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. 1979 Apr;16(2):117–121. doi: 10.1136/jmg.16.2.117

Serum creatine kinase levels in pubertal, mature, pregnant, and postmenopausal women.

S Bundey, J M Crawley, J H Edwards, R A Westhead
PMCID: PMC1012734  PMID: 379337

Abstract

In order to obtain control values for the diagnosis of carriers of Duchenne muscular dystrophy, creatine kinase (CK) estimations were performed in two laboratories on 148 healthy teenage girls (of whom 38 were premenarchal and 110 postmenarchal), 133 healthy mature women, 124 pregnant women, and 37 postmenopausal women. These levels were highest in the premenarchal teenagers, and became successively lower in the postmenarchal teenagers, the mature women, and the pregnant women, so that the mean level of the pregnant women was less than half that of the teenagers. The CK levels then rose again after the menopause. If the distribution of CK levels in adult non-pregnant women had been taken as controls for teenagers who were possible carriers for Duchenne muscular dystrophy, then one third of those teenagers classified as carriers would have been so classified incorrectly.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blyth H., Hughes B. P. Pregnancy and serum C.P.K. levels in potential carriers of severe X-linked muscular dystrophy. Lancet. 1971 Apr 24;1(7704):855–856. doi: 10.1016/s0140-6736(71)91520-0. [DOI] [PubMed] [Google Scholar]
  2. Emery A. E., King B. Pregnancy and serum-creatine-kinase levels in potential carriers of Duchenne X-linked muscular dystrophy. Lancet. 1971 May 15;1(7707):1013–1013. doi: 10.1016/s0140-6736(71)91404-8. [DOI] [PubMed] [Google Scholar]
  3. HUGHES B. P. A method for the estimation of serum creatine kinase and its use in comparing creatine kinase and aldolase activity in normal and pathological sera. Clin Chim Acta. 1962 Sep;7:597–603. doi: 10.1016/0009-8981(62)90137-7. [DOI] [PubMed] [Google Scholar]
  4. King B., Spikesman A., Emery A. E. The effect of pregnancy on serum levels of creatine kinase. Clin Chim Acta. 1972 Jan;36(1):267–269. doi: 10.1016/0009-8981(72)90191-x. [DOI] [PubMed] [Google Scholar]
  5. Moser H. Heterozygotenerfassung und genetische Beratung bei der progressiven Muskeldystrophie Duchenne. Schweiz Rundsch Med Prax. 1977 Jul 5;66(27):814–822. [PubMed] [Google Scholar]
  6. Moser H., Vogt J. Letter: Follow-up study of serum-creatine-kinase in carriers of Duchenne muscular dystrophy. Lancet. 1974 Sep 14;2(7881):661–662. doi: 10.1016/s0140-6736(74)91993-x. [DOI] [PubMed] [Google Scholar]
  7. Perry T. B., Fraser F. C. Variability of serum creatine phosphokinase activity in normal women and carriers of the gene for Duchenne muscular dystrophy. Neurology. 1973 Dec;23(12):1316–1323. doi: 10.1212/wnl.23.12.1316. [DOI] [PubMed] [Google Scholar]
  8. Simpson J., Zellweger H., Burmeister L. F., Christee R., Nielsen M. K. Effect of oral contraceptive pills on the level of creatine phosphokinase with regard to carrier detection in Duchenne muscular dystrophy. Clin Chim Acta. 1974 Apr;52(2):219–223. doi: 10.1016/0009-8981(74)90213-7. [DOI] [PubMed] [Google Scholar]
  9. Sweetin J. C., Thomson W. H. Revised normal ranges for six serum enzymes: further statistical analysis and the effects of different treatments of blood specimens. Clin Chim Acta. 1973 Sep 28;48(1):49–63. doi: 10.1016/0009-8981(73)90217-9. [DOI] [PubMed] [Google Scholar]
  10. Thompson M. W., Murphy E. G., McAlpine P. J. An assessment of the creatine kinase test in the detection of carriers of Duchenne muscular dystrophy. J Pediatr. 1967 Jul;71(1):82–93. doi: 10.1016/s0022-3476(67)80235-x. [DOI] [PubMed] [Google Scholar]
  11. WILSON K. M., EVANS K. A., CARTER C. O. CREATINE KINASE LEVELS IN WOMEN WHO CARRY GENES FOR THREE TYPES OF MUSCULAR DYSTROPHY. Br Med J. 1965 Mar 20;1(5437):750–753. doi: 10.1136/bmj.1.5437.750. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Zatz M., Frota-Pessoa O., Levy J. A., Peres C. A. Creatine-phosphokinase (CPK) activity in relatives of patients with X-linked muscular dystrophies: a Brazilian study. J Genet Hum. 1976 Jun;24(2):153–168. [PubMed] [Google Scholar]
  13. Zatz M., Frota-Pessoa O., Peres C. A. Use of normal daughters' CPK levels in the estimation of heterozygosity risks in X-linked muscular dystrophies. Hum Hered. 1975;25(5):354–359. doi: 10.1159/000152746. [DOI] [PubMed] [Google Scholar]

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