Skip to main content
Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1976 Apr;13(2):103–122. doi: 10.1136/jmg.13.2.103

Classification and relationships of induced chromosomal structual changes.

J R Savage
PMCID: PMC1013369  PMID: 933108

Abstract

A detailed survey is given of the types and classification of primary structural changes that can be induced in chromosomes and observed at the first metaphase after the initial damage. Comments upon identification and scoring are given for the benefit of new workers. The annotation concludes with a brief discussion of the potential relationships between the primary types, and the secondary or derived types encountered in clinical studies.

Full text

PDF
104

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Carrano A. V., Heddle J. A. The fate of chromosome aberrations. J Theor Biol. 1973 Feb;38(2):289–304. doi: 10.1016/0022-5193(73)90176-8. [DOI] [PubMed] [Google Scholar]
  2. Cohen M. M., MacGillivray M. H., Capraro V. J., Aceto T. A. Human dicentric Y chromosomes. Case report and review of the literature. J Med Genet. 1973 Mar;10(1):74–79. doi: 10.1136/jmg.10.1.74. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Fox D. P. The effects of x-rays on the chromosomes of locust embryos. 3. The chromatid aberration types. Chromosoma. 1967;20(3):386–412. [PubMed] [Google Scholar]
  4. Gregory W. D., Miller M. W., Carstensen E. L., Cataldo F. L., Reddy M. M. Non-thermal effects of 2 MHz ultrasound on the growth and cytology of Vicia faba roots. Br J Radiol. 1974 Feb;47(554):122–129. doi: 10.1259/0007-1285-47-554-122. [DOI] [PubMed] [Google Scholar]
  5. Henry S., Cohen M. M., Karzon D. T. Cytogenetic effects of measles virus fusion factor (FF) on human leukocytes. Cytogenetics. 1971;10(5):367–376. doi: 10.1159/000130155. [DOI] [PubMed] [Google Scholar]
  6. Johnson R. T., Rao P. N. Mammalian cell fusion: induction of premature chromosome condensation in interphase nuclei. Nature. 1970 May 23;226(5247):717–722. doi: 10.1038/226717a0. [DOI] [PubMed] [Google Scholar]
  7. Kihlman B. A., Hartley B. "Sub-chromatid" exchanges and the "folded fibre" model of chromosome structure. Hereditas. 1967;57(1):289–294. [PubMed] [Google Scholar]
  8. Kistenmacher M. L., Punnett H. H. Comparative behavior of ring chromosomes. Am J Hum Genet. 1970 May;22(3):304–318. [PMC free article] [PubMed] [Google Scholar]
  9. Lovelace R. Chromosome Shattering by Ultraviolet Radiation (2650 A). Proc Natl Acad Sci U S A. 1954 Dec;40(12):1129–1135. doi: 10.1073/pnas.40.12.1129. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Moore C. M., Heller R. H., Thomas G. H. Developmental abnormalities associated with a ring chromosome 6. J Med Genet. 1973 Sep;10(3):299–303. doi: 10.1136/jmg.10.3.299. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. NEARY G. J., EVANS H. J. Chromatid breakage by irradiation and the oxygen effect. Nature. 1958 Sep 27;182(4639):890–891. doi: 10.1038/182890a0. [DOI] [PubMed] [Google Scholar]
  12. Nichols W. W., Levan A., Aula P., Norrby E. Chromosome damage associated with the measles virus in vitro. Hereditas. 1965;54(1):101–118. doi: 10.1111/j.1601-5223.1965.tb02008.x. [DOI] [PubMed] [Google Scholar]
  13. Olivieri G., Rizzoni M., Gatti M., Palitti F. On factors affecting the pattern of rejoining (symmetric or asymmetric) in the formation of chromosomal aberrations. Mutat Res. 1973 Oct;20(1):101–106. doi: 10.1016/0027-5107(73)90102-4. [DOI] [PubMed] [Google Scholar]
  14. REVELL S. H. The accurate estimation of chromatid breakage, and its relevance to a new interpretation of chromatid aberrations induced by ionizing radiations. Proc R Soc Lond B Biol Sci. 1959 Sep 1;150:563–589. doi: 10.1098/rspb.1959.0043. [DOI] [PubMed] [Google Scholar]
  15. Revell S. H. Evidence for a dose-squared term in the dose-response curve for real chromatid discontinuities induced by x-rays, and some theoretical consequences thereof. Mutat Res. 1966 Feb;3(1):34–53. doi: 10.1016/0027-5107(66)90006-6. [DOI] [PubMed] [Google Scholar]
  16. SMITH-WHITE S., PEACOCK W. J., TURNER B., DEN DULK G. M. A ring chromosome in man. Nature. 1963 Jan 5;197:102–103. doi: 10.1038/197102b0. [DOI] [PubMed] [Google Scholar]
  17. Sasaki M. S., Norman A. Selection against chromosome aberrations in human lymphocytes. Nature. 1967 Apr 29;214(5087):502–503. doi: 10.1038/214502a0. [DOI] [PubMed] [Google Scholar]
  18. Savage J. R., Papworth D. G. The effect of variable G2 duration upon the interpretation of yield-time curves of radiation-induced chromatid aberrations. J Theor Biol. 1973 Jan;38(1):17–38. doi: 10.1016/0022-5193(73)90222-1. [DOI] [PubMed] [Google Scholar]
  19. Savage J. R., Preston R. J., Neary G. J. Chromatid aberrations in Tradescantia bracteata and a further test of Revell's hypothesis. Mutat Res. 1968 Jan-Feb;5(1):47–56. doi: 10.1016/0027-5107(68)90080-8. [DOI] [PubMed] [Google Scholar]
  20. Sax K. An Analysis of X-Ray Induced Chromosomal Aberrations in Tradescantia. Genetics. 1940 Jan;25(1):41–68. doi: 10.1093/genetics/25.1.41. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Sax K. Chromosome Aberrations Induced by X-Rays. Genetics. 1938 Sep;23(5):494–516. doi: 10.1093/genetics/23.5.494. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Scheid W., Traut H. Visualization by scanning electron microscopy of achromatic lesions ("gaps") induced by x-rays in chromosomes of Vicia faba. Mutat Res. 1971 Feb;11(2):253–255. [PubMed] [Google Scholar]
  23. Seabright M. High resolution studies on the pattern of induced exchanges in the human karyotype. Chromosoma. 1973;40(4):333–346. doi: 10.1007/BF00399426. [DOI] [PubMed] [Google Scholar]
  24. Sperling K., Rao P. N. Mammalian cell fusion. V. Replication behaviour of heterochromatin as observed by premature chromosome condensation. Chromosoma. 1974 Mar 14;45(2):121–131. doi: 10.1007/BF00362306. [DOI] [PubMed] [Google Scholar]
  25. WILSON G. B., SPARROW A. H. Configurations resulting from iso-chromatid and iso-subchromatid unions after meiotic and mitotic prophase irradiation. Chromosoma. 1960;11:229–244. doi: 10.1007/BF00328653. [DOI] [PubMed] [Google Scholar]
  26. Wolff S. On the "tertiary " structure of chromosomes. Mutat Res. 1970 Nov;10(5):405–414. doi: 10.1016/0027-5107(70)90001-1. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Medical Genetics are provided here courtesy of BMJ Publishing Group

RESOURCES