Abstract
A serum amoxycillin concentration of 0.11 g/l was established as being treponemicidal in a rabbit model with orchitis. Seventeen patients treated with amoxycillin 2 g by mouth three times a day plus 500 mg probenecid twice a day attained treponemicidal CSF amoxycillin concentrations. Thus amoxycillin by mouth offers an effective alternative method for treating patients with neurosyphilis.
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Selected References
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- Bennett J. V., Brodie J. L., Benner E. J., Kirby W. M. Simplified, accurate method for antibiotic assay of clinical specimens. Appl Microbiol. 1966 Mar;14(2):170–177. doi: 10.1128/am.14.2.170-177.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Clumeck N., Thys J. P., Vanhoof R., Vanderlinden M. P., Butzler J. P., Yourassowsky E. Amoxicillin entry into human cerebrospinal fluid: comparison with ampicillin. Antimicrob Agents Chemother. 1978 Oct;14(4):531–532. doi: 10.1128/aac.14.4.531. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dunlop E. M., Al-Egaily S. S., Houang E. T. Penicillin levels in blood and CSF achieved by treatment of syphilis. JAMA. 1979 Jun 8;241(23):2538–2540. [PubMed] [Google Scholar]
- Faber W. R., Bos J. D., Rietra P. J., Fass H., Van Eijk R. V. Treponemicidal levels of amoxicillin in cerebrospinal fluid after oral administration. Sex Transm Dis. 1983 Jul-Sep;10(3):148–150. doi: 10.1097/00007435-198307000-00011. [DOI] [PubMed] [Google Scholar]
- Greene B. M., Miller N. R., Bynum T. E. Failure of penicillin G benzathine in the treatment of neurosyphilis. Arch Intern Med. 1980 Aug;140(8):1117–1118. [PubMed] [Google Scholar]
- Mohr J. A., Griffiths W., Jackson R., Saadah H., Bird P., Riddle J. Neurosyphilis and penicillin levels in cerebrospinal fluid. JAMA. 1976 Nov 8;236(19):2208–2209. [PubMed] [Google Scholar]
- Moskovitz B. L., Klimek J. J., Goldman R. L., Fiumara N. J., Quintiliani R. Meningovascular syphilis after 'appropriate' treatment of primary syphilis. Arch Intern Med. 1982 Jan;142(1):139–140. [PubMed] [Google Scholar]
- Simon R. P. Neurosyphilis: an update. West J Med. 1981 Jan;134(1):87–91. [PMC free article] [PubMed] [Google Scholar]