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. 1992 Nov;51(11):1254–1256. doi: 10.1136/ard.51.11.1254

Complement factor 2 deficiency: a clinical and serological family study.

D D'Cruz 1, J Taylor 1, T Ahmed 1, R Asherson 1, M Khamashta 1, G R Hughes 1
PMCID: PMC1012468  PMID: 1361318

Abstract

Inherited complement deficiencies are associated with a variety of connective tissue diseases. A family with inherited deficiency of complement factor 2 (C2) is described in which two family members with homozygous C2 deficiency developed cutaneous vasculitis and sicca syndrome. The other family members had heterozygous C2 deficiency and each member had the HLA-A25, B18, DR2 (w15) haplotype. The mother had seropositive rheumatoid arthritis. Further studies showed the presence of cryoglobulins, antibodies against endothelial cells, and anticardiolipin antibodies.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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