  82. Izumi Y., Clifford D. B., Zorumski C. F. Inhibition of long-term potentiation by NMDA-mediated nitric oxide release. Science. 1992 Aug 28;257(5074):1273–1276. doi: 10.1126/science.1519065. [DOI] [PubMed] [Google Scholar]
  83. Jacobs M., Plane F., Bruckdorfer K. R. Native and oxidized low-density lipoproteins have different inhibitory effects on endothelium-derived relaxing factor in the rabbit aorta. Br J Pharmacol. 1990 May;100(1):21–26. doi: 10.1111/j.1476-5381.1990.tb12045.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  84. Jain B., Rubinstein I., Robbins R. A., Leise K. L., Sisson J. H. Modulation of airway epithelial cell ciliary beat frequency by nitric oxide. Biochem Biophys Res Commun. 1993 Feb 26;191(1):83–88. doi: 10.1006/bbrc.1993.1187. [DOI] [PubMed] [Google Scholar]
  85. James S. L., Glaven J. Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates. J Immunol. 1989 Dec 15;143(12):4208–4212. [PubMed] [Google Scholar]
  86. Janssens S. P., Shimouchi A., Quertermous T., Bloch D. B., Bloch K. D. Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. J Biol Chem. 1992 Jul 25;267(21):14519–14522. [PubMed] [Google Scholar]
  87. Kaplan S. S., Billiar T., Curran R. D., Zdziarski U. E., Simmons R. L., Basford R. E. Inhibition of chemotaxis Ng-monomethyl-L-arginine: a role for cyclic GMP. Blood. 1989 Nov 1;74(6):1885–1887. [PubMed] [Google Scholar]
  88. Karupiah G., Xie Q. W., Buller R. M., Nathan C., Duarte C., MacMicking J. D. Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase. Science. 1993 Sep 10;261(5127):1445–1448. doi: 10.1126/science.7690156. [DOI] [PubMed] [Google Scholar]
  89. Kawabata A., Fukuzumi Y., Fukushima Y., Takagi H. Antinociceptive effect of L-arginine on the carrageenin-induced hyperalgesia of the rat: possible involvement of central opioidergic systems. Eur J Pharmacol. 1992 Jul 21;218(1):153–158. doi: 10.1016/0014-2999(92)90159-2. [DOI] [PubMed] [Google Scholar]
  90. Kawabata A., Nishimura Y., Takagi H. L-leucyl-L-arginine, naltrindole and D-arginine block antinociception elicited by L-arginine in mice with carrageenin-induced hyperalgesia. Br J Pharmacol. 1992 Dec;107(4):1096–1101. doi: 10.1111/j.1476-5381.1992.tb13413.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  91. Keaney J. F., Jr, Simon D. I., Stamler J. S., Jaraki O., Scharfstein J., Vita J. A., Loscalzo J. NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties. J Clin Invest. 1993 Apr;91(4):1582–1589. doi: 10.1172/JCI116364. [DOI] [PMC free article] [PubMed] [Google Scholar]
  92. Kelm M., Schrader J. Control of coronary vascular tone by nitric oxide. Circ Res. 1990 Jun;66(6):1561–1575. doi: 10.1161/01.res.66.6.1561. [DOI] [PubMed] [Google Scholar]
  93. Khalil Z., Helme R. D. The quantitative contribution of nitric oxide and sensory nerves to bradykinin-induced inflammation in rat skin microvasculature. Brain Res. 1992 Aug 28;589(1):102–108. doi: 10.1016/0006-8993(92)91167-d. [DOI] [PubMed] [Google Scholar]
  94. Kilbourn R. G., Belloni P. Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin. J Natl Cancer Inst. 1990 May 2;82(9):772–776. doi: 10.1093/jnci/82.9.772. [DOI] [PubMed] [Google Scholar]
  95. Kilbourn R. G., Jubran A., Gross S. S., Griffith O. W., Levi R., Adams J., Lodato R. F. Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis. Biochem Biophys Res Commun. 1990 Nov 15;172(3):1132–1138. doi: 10.1016/0006-291x(90)91565-a. [DOI] [PubMed] [Google Scholar]
  96. Kinsella J. P., Neish S. R., Shaffer E., Abman S. H. Low-dose inhalation nitric oxide in persistent pulmonary hypertension of the newborn. Lancet. 1992 Oct 3;340(8823):819–820. doi: 10.1016/0140-6736(92)92687-b. [DOI] [PubMed] [Google Scholar]
  97. Kirk S. J., Regan M. C., Barbul A. Cloned murine T lymphocytes synthesize a molecule with the biological characteristics of nitric oxide. Biochem Biophys Res Commun. 1990 Dec 14;173(2):660–665. doi: 10.1016/s0006-291x(05)80086-5. [DOI] [PubMed] [Google Scholar]
  98. Kishimoto J., Spurr N., Liao M., Lizhi L., Emson P., Xu W. Localization of brain nitric oxide synthase (NOS) to human chromosome 12. Genomics. 1992 Nov;14(3):802–804. doi: 10.1016/s0888-7543(05)80192-2. [DOI] [PubMed] [Google Scholar]
  99. Knowles R. G., Palacios M., Palmer R. M., Moncada S. Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase. Proc Natl Acad Sci U S A. 1989 Jul;86(13):5159–5162. doi: 10.1073/pnas.86.13.5159. [DOI] [PMC free article] [PubMed] [Google Scholar]
