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. 1984 Nov;141(5):691–694.

The Disuse Syndrome

Walter M Bortz II
PMCID: PMC1011199  PMID: 6516349

Abstract

Our cultural sedentariness, recently acquired, lies at the base of much human ill-being. Physical inactivity predictably leads to deterioration of many body functions. A number of these effects coexist so frequently in our society that they merit inclusion in a specific syndrome, the disuse syndrome. The identifying characteristics of the syndrome are cardiovascular vulnerability, obesity, musculoskeletal fragility, depression and premature aging. The syndrome is experimentally reproducible and, significantly, the clinical features are subject to both preventive and restitutive efforts that happily are cheap, safe, accessible and effective.

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Selected References

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  1. Barański S., Kwarecki K., Szmigielski S., Rozyński J. Histochemistry of skeletal muscle fibres in rats undergoing long-term experimental hypokinesia. Folia Histochem Cytochem (Krakow) 1971;9(4):381–386. [PubMed] [Google Scholar]
  2. Bortz W. M., 2nd Disuse and aging. JAMA. 1982 Sep 10;248(10):1203–1208. [PubMed] [Google Scholar]
  3. Bortz W. M. Disuse--the third dimension. J Am Geriatr Soc. 1982 Dec;30(12):733–733. doi: 10.1111/j.1532-5415.1982.tb03361.x. [DOI] [PubMed] [Google Scholar]
  4. Bortz W. M. Metabolic consequences of obesity. Ann Intern Med. 1969 Oct;71(4):833–843. doi: 10.7326/0003-4819-71-4-833. [DOI] [PubMed] [Google Scholar]
  5. Briggs M. H., Garcia-Webb P., Cheung T. Androgens and exercise. Br Med J. 1973 Jul 7;3(5870):49–50. doi: 10.1136/bmj.3.5870.49-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cockett A. T., Elbadawi A., Zemjanis R., Adey W. R. The effects of immobilization on spermatogenesis in subhuman primates. Fertil Steril. 1970 Aug;21(8):610–614. doi: 10.1016/s0015-0282(16)37685-3. [DOI] [PubMed] [Google Scholar]
  7. Corrodi H., Fuxe K., Hökfelt T. The effect of immobilization stress on the activity of central monoamine neurons. Life Sci. 1968 Jan 1;7(1):107–112. doi: 10.1016/0024-3205(68)90368-8. [DOI] [PubMed] [Google Scholar]
  8. Cutler W. B., Garcia C. R., Krieger A. M. Sexual behavior frequency and menstrual cycle length in mature premenopausal women. Psychoneuroendocrinology. 1979 Oct;4(4):297–309. doi: 10.1016/0306-4530(79)90014-3. [DOI] [PubMed] [Google Scholar]
  9. Dehn M. M., Bruce R. A. Longitudinal variations in maximal oxygen intake with age and activity. J Appl Physiol. 1972 Dec;33(6):805–807. doi: 10.1152/jappl.1972.33.6.805. [DOI] [PubMed] [Google Scholar]
  10. Donaldson C. L., Hulley S. B., Vogel J. M., Hattner R. S., Bayers J. H., McMillan D. E. Effect of prolonged bed rest on bone mineral. Metabolism. 1970 Dec;19(12):1071–1084. doi: 10.1016/0026-0495(70)90032-6. [DOI] [PubMed] [Google Scholar]
  11. Feldman E. J., Dowling R. H., McNaughton J., Peters T. J. Effects of oral versus intravenous nutrition on intestinal adaptation after small bowel resection in the dog. Gastroenterology. 1976 May;70(5 PT1):712–719. [PubMed] [Google Scholar]
  12. Fenyö G., Backman L., Hallberg D. Morphological changes of the small intestine following jejuno-ileal shunt in obese subjects. Acta Chir Scand. 1976;142(2):154–159. [PubMed] [Google Scholar]
