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. 1996 Jan;55(1):25–29. doi: 10.1136/ard.55.1.25

Association of hand and knee osteoarthritis: evidence for a polyarticular disease subset.

R Hirsch 1, M Lethbridge-Cejku 1, W W Scott Jr 1, R Reichle 1, C C Plato 1, J Tobin 1, M C Hochberg 1
PMCID: PMC1010077  PMID: 8572729

Abstract

OBJECTIVE--To examine the association between hand and knee osteoarthritis (OA) in a community based population. METHODS--Radiographs of 695 participants aged > or = 40 years in the Baltimore Longitudinal Study of Aging were read for changes of OA, using Kellgren-Lawrence grade > or = 2 as the case definition. RESULTS--Logistic regression analyses, adjusting for age, gender and body mass index, revealed a significant association between OA in the knee and the following joint groups: distal and proximal interphalangeal (DIP, PIP) and Hand2 (OA in two or more hand joint groups) for grade 2-4 and grade 3-4 disease, and the first carpometacarpal (CMC1) joint for grade 3-4 disease. CONCLUSION--There is an association between OA in hand sites and the knee. The strength of the associations increases with increasing disease severity. For the PIP site, there is a trend toward increasing strength of association for increasing numbers of affected joints and bilateral disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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