  100. Koh J. Y., Choi D. W. Vulnerability of cultured cortical neurons to damage by excitotoxins: differential susceptibility of neurons containing NADPH-diaphorase. J Neurosci. 1988 Jun;8(6):2153–2163. doi: 10.1523/JNEUROSCI.08-06-02153.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  101. Kolb H., Kiesel U., Kröncke K. D., Kolb-Bachofen V. Suppression of low dose streptozotocin induced diabetes in mice by administration of a nitric oxide synthase inhibitor. Life Sci. 1991;49(25):PL213–PL217. doi: 10.1016/0024-3205(91)90296-n. [DOI] [PubMed] [Google Scholar]
  102. Kolesnikov Y. A., Pick C. G., Pasternak G. W. NG-nitro-L-arginine prevents morphine tolerance. Eur J Pharmacol. 1992 Oct 20;221(2-3):399–400. doi: 10.1016/0014-2999(92)90732-j. [DOI] [PubMed] [Google Scholar]
  103. Kollegger H., McBean G. J., Tipton K. F. Reduction of striatal N-methyl-D-aspartate toxicity by inhibition of nitric oxide synthase. Biochem Pharmacol. 1993 Jan 7;45(1):260–264. doi: 10.1016/0006-2952(93)90401-h. [DOI] [PubMed] [Google Scholar]
  104. Kröncke K. D., Kolb-Bachofen V., Berschick B., Burkart V., Kolb H. Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation. Biochem Biophys Res Commun. 1991 Mar 29;175(3):752–758. doi: 10.1016/0006-291x(91)91630-u. [DOI] [PubMed] [Google Scholar]
  105. Kubes P., Kanwar S., Niu X. F., Gaboury J. P. Nitric oxide synthesis inhibition induces leukocyte adhesion via superoxide and mast cells. FASEB J. 1993 Oct;7(13):1293–1299. doi: 10.1096/fasebj.7.13.8405815. [DOI] [PubMed] [Google Scholar]
  106. Kubes P., Suzuki M., Granger D. N. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4651–4655. doi: 10.1073/pnas.88.11.4651. [DOI] [PMC free article] [PubMed] [Google Scholar]
  107. Kuo H. P., Liu S., Barnes P. J. The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways. Eur J Pharmacol. 1992 Oct 20;221(2-3):385–388. doi: 10.1016/0014-2999(92)90728-m. [DOI] [PubMed] [Google Scholar]
  108. Kurose I., Kubes P., Wolf R., Anderson D. C., Paulson J., Miyasaka M., Granger D. N. Inhibition of nitric oxide production. Mechanisms of vascular albumin leakage. Circ Res. 1993 Jul;73(1):164–171. doi: 10.1161/01.res.73.1.164. [DOI] [PubMed] [Google Scholar]
  109. Lahera V., Salom M. G., Miranda-Guardiola F., Moncada S., Romero J. C. Effects of NG-nitro-L-arginine methyl ester on renal function and blood pressure. Am J Physiol. 1991 Dec;261(6 Pt 2):F1033–F1037. doi: 10.1152/ajprenal.1991.261.6.F1033. [DOI] [PubMed] [Google Scholar]
  110. Lamas S., Marsden P. A., Li G. K., Tempst P., Michel T. Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6348–6352. doi: 10.1073/pnas.89.14.6348. [DOI] [PMC free article] [PubMed] [Google Scholar]
  111. Lancaster J. R., Jr, Langrehr J. M., Bergonia H. A., Murase N., Simmons R. L., Hoffman R. A. EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft. J Biol Chem. 1992 Jun 5;267(16):10994–10998. [PubMed] [Google Scholar]
  112. Lander H. M., Sehajpal P., Levine D. M., Novogrodsky A. Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds. J Immunol. 1993 Feb 15;150(4):1509–1516. [PubMed] [Google Scholar]
  113. Langrehr J. M., Dull K. E., Ochoa J. B., Billiar T. R., Ildstad S. T., Schraut W. H., Simmons R. L., Hoffman R. A. Evidence that nitric oxide production by in vivo allosensitized cells inhibits the development of allospecific CTL. Transplantation. 1992 Mar;53(3):632–640. doi: 10.1097/00007890-199203000-00027. [DOI] [PubMed] [Google Scholar]
  114. Langrehr J. M., Hoffman R. A., Billiar T. R., Lee K. K., Schraut W. H., Simmons R. L. Nitric oxide synthesis in the in vivo allograft response: a possible regulatory mechanism. Surgery. 1991 Aug;110(2):335–342. [PubMed] [Google Scholar]
  115. Langrehr J. M., Murase N., Markus P. M., Cai X., Neuhaus P., Schraut W., Simmons R. L., Hoffman R. A. Nitric oxide production in host-versus-graft and graft-versus-host reactions in the rat. J Clin Invest. 1992 Aug;90(2):679–683. doi: 10.1172/JCI115911. [DOI] [PMC free article] [PubMed] [Google Scholar]
  116. Langrehr J. M., Müller A. R., Bergonia H. A., Jacob T. D., Lee T. K., Schraut W. H., Lancaster J. R., Jr, Hoffman R. A., Simmons R. L. Detection of nitric oxide by electron paramagnetic resonance spectroscopy during rejection and graft-versus-host disease after small-bowel transplantation in the rat. Surgery. 1992 Aug;112(2):395–402. [PubMed] [Google Scholar]
  117. Laval F., Wink D. A. Inhibition by nitric oxide of the repair protein, O6-methylguanine-DNA-methyltransferase. Carcinogenesis. 1994 Mar;15(3):443–447. doi: 10.1093/carcin/15.3.443. [DOI] [PubMed] [Google Scholar]
  118. Lei S. Z., Pan Z. H., Aggarwal S. K., Chen H. S., Hartman J., Sucher N. J., Lipton S. A. Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex. Neuron. 1992 Jun;8(6):1087–1099. doi: 10.1016/0896-6273(92)90130-6. [DOI] [PubMed] [Google Scholar]
  119. Lepoivre M., Flaman J. M., Henry Y. Early loss of the tyrosyl radical in ribonucleotide reductase of adenocarcinoma cells producing nitric oxide. J Biol Chem. 1992 Nov 15;267(32):22994–23000. [PubMed] [Google Scholar]
