Abstract
Mutant curly-tail mice are genetically predisposed to produce offspring with neural tube defects. Estimation of alpha-fetoprotein in the amniotic fluid of fetuses of these mutants has shown that the levels are raised in fetuses with exencephaly and open spina bifida. This suggests that these mice are a valid model for studies of the aetiology and genesis of neural tube defects in man.
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Selected References
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- Abelev G. I. Alpha-fetoprotein in ontogenesis and its association with malignant tumors. Adv Cancer Res. 1971;14:295–358. doi: 10.1016/s0065-230x(08)60523-0. [DOI] [PubMed] [Google Scholar]
- Brock D. J., Scrimgeour J. B. Early prenatal diagnosis of anencephaly. Lancet. 1972 Dec 9;2(7789):1252–1253. doi: 10.1016/s0140-6736(72)92306-9. [DOI] [PubMed] [Google Scholar]
- Brock D. J., Sutcliffe R. G. Alpha-fetoprotein in the antenatal diagnosis of anencephaly and spina bifida. Lancet. 1972 Jul 29;2(7770):197–199. doi: 10.1016/s0140-6736(72)91634-0. [DOI] [PubMed] [Google Scholar]
- Gitlin D., Boesman M. Serum alpha-fetoprotein, albumin, and gamma-G-globulin in the human conceptus. J Clin Invest. 1966 Nov;45(11):1826–1838. doi: 10.1172/JCI105486. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gitlin D. Normal biology of alpha-fetoprotein. Ann N Y Acad Sci. 1975 Aug 22;259:7–16. doi: 10.1111/j.1749-6632.1975.tb25397.x. [DOI] [PubMed] [Google Scholar]
- Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
- Seller M. J. Alpha-fetoprotein and the prenatal diagnosis of neural tube defects. Dev Med Child Neurol. 1974 Jun;16(3):369–371. doi: 10.1111/j.1469-8749.1974.tb03350.x. [DOI] [PubMed] [Google Scholar]
- Seller M. J., Campbell S., Coltart T. M., Singer J. D. Early termination of anencephalic