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. 1979 Oct;16(5):384–388. doi: 10.1136/jmg.16.5.384

The sex ratio in spina bifida.

W H James
PMCID: PMC1012615  PMID: 390150

Abstract

Published reports on the sex ratio of spina bifida have been reviewed. With one exception, there seems to be no evidence of variation in the sex ratio of spina bifida. In particular, unlike anencephaly, the sex ratio of spina bifida seems to be unrelated to the prevalence of the malformation: this (M/(M+F)) is of the order of 0.44 in respect of all spina bifida births (liveborn and stillborn). The sex ratio of spina bifida in Negroes does not seem to differ from that in whites (though the data on this point are not numerous). The exception noted above concerns spina bifida occurrring in twins: these cases are disproportionately often female. The point stands in need of explanation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALTER M. Anencephalus, hydrocephalus, and spina bifida. Epidemiology, with special reference to a survey in Charleston, S.C. Arch Neurol. 1962 Nov;7:411–422. doi: 10.1001/archneur.1962.04210050047005. [DOI] [PubMed] [Google Scholar]
  2. BOOK J. A. The incidence of congenital diseases and defects in a south Swedish population. Acta Genet Stat Med. 1951;2(4):289–311. [PubMed] [Google Scholar]
  3. CONWAY H., WAGNER K. J. CONGENITAL ANOMALIES OF THE HEAD AND NECK AS REPORTED ON BIRTH CERTIFICATES IN NEW YORK CITY, 1952 TO 1962 (INCLUSIVE). Plast Reconstr Surg. 1965 Jul;36:71–79. [PubMed] [Google Scholar]
  4. Carter C. O., David P. A., Laurence K. M. A family study of major central nervous system malformations in South Wales. J Med Genet. 1968 Jun;5(2):81–106. doi: 10.1136/jmg.5.2.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Carter C. O., Evans K. Spina bifida and anencephalus in greater London. J Med Genet. 1973 Sep;10(3):209–234. doi: 10.1136/jmg.10.3.209. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Czeizel A., Révész C. Major malformations of the central nervous system in Hungary. Br J Prev Soc Med. 1970 Nov;24(4):205–222. doi: 10.1136/jech.24.4.205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. DORAN P. A., GUTHKELCH A. N. Studies in spina bifida cystica. I. General survey and reassessment of the problem. J Neurol Neurosurg Psychiatry. 1961 Nov;24:331–345. doi: 10.1136/jnnp.24.4.331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Elwood J. H. Epidemics of anencephalus and spina bifida in Ireland since 1900. Int J Epidemiol. 1973 Summer;2(2):171–175. doi: 10.1093/ije/2.2.171. [DOI] [PubMed] [Google Scholar]
  9. Elwood J. H., Nevin N. C. Factors associated with anencephalus and spina bifida in Belfast. Br J Prev Soc Med. 1973 May;27(2):73–80. doi: 10.1136/jech.27.2.73. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Field B. Neural tube defects in New South Wales, Australia. J Med Genet. 1978 Oct;15(5):329–338. doi: 10.1136/jmg.15.5.329. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. GITTELSOHN A. M., MILHAM S. Declining incidence of central nervous system anomalies in New York State. Br J Prev Soc Med. 1962 Jul;16:153–158. doi: 10.1136/jech.16.3.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Granroth G., Hakama M., Saxén L. Defects of the central nervous system in Finland: I. Variations in time and space, sex distribution, and parental age. Br J Prev Soc Med. 1977 Sep;31(3):164–170. doi: 10.1136/jech.31.3.164. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hay S. Sex differences in the incidence of certain congenital malformations: a review of the literature and some new data. Teratology. 1971 Aug;4(3):277–286. doi: 10.1002/tera.1420040303. [DOI] [PubMed] [Google Scholar]
  14. Horowitz I., McDonald A. D. Anencephaly and spina bifida in the Province of Quebec. Can Med Assoc J. 1969 Apr 26;100(16):748–755. [PMC free article] [PubMed] [Google Scholar]