  120. Leurs R., Brozius M. M., Jansen W., Bast A., Timmerman H. Histamine H1-receptor-mediated cyclic GMP production in guinea-pig lung tissue is an L-arginine-dependent process. Biochem Pharmacol. 1991 Jul 5;42(2):271–277. doi: 10.1016/0006-2952(91)90713-f. [DOI] [PubMed] [Google Scholar]
  121. Li C. G., Rand M. J. Evidence for a role of nitric oxide in the neurotransmitter system mediating relaxation of the rat anococcygeus muscle. Clin Exp Pharmacol Physiol. 1989 Dec;16(12):933–938. doi: 10.1111/j.1440-1681.1989.tb02404.x. [DOI] [PubMed] [Google Scholar]
  122. Liew F. Y., Millott S., Parkinson C., Palmer R. M., Moncada S. Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine. J Immunol. 1990 Jun 15;144(12):4794–4797. [PubMed] [Google Scholar]
  123. Lipton S. A., Choi Y. B., Pan Z. H., Lei S. Z., Chen H. S., Sucher N. J., Loscalzo J., Singel D. J., Stamler J. S. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature. 1993 Aug 12;364(6438):626–632. doi: 10.1038/364626a0. [DOI] [PubMed] [Google Scholar]
  124. Liu S. F., Crawley D. E., Barnes P. J., Evans T. W. Endothelium-derived relaxing factor inhibits hypoxic pulmonary vasoconstriction in rats. Am Rev Respir Dis. 1991 Jan;143(1):32–37. doi: 10.1164/ajrccm/143.1.32. [DOI] [PubMed] [Google Scholar]
  125. Lorsbach R. B., Murphy W. J., Lowenstein C. J., Snyder S. H., Russell S. W. Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide. J Biol Chem. 1993 Jan 25;268(3):1908–1913. [PubMed] [Google Scholar]
  126. Lorsbach R. B., Russell S. W. A specific sequence of stimulation is required to induce synthesis of the antimicrobial molecule nitric oxide by mouse macrophages. Infect Immun. 1992 May;60(5):2133–2135. doi: 10.1128/iai.60.5.2133-2135.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  127. Lyons C. R., Orloff G. J., Cunningham J. M. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J Biol Chem. 1992 Mar 25;267(9):6370–6374. [PubMed] [Google Scholar]
  128. Löwik C. W., Nibbering P. H., van de Ruit M., Papapoulos S. E. Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption. J Clin Invest. 1994 Apr;93(4):1465–1472. doi: 10.1172/JCI117124. [DOI] [PMC free article] [PubMed] [Google Scholar]
  129. Ma X. L., Weyrich A. S., Lefer D. J., Lefer A. M. Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium. Circ Res. 1993 Feb;72(2):403–412. doi: 10.1161/01.res.72.2.403. [DOI] [PubMed] [Google Scholar]
  130. MacIntyre I., Zaidi M., Alam A. S., Datta H. K., Moonga B. S., Lidbury P. S., Hecker M., Vane J. R. Osteoclastic inhibition: an action of nitric oxide not mediated by cyclic GMP. Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2936–2940. doi: 10.1073/pnas.88.7.2936. [DOI] [PMC free article] [PubMed] [Google Scholar]
  131. MacNaughton W. K., Cirino G., Wallace J. L. Endothelium-derived relaxing factor (nitric oxide) has protective actions in the stomach. Life Sci. 1989;45(20):1869–1876. doi: 10.1016/0024-3205(89)90540-7. [DOI] [PubMed] [Google Scholar]
  132. Malawista S. E., Montgomery R. R., van Blaricom G. Evidence for reactive nitrogen intermediates in killing of staphylococci by human neutrophil cytoplasts. A new microbicidal pathway for polymorphonuclear leukocytes. J Clin Invest. 1992 Aug;90(2):631–636. doi: 10.1172/JCI115903. [DOI] [PMC free article] [PubMed] [Google Scholar]
  133. Mandrup-Poulsen T., Helqvist S., Wogensen L. D., Mølvig J., Pociot F., Johannesen J., Nerup J. Cytokine and free radicals as effector molecules in the destruction of pancreatic beta cells. Curr Top Microbiol Immunol. 1990;164:169–193. doi: 10.1007/978-3-642-75741-9_9. [DOI] [PubMed] [Google Scholar]
  134. Marsden P. A., Ballermann B. J. Tumor necrosis factor alpha activates soluble guanylate cyclase in bovine glomerular mesangial cells via an L-arginine-dependent mechanism. J Exp Med. 1990 Dec 1;172(6):1843–1852. doi: 10.1084/jem.172.6.1843. [DOI] [PMC free article] [PubMed] [Google Scholar]
  135. Marsden P. A., Heng H. H., Duff C. L., Shi X. M., Tsui L. C., Hall A. V. Localization of the human gene for inducible nitric oxide synthase (NOS2) to chromosome 17q11.2-q12. Genomics. 1994 Jan 1;19(1):183–185. doi: 10.1006/geno.1994.1039. [DOI] [PubMed] [Google Scholar]
  136. Marsden P. A., Heng H. H., Scherer S. W., Stewart R. J., Hall A. V., Shi X. M., Tsui L. C., Schappert K. T. Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J Biol Chem. 1993 Aug 15;268(23):17478–17488. [PubMed] [Google Scholar]
  137. Marsden P. A., Schappert K. T., Chen H. S., Flowers M., Sundell C. L., Wilcox J. N., Lamas S., Michel T. Molecular cloning and characterization of human endothelial nitric oxide synthase. FEBS Lett. 1992 Aug 3;307(3):287–293. doi: 10.1016/0014-5793(92)80697-f. [DOI] [PubMed] [Google Scholar]
  138. Martin E., Nathan C., Xie Q. W. Role of interferon regulatory factor 1 in induction of nitric oxide synthase. J Exp Med. 1994 Sep 1;180(3):977–984. doi: 10.1084/jem.180.3.977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  139. Matheis G., Sherman M. P., Buckberg G. D., Haybron D. M., Young H. H., Ignarro L. J. Role of L-arginine-nitric oxide pathway in myocardial reoxygenation injury. Am J Physiol. 1992 Feb;262(2 Pt 2):H616–H620. doi: 10.1152/ajpheart.1992.262.2.H616. [DOI] [PubMed] [Google Scholar]
  140. Mayer B., John M., Böhme E. Purification of a Ca2+/calmodulin-dependent nitric oxide synthase from porcine cerebellum. Cofactor-role of tetrahydrobiopterin. FEBS Lett. 1990 Dec 17;277(1-2):215–219. doi: 10.1016/0014-5793(90)80848-d. [DOI] [PubMed] [Google Scholar]
  141. Mayhan W. G. Role of nitric oxide in modulating permeability of hamster cheek pouch in response to adenosine 5'-diphosphate and bradykinin. Inflammation. 1992 Aug;16(4):295–305. doi: 10.1007/BF00917622. [DOI] [PubMed] [Google Scholar]
  142. McCall T. B., Palmer R. M., Moncada S. Interleukin-8 inhibits the induction of nitric oxide synthase in rat peritoneal neutrophils. Biochem Biophys Res Commun. 1992 Jul 31;186(2):680–685. doi: 10.1016/0006-291x(92)90800-z. [DOI] [PubMed] [Google Scholar]
  143. McCartney-Francis N., Allen J. B., Mizel D. E., Albina J. E., Xie Q. W., Nathan C. F., Wahl S. M. Suppression of arthritis by an inhibitor of nitric oxide synthase. J Exp Med. 1993 Aug 1;178(2):749–754. doi: 10.1084/jem.178.2.749. [DOI] [PMC free article] [PubMed] [Google Scholar]
  144. Messmer U. K., Ankarcrona M., Nicotera P., Brüne B. p53 expression in nitric oxide-induced apoptosis. FEBS Lett. 1994 Nov 21;355(1):23–26. doi: 10.1016/0014-5793(94)01161-3. [DOI] [PubMed] [Google Scholar]
  145. Middleton S. J., Shorthouse M., Hunter J. O. Increased nitric oxide synthesis in ulcerative colitis. Lancet. 1993 Feb 20;341(8843):465–466. doi: 10.1016/0140-6736(93)90211-x. [DOI] [PubMed] [Google Scholar]
  146. Miller M. J., Sadowska-Krowicka H., Chotinaruemol S., Kakkis J. L., Clark D. A. Amelioration of chronic ileitis by nitric oxide synthase inhibition. J Pharmacol Exp Ther. 1993 Jan;264(1):11–16. [PubMed] [Google Scholar]
  147. Miller M. J., Zhang X. J., Sadowska-Krowicka H., Chotinaruemol S., McIntyre J. A., Clark D. A., Bustamante S. A. Nitric oxide release in response to gut injury. Scand J Gastroenterol. 1993 Feb;28(2):149–154. doi: 10.3109/00365529309096062. [DOI] [PubMed] [Google Scholar]
  148. Mills C. D. Molecular basis of "suppressor" macrophages. Arginine metabolism via the nitric oxide synthetase pathway. J Immunol. 1991 Apr 15;146(8):2719–2723. [PubMed] [Google Scholar]
  149. Mills C. D., Shearer J., Evans R., Caldwell M. D. Macrophage arginine metabolism and the inhibition or stimulation of cancer. J Immunol. 1992 Oct 15;149(8):2709–2714. [PubMed] [Google Scholar]
  150. Moore P. K., Oluyomi A. O., Babbedge R. C., Wallace P., Hart S. L. L-NG-nitro arginine methyl ester exhibits antinociceptive activity in the mouse. Br J Pharmacol. 1991 Jan;102(1):198–202. doi: 10.1111/j.1476-5381.1991.tb12153.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  151. Mulligan M. S., Hevel J. M., Marletta M. A., Ward P. A. Tissue injury caused by deposition of immune complexes is L-arginine dependent. Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6338–6342. doi: 10.1073/pnas.88.14.6338. [DOI] [PMC free article] [PubMed] [Google Scholar]
  152. Mulligan M. S., Warren J. S., Smith C. W., Anderson D. C., Yeh C. G., Rudolph A. R., Ward P. A. Lung injury after deposition of IgA immune complexes. Requirements for CD18 and L-arginine. J Immunol. 1992 May 15;148(10):3086–3092. [PubMed] [Google Scholar]
  153. Muñoz-Fernández M. A., Fernández M. A., Fresno M. Synergism between tumor necrosis factor-alpha and interferon-gamma on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide-dependent mechanism. Eur J Immunol. 1992 Feb;22(2):301–307. doi: 10.1002/eji.1830220203. [DOI] [PubMed] [Google Scholar]
  154. Najafipour H., Ferrell W. R. Nitric oxide modulates sympathetic vasoconstriction and basal blood flow in normal and acutely inflamed rabbit knee joints. Exp Physiol. 1993 Sep;78(5):615–624. doi: 10.1113/expphysiol.1993.sp003710. [DOI] [PubMed] [Google Scholar]
  155. Nava E., Palmer R. M., Moncada S. Inhibition of nitric oxide synthesis in septic shock: how much is beneficial? Lancet. 1991 Dec 21;338(8782-8783):1555–1557. doi: 10.1016/0140-6736(91)92375-c. [DOI] [PubMed] [Google Scholar]