  13. GOODALL M., MCCALLY M., GRAVELINE D. E. URINARY ADRENALINE AND NORADRENALINE RESPONSE TO SIMULATED WEIGHTLESS STATE. Am J Physiol. 1964 Feb;206:431–436. doi: 10.1152/ajplegacy.1964.206.2.431. [DOI] [PubMed] [Google Scholar]
  14. Goodrick C. L. Effects of long-term voluntary wheel exercise on male and female Wistar rats. I. Longevity, body weight, and metabolic rate. Gerontology. 1980;26(1):22–33. doi: 10.1159/000212390. [DOI] [PubMed] [Google Scholar]
  15. Harrison E. G., Jr, McCormack L. J. Pathologic classification of renal arterial disease in renovascular hypertension. Mayo Clin Proc. 1971 Mar;46(3):161–167. [PubMed] [Google Scholar]
  16. Hyatt K. H., Kamenetsky L. G., Smith W. M. Extravascular dehydration as an etiologic factor in post-recumbency orthostatism. Aerosp Med. 1969 Jun;40(6):644–650. [PubMed] [Google Scholar]
  17. Kursh E. D., Freehafer A., Persky L. Complications of autonomic dysreflexia. J Urol. 1977 Jul;118(1 Pt 1):70–72. doi: 10.1016/s0022-5347(17)57892-1. [DOI] [PubMed] [Google Scholar]
  18. Lipman R. L., Raskin P., Love T., Triebwasser J., Lecocq F. R., Schnure J. J. Glucose intolerance during decreased physical activity in man. Diabetes. 1972 Feb;21(2):101–107. doi: 10.2337/diab.21.2.101. [DOI] [PubMed] [Google Scholar]
  19. MAYER J. Decreased activity and energy balance in the hereditary obesity-diabetes syndrome of mice. Science. 1953 May 8;117(3045):504–505. doi: 10.1126/science.117.3045.504. [DOI] [PubMed] [Google Scholar]
  20. Mack P. B., Montgomery K. B. Study of nitrogen balance and creatine and creatinine excretion during recumbency and ambulation of five young adult human males. Aerosp Med. 1973 Jul;44(7):739–746. [PubMed] [Google Scholar]
  21. Page N. Weightlessness: a matter of gravity. N Engl J Med. 1977 Jul 7;297(1):32–37. doi: 10.1056/NEJM197707072970106. [DOI] [PubMed] [Google Scholar]
  22. Pfeiffer C. J. Gastrointestinal response fo malnutrition and starvation. Postgrad Med. 1970 Apr;47(4):110–115. doi: 10.1080/00325481.1970.11697442. [DOI] [PubMed] [Google Scholar]
  23. Soman V. R., Koivisto V. A., Deibert D., Felig P., DeFronzo R. A. Increased insulin sensitivity and insulin binding to monocytes after physical training. N Engl J Med. 1979 Nov 29;301(22):1200–1204. doi: 10.1056/NEJM197911293012203. [DOI] [PubMed] [Google Scholar]
  24. Tomanek R. J., Lund D. D. Degeneration of different types of skeletal muscle fibres. I. Denervation. J Anat. 1973 Dec;116(Pt 3):395–407. [PMC free article] [PubMed] [Google Scholar]
  25. Vernikos-Danellis J., Leach C. S., Winget C. M., Rambaut P. C., Mack P. B. Thyroid and adrenal cortical rhythmicity during bed rest. J Appl Physiol. 1972 Nov;33(5):644–648. doi: 10.1152/jappl.1972.33.5.644. [DOI] [PubMed] [Google Scholar]
  26. Williams R. S., Logue E. E., Lewis J. G., Barton T., Stead N. W., Wallace A. G., Pizzo S. V. Physical conditioning augments the fibrinolytic response to venous occlusion in healthy adults. N Engl J Med. 1980 May 1;302(18):987–991. doi: 10.1056/NEJM198005013021802. [DOI] [PubMed] [Google Scholar]
  27. Wood P. D., Haskell W., Klein H., Lewis S., Stern M. P., Farquhar J. W. The distribution of plasma lipoproteins in middle-aged male runners. Metabolism. 1976 Nov;25(11):1249–1257. doi: 10.1016/s0026-0495(76)80008-x. [DOI] [PubMed] [Google Scholar]
  28. ZUBEK J. P., WILGOSH L. Prolonged immobilization of the body: changes in performance and in the electroencephalogram. Science. 1963 Apr 19;140(3564):306–308. doi: 10.1126/science.140.3564.306. [DOI] [PubMed] [Google Scholar]

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