  15. IVY R. H. CONGENITAL ANOMALIES. AS RECORDED ON BIRTH CERTIFICATES IN THE DIVISION OF VITAL STATISTICS OF THE PENNSYLVANIA DEPARTMENT OF HEALTH, FOR THE PERIOD OF 1956 TO 1960, INCLUSIVE. Plast Reconstr Surg. 1963 Sep;32:361–367. doi: 10.1097/00006534-196309000-00010. [DOI] [PubMed] [Google Scholar]
  16. IVY R. H. Congenital anomalies; as recorded on birth certificates in the Division of Vital Statistics of the Pennsylvania Department of Health, for the period 1951-1955, inclusive. Plast Reconstr Surg (1946) 1957 Nov;20(5):400–411. [PubMed] [Google Scholar]
  17. James W. H. The sex ratio in anencephaly. J Med Genet. 1979 Apr;16(2):129–133. doi: 10.1136/jmg.16.2.129. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. James W. H. Timing of fertilization and sex ratio of offspring--a review. Ann Hum Biol. 1976 Nov;3(6):549–556. doi: 10.1080/03014467600001811. [DOI] [PubMed] [Google Scholar]
  19. Janerich D. T. Epidemic waves in the prevalence of anencephaly and spina bifida in New York State. Teratology. 1973 Dec;8(3):253–256. doi: 10.1002/tera.1420080304. [DOI] [PubMed] [Google Scholar]
  20. Knox E. G. Twins and neural tube defects. Br J Prev Soc Med. 1974 May;28(2):73–80. doi: 10.1136/jech.28.2.73. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. LENZ W. EPIDEMIOLOGY OF CONGENITAL MALFORMATIONS. Ann N Y Acad Sci. 1965 Mar 12;123:228–236. doi: 10.1111/j.1749-6632.1965.tb12261.x. [DOI] [PubMed] [Google Scholar]
  22. Laurence K. M., Carter C. O., David P. A. Major central nervous system malformations in South Wales. II. Pregnancy factors, seasonal variation, and social class effects. Br J Prev Soc Med. 1968 Oct;22(4):212–222. doi: 10.1136/jech.22.4.212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. MACMAHON B., PUGH T. F., INGALLS T. H. Anencephalus, spina bifida, and hydrocephalus incidence related to sex, race, and season of birth, and incidence in siblings. Br J Prev Soc Med. 1953 Oct;7(4):211–219. doi: 10.1136/jech.7.4.211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. MacMAHON B., RECORD R. G., McKEOWN T. Secular changes in the incidence of malformations of the central nervous system. Br J Soc Med. 1951 Oct;5(4):254–258. doi: 10.1136/jech.5.4.254. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Naggan L. Anencephaly and spina bifida in Israel. Pediatrics. 1971 Mar;47(3):577–586. [PubMed] [Google Scholar]
  26. Naggan L. The recent decline in prevalence of anencephaly and spina bifida. Am J Epidemiol. 1969 Feb;89(2):154–160. doi: 10.1093/oxfordjournals.aje.a120924. [DOI] [PubMed] [Google Scholar]
  27. Roberts A. M. The origins of fluctuations in the human secondary sex ratio. J Biosoc Sci. 1978 Apr;10(2):169–182. doi: 10.1017/s0021932000011597. [DOI] [PubMed] [Google Scholar]
  28. SCHWIDDE J. T. Spina bifida; survey of two hundred twenty-five encephaloceles, meningoceles, and myelomeningoceles. AMA Am J Dis Child. 1952 Jul;84(1):35–51. [PubMed] [Google Scholar]
  29. SMITHELLS R. W., CHINN E. R. SPINA BIFIDA IN LIVERPOOL. Dev Med Child Neurol. 1965 Jun;7:258–268. [PubMed] [Google Scholar]
  30. Siris I. E. SPINA BIFIDA: TREATMENT AND ANALYSIS OF EIGHTY-FOUR CASES. Ann Surg. 1936 Jan;103(1):97–123. doi: 10.1097/00000658-193601000-00012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Spellman M. P. A five year survey in Cork of spina bifida and hydrocephaly. J Ir Med Assoc. 1970 Sep 25;63(399):339–342. [PubMed] [Google Scholar]
  32. Timson J. The sex ratio in Spina bifida. Genetica. 1969;40(3):427–433. doi: 10.1007/BF01787370. [DOI] [PubMed] [Google Scholar]
  33. Westlung K. Mortality from congenital malformations of the central nervous system in Norway, 1951-65. Life insurance companies' institute for medical statistics at the Oslo city hospitals, report no. 12. Br J Prev Soc Med. 1969 Feb;23(1):28–33. doi: 10.1136/jech.23.1.28. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Wilson T. S. Congenital malformations of the central nervous system among Glasgow births 1964-68. Health Bull (Edinb) 1970 Oct;28(4):32–38. [PubMed] [Google Scholar]

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