  156. Nelson B. J., Ralph P., Green S. J., Nacy C. A. Differential susceptibility of activated macrophage cytotoxic effector reactions to the suppressive effects of transforming growth factor-beta 1. J Immunol. 1991 Mar 15;146(6):1849–1857. [PubMed] [Google Scholar]
  157. Nguyen T., Brunson D., Crespi C. L., Penman B. W., Wishnok J. S., Tannenbaum S. R. DNA damage and mutation in human cells exposed to nitric oxide in vitro. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3030–3034. doi: 10.1073/pnas.89.7.3030. [DOI] [PMC free article] [PubMed] [Google Scholar]
  158. Nishida K., Harrison D. G., Navas J. P., Fisher A. A., Dockery S. P., Uematsu M., Nerem R. M., Alexander R. W., Murphy T. J. Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. J Clin Invest. 1992 Nov;90(5):2092–2096. doi: 10.1172/JCI116092. [DOI] [PMC free article] [PubMed] [Google Scholar]
  159. Northington F. J., Matherne G. P., Berne R. M. Competitive inhibition of nitric oxide synthase prevents the cortical hyperemia associated with peripheral nerve stimulation. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6649–6652. doi: 10.1073/pnas.89.14.6649. [DOI] [PMC free article] [PubMed] [Google Scholar]
  160. O'Dell T. J., Hawkins R. D., Kandel E. R., Arancio O. Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11285–11289. doi: 10.1073/pnas.88.24.11285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  161. Ochoa J. B., Udekwu A. O., Billiar T. R., Curran R. D., Cerra F. B., Simmons R. L., Peitzman A. B. Nitrogen oxide levels in patients after trauma and during sepsis. Ann Surg. 1991 Nov;214(5):621–626. doi: 10.1097/00000658-199111000-00013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  162. Oswald I. P., Gazzinelli R. T., Sher A., James S. L. IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity. J Immunol. 1992 Jun 1;148(11):3578–3582. [PubMed] [Google Scholar]
  163. Palacios M., Knowles R. G., Palmer R. M., Moncada S. Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands. Biochem Biophys Res Commun. 1989 Dec 15;165(2):802–809. doi: 10.1016/s0006-291x(89)80037-3. [DOI] [PubMed] [Google Scholar]
  164. Palmer R. M., Andrews T., Foxwell N. A., Moncada S. Glucocorticoids do not affect the induction of a novel calcium-dependent nitric oxide synthase in rabbit chondrocytes. Biochem Biophys Res Commun. 1992 Oct 15;188(1):209–215. doi: 10.1016/0006-291x(92)92371-4. [DOI] [PubMed] [Google Scholar]
  165. Palmer R. M., Ashton D. S., Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature. 1988 Jun 16;333(6174):664–666. doi: 10.1038/333664a0. [DOI] [PubMed] [Google Scholar]
  166. Palmer R. M., Ferrige A. G., Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 1987 Jun 11;327(6122):524–526. doi: 10.1038/327524a0. [DOI] [PubMed] [Google Scholar]
  167. Palmer R. M., Hickery M. S., Charles I. G., Moncada S., Bayliss M. T. Induction of nitric oxide synthase in human chondrocytes. Biochem Biophys Res Commun. 1993 May 28;193(1):398–405. doi: 10.1006/bbrc.1993.1637. [DOI] [PubMed] [Google Scholar]
  168. Pape H. C., Mager R. Nitric oxide controls oscillatory activity in thalamocortical neurons. Neuron. 1992 Sep;9(3):441–448. doi: 10.1016/0896-6273(92)90182-d. [DOI] [PubMed] [Google Scholar]
  169. Park K. G., Hayes P. D., Garlick P. J., Sewell H., Eremin O. Stimulation of lymphocyte natural cytotoxicity by L-arginine. Lancet. 1991 Mar 16;337(8742):645–646. doi: 10.1016/0140-6736(91)92456-c. [DOI] [PubMed] [Google Scholar]
  170. Persson M. G., Gustafsson L. E., Wiklund N. P., Moncada S., Hedqvist P. Endogenous nitric oxide as a probable modulator of pulmonary circulation and hypoxic pressor response in vivo. Acta Physiol Scand. 1990 Dec;140(4):449–457. doi: 10.1111/j.1748-1716.1990.tb09021.x. [DOI] [PubMed] [Google Scholar]
  171. Petros A., Bennett D., Vallance P. Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet. 1991 Dec 21;338(8782-8783):1557–1558. doi: 10.1016/0140-6736(91)92376-d. [DOI] [PubMed] [Google Scholar]
  172. Petros A., Lamb G., Leone A., Moncada S., Bennett D., Vallance P. Effects of a nitric oxide synthase inhibitor in humans with septic shock. Cardiovasc Res. 1994 Jan;28(1):34–39. doi: 10.1093/cvr/28.1.34. [DOI] [PubMed] [Google Scholar]
  173. Radomski M. W., Palmer R. M., Moncada S. An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci U S A. 1990 Jul;87(13):5193–5197. doi: 10.1073/pnas.87.13.5193. [DOI] [PMC free article] [PubMed] [Google Scholar]
  174. Radomski M. W., Palmer R. M., Moncada S. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet. 1987 Nov 7;2(8567):1057–1058. doi: 10.1016/s0140-6736(87)91481-4. [DOI] [PubMed] [Google Scholar]
  175. Radomski M. W., Palmer R. M., Moncada S. Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc Natl Acad Sci U S A. 1990 Dec;87(24):10043–10047. doi: 10.1073/pnas.87.24.10043. [DOI] [PMC free article] [PubMed] [Google Scholar]
  176. Radomski M. W., Palmer R. M., Moncada S. The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide. Br J Pharmacol. 1987 Nov;92(3):639–646. doi: 10.1111/j.1476-5381.1987.tb11367.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  177. Ralston S. H., Todd D., Helfrich M., Benjamin N., Grabowski P. S. Human osteoblast-like cells produce nitric oxide and express inducible nitric oxide synthase. Endocrinology. 1994 Jul;135(1):330–336. doi: 10.1210/endo.135.1.7516867. [DOI] [PubMed] [Google Scholar]
  178. Reif D. W., Simmons R. D. Nitric oxide mediates iron release from ferritin. Arch Biochem Biophys. 1990 Dec;283(2):537–541. doi: 10.1016/0003-9861(90)90680-w. [DOI] [PubMed] [Google Scholar]
  179. Rengasamy A., Johns R. A. Regulation of nitric oxide synthase by nitric oxide. Mol Pharmacol. 1993 Jul;44(1):124–128. [PubMed] [Google Scholar]
  180. Robert A., Leung F. W., Kaiser D. G., Guth P. H. Potentiation of aspirin-induced gastric lesions by exposure to cold in rats. Role of acid secretion, mucosal blood flow, and gastric mucosal prostanoid content. Gastroenterology. 1989 Nov;97(5):1147–1158. doi: 10.1016/0016-5085(89)91684-3. [DOI] [PubMed] [Google Scholar]
  181. Roberts J. D., Polaner D. M., Lang P., Zapol W. M. Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Lancet. 1992 Oct 3;340(8823):818–819. doi: 10.1016/0140-6736(92)92686-a. [DOI] [PubMed] [Google Scholar]
  182. Rockett K. A., Awburn M. M., Cowden W. B., Clark I. A. Killing of Plasmodium falciparum in vitro by nitric oxide derivatives. Infect Immun. 1991 Sep;59(9):3280–3283. doi: 10.1128/iai.59.9.3280-3283.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  183. Rosenberg S. A., Lotze M. T., Yang J. C., Aebersold P. M., Linehan W. M., Seipp C. A., White D. E. Experience with the use of high-dose interleukin-2 in the treatment of 652 cancer patients. Ann Surg. 1989 Oct;210(4):474–485. doi: 10.1097/00000658-198910000-00008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  184. Rossaint R., Falke K. J., López F., Slama K., Pison U., Zapol W. M. Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med. 1993 Feb 11;328(6):399–405. doi: 10.1056/NEJM199302113280605. [DOI] [PubMed] [Google Scholar]
  185. Sakuma I., Togashi H., Yoshioka M., Saito H., Yanagida M., Tamura M., Kobayashi T., Yasuda H., Gross S. S., Levi R. NG-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo. A role for nitric oxide in the central regulation of sympathetic tone? Circ Res. 1992 Mar;70(3):607–611. doi: 10.1161/01.res.70.3.607. [DOI] [PubMed] [Google Scholar]
  186. Salvemini D., Masini E., Anggard E., Mannaioni P. F., Vane J. Synthesis of a nitric oxide-like factor from L-arginine by rat serosal mast cells: stimulation of guanylate cyclase and inhibition of platelet aggregation. Biochem Biophys Res Commun. 1990 Jun 15;169(2):596–601. doi: 10.1016/0006-291x(90)90372-t. [DOI] [PubMed] [Google Scholar]
  187. Sanna A., Kurtansky A., Veriter C., Stănescu D. Bronchodilator effect of inhaled nitric oxide in healthy men. Am J Respir Crit Care Med. 1994 Dec;150(6 Pt 1):1702–1704. doi: 10.1164/ajrccm.150.6.7952636. [DOI] [PubMed] [Google Scholar]
  188. Schilling J., Cakmakci M., Bättig U., Geroulanos S. A new approach in the treatment of hypotension in human septic shock by NG-monomethyl-L-arginine, an inhibitor of the nitric oxide synthetase. Intensive Care Med. 1993;19(4):227–231. doi: 10.1007/BF01694775. [DOI] [PubMed] [Google Scholar]
  189. Schmidt K., Graier W. F., Kostner G. M., Mayer B., Kukovetz W. R. Activation of soluble guanylate cyclase by nitrovasodilators is inhibited by oxidized low-density lipoprotein. Biochem Biophys Res Commun. 1990 Oct 30;172(2):614–619. doi: 10.1016/0006-291x(90)90718-3. [DOI] [PubMed] [Google Scholar]
  190. Scholz H., Kurtz A. Involvement of endothelium-derived relaxing factor in the pressure control of renin secretion from isolated perfused kidney. J Clin Invest. 1993 Mar;91(3):1088–1094. doi: 10.1172/JCI116266. [DOI] [PMC free article] [PubMed] [Google Scholar]
  191. Sessa W. C., Harrison J. K., Barber C. M., Zeng D., Durieux M. E., D'Angelo D. D., Lynch K. R., Peach M. J. Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase. J Biol Chem. 1992 Aug 5;267(22):15274–15276. [PubMed] [Google Scholar]
  192. Shi Y., Li H. Q., Shen C. K., Wang J. H., Qin S. W., Liu R., Pan J. Plasma nitric oxide levels in newborn infants with sepsis. J Pediatr. 1993 Sep;123(3):435–438. doi: 10.1016/s0022-3476(05)81753-6. [DOI] [PubMed] [Google Scholar]
  193. Shibuki K., Okada D. Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum. Nature. 1991 Jan 24;349(6307):326–328. doi: 10.1038/349326a0. [DOI] [PubMed] [Google Scholar]
  194. Southern C., Schulster D., Green I. C. Inhibition of insulin secretion by interleukin-1 beta and tumour necrosis factor-alpha via an L-arginine-dependent nitric oxide generating mechanism. FEBS Lett. 1990 Dec 10;276(1-2):42–44. doi: 10.1016/0014-5793(90)80502-a. [DOI] [PubMed] [Google Scholar]
  195. Stadler J., Stefanovic-Racic M., Billiar T. R., Curran R. D., McIntyre L. A., Georgescu H. I., Simmons R. L., Evans C. H. Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide. J Immunol. 1991 Dec 1;147(11):3915–3920. [PubMed] [Google Scholar]
  196. Steinberg D., Parthasarathy S., Carew T. E., Khoo J. C., Witztum J. L. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med. 1989 Apr 6;320(14):915–924. doi: 10.1056/NEJM198904063201407. [DOI] [PubMed] [Google Scholar]
  197. Sternberg J., McGuigan F. Nitric oxide mediates suppression of T cell responses in murine Trypanosoma brucei infection. Eur J Immunol. 1992 Oct;22(10):2741–2744. doi: 10.1002/eji.1830221041. [DOI] [PubMed] [Google Scholar]
  198. Stuehr D. J., Cho H. J., Kwon N. S., Weise M. F., Nathan C. F. Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein. Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7773–7777. doi: 10.1073/pnas.88.17.7773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  199. Stuehr D. J., Nathan C. F. Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J Exp Med. 1989 May 1;169(5):1543–1555. doi: 10.1084/jem.169.5.1543. [DOI] [PMC free article] [PubMed] [Google Scholar]
  200. Taskiran D., Stefanovic-Racic M., Georgescu H., Evans C. Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1. Biochem Biophys Res Commun. 1994 Apr 15;200(1):142–148. doi: 10.1006/bbrc.1994.1426. [DOI] [PubMed] [Google Scholar]
  201. Thiemermann C., Vane J. Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo. Eur J Pharmacol. 1990 Jul 17;182(3):591–595. doi: 10.1016/0014-2999(90)90062-b. [DOI] [PubMed] [Google Scholar]
  202. Thomsen L. L., Ching L. M., Baguley B. C. Evidence for the production of nitric oxide by activated macrophages treated with the antitumor agents flavone-8-acetic acid and xanthenone-4-acetic acid. Cancer Res. 1990 Nov 1;50(21):6966–6970. [PubMed] [Google Scholar]
  203. Toda N., Okamura T. Modification by L-NG-monomethyl arginine (L-NMMA) of the response to nerve stimulation in isolated dog mesenteric and cerebral arteries. Jpn J Pharmacol. 1990 Jan;52(1):170–173. doi: 10.1254/jjp.52.170. [DOI] [PubMed] [Google Scholar]
  204. Trifiletti R. R. Neuroprotective effects of NG-nitro-L-arginine in focal stroke in the 7-day old rat. Eur J Pharmacol. 1992 Jul 21;218(1):197–198. doi: 10.1016/0014-2999(92)90168-4. [DOI] [PubMed] [Google Scholar]
  205. Tøttrup A., Svane D., Forman A. Nitric oxide mediating NANC inhibition in opossum lower esophageal sphincter. Am J Physiol. 1991 Mar;260(3 Pt 1):G385–G389. doi: 10.1152/ajpgi.1991.260.3.G385. [DOI] [PubMed] [Google Scholar]
  206. Uemura Y., Kowall N. W., Beal M. F. Selective sparing of NADPH-diaphorase-somatostatin-neuropeptide Y neurons in ischemic gerbil striatum. Ann Neurol. 1990 Jun;27(6):620–625. doi: 10.1002/ana.410270606. [DOI] [PubMed] [Google Scholar]
  207. Vallance P., Collier J., Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet. 1989 Oct 28;2(8670):997–1000. doi: 10.1016/s0140-6736(89)91013-1. [DOI] [PubMed] [Google Scholar]
  208. Vallance P., Collier J., Moncada S. Nitric oxide synthesised from L-arginine mediates endothelium dependent dilatation in human veins in vivo. Cardiovasc Res. 1989 Dec;23(12):1053–1057. doi: 10.1093/cvr/23.12.1053. [DOI] [PubMed] [Google Scholar]
  209. Vallance P., Moncada S. Hyperdynamic circulation in cirrhosis: a role for nitric oxide? Lancet. 1991 Mar 30;337(8744):776–778. doi: 10.1016/0140-6736(91)91384-7. [DOI] [PubMed] [Google Scholar]
  210. Venturini C. M., Knowles R. G., Palmer R. M., Moncada S. Synthesis of nitric oxide in the bovine retina. Biochem Biophys Res Commun. 1991 Oct 31;180(2):920–925. doi: 10.1016/s0006-291x(05)81153-2. [DOI] [PubMed] [Google Scholar]
  211. Wakefield A. J., Sawyerr A. M., Dhillon A. P., Pittilo R. M., Rowles P. M., Lewis A. A., Pounder R. E. Pathogenesis of Crohn's disease: multifocal gastrointestinal infarction. Lancet. 1989 Nov 4;2(8671):1057–1062. doi: 10.1016/s0140-6736(89)91078-7. [DOI] [PubMed] [Google Scholar]
  212. Walder C. E., Thiemermann C., Vane J. R. Endothelium-derived relaxing factor participates in the increased blood flow in response to pentagastrin in the rat stomach mucosa. Proc Biol Sci. 1990 Sep 22;241(1302):195–200. doi: 10.1098/rspb.1990.0085. [DOI] [PubMed] [Google Scholar]
  213. Warren J. B., Loi R., Rendell N. B., Taylor G. W. Nitric oxide is inactivated by the bacterial pigment pyocyanin. Biochem J. 1990 Mar 15;266(3):921–923. [PMC free article] [PubMed] [Google Scholar]
  214. Weinberg J. B., Granger D. L., Pisetsky D. S., Seldin M. F., Misukonis M. A., Mason S. N., Pippen A. M., Ruiz P., Wood E. R., Gilkeson G. S. The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine. J Exp Med. 1994 Feb 1;179(2):651–660. doi: 10.1084/jem.179.2.651. [DOI] [PMC free article] [PubMed] [Google Scholar]
  215. Weiss G., Goossen B., Doppler W., Fuchs D., Pantopoulos K., Werner-Felmayer G., Wachter H., Hentze M. W. Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway. EMBO J. 1993 Sep;12(9):3651–3657. doi: 10.1002/j.1460-2075.1993.tb06039.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  216. Werner-Felmayer G., Werner E. R., Fuchs D., Hausen A., Reibnegger G., Wachter H. Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts. J Exp Med. 1990 Dec 1;172(6):1599–1607. doi: 10.1084/jem.172.6.1599. [DOI] [PMC free article] [PubMed] [Google Scholar]
  217. Werns S. W., Walton J. A., Hsia H. H., Nabel E. G., Sanz M. L., Pitt B. Evidence of endothelial dysfunction in angiographically normal coronary arteries of patients with coronary artery disease. Circulation. 1989 Feb;79(2):287–291. doi: 10.1161/01.cir.79.2.287. [DOI] [PubMed] [Google Scholar]
  218. White K. A., Marletta M. A. Nitric oxide synthase is a cytochrome P-450 type hemoprotein. Biochemistry. 1992 Jul 28;31(29):6627–6631. doi: 10.1021/bi00144a001. [DOI] [PubMed] [Google Scholar]
  219. Wink D. A., Kasprzak K. S., Maragos C. M., Elespuru R. K., Misra M., Dunams T. M., Cebula T. A., Koch W. H., Andrews A. W., Allen J. S. DNA deaminating ability and genotoxicity of nitric oxide and its progenitors. Science. 1991 Nov 15;254(5034):1001–1003. doi: 10.1126/science.1948068. [DOI] [PubMed] [Google Scholar]
  220. Wren S. M., Hoffman R. A., Billiar T. R., Abou el Ezz A., Hronakes M. L., Ildstad S. T. T-cell mitogenic responses in fully xenogeneic chimeras (WF rat----B10 mouse) are restored by blocking the L-arginine-dependent nitric oxide pathway. Transplant Proc. 1992 Apr;24(2):499–500. [PubMed] [Google Scholar]
  221. Xie Q. W., Cho H. J., Calaycay J., Mumford R. A., Swiderek K. M., Lee T. D., Ding A., Troso T., Nathan C. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science. 1992 Apr 10;256(5054):225–228. doi: 10.1126/science.1373522. [DOI] [PubMed] [Google Scholar]
  222. Xie Q. W., Whisnant R., Nathan C. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide. J Exp Med. 1993 Jun 1;177(6):1779–1784. doi: 10.1084/jem.177.6.1779. [DOI] [PMC free article] [PubMed] [Google Scholar]
  223. Yang G., Candy T. E., Boaro M., Wilkin H. E., Jones P., Nazhat N. B., Saadalla-Nazhat R. A., Blake D. R. Free radical yields from the homolysis of peroxynitrous acid. Free Radic Biol Med. 1992;12(4):327–330. doi: 10.1016/0891-5849(92)90120-6. [DOI] [PubMed] [Google Scholar]
  224. Yao S. K., Ober J. C., Krishnaswami A., Ferguson J. J., Anderson H. V., Golino P., Buja L. M., Willerson J. T. Endogenous nitric oxide protects against platelet aggregation and cyclic flow variations in stenosed and endothelium-injured arteries. Circulation. 1992 Oct;86(4):1302–1309. doi: 10.1161/01.cir.86.4.1302. [DOI] [PubMed] [Google Scholar]
  225. Yates M. T., Lambert L. E., Whitten J. P., McDonald I., Mano M., Ku G., Mao S. J. A protective role for nitric oxide in the oxidative modification of low density lipoproteins by mouse macrophages. FEBS Lett. 1992 Sep 7;309(2):135–138. doi: 10.1016/0014-5793(92)81081-v. [DOI] [PubMed] [Google Scholar]
  226. Yui Y., Hattori R., Kosuga K., Eizawa H., Hiki K., Kawai C. Purification of nitric oxide synthase from rat macrophages. J Biol Chem. 1991 Jul 5;266(19):12544–12547. [PubMed] [Google Scholar]
  227. Yui Y., Hattori R., Kosuga K., Eizawa H., Hiki K., Ohkawa S., Ohnishi K., Terao S., Kawai C. Calmodulin-independent nitric oxide synthase from rat polymorphonuclear neutrophils. J Biol Chem. 1991 Feb 25;266(6):3369–3371. [PubMed] [Google Scholar]
  228. Zweier J. L. Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury. J Biol Chem. 1988 Jan 25;263(3):1353–1357. [PubMed] [Google Scholar]
  229. al-Ramadi B. K., Meissler J. J., Jr, Huang D., Eisenstein T. K. Immunosuppression induced by nitric oxide and its inhibition by interleukin-4. Eur J Immunol. 1992 Sep;22(9):2249–2254. doi: 10.1002/eji.1830220911. [DOI] [PubMed] [Google Scholar]
  230. de Vente J., Bol J. G., Steinbusch H. W. Localization of cGMP in the cerebellum of the adult rat: an immunohistochemical study. Brain Res. 1989 Dec 18;504(2):332–337. doi: 10.1016/0006-8993(89)91380-2. [DOI] [PubMed] [Google Scholar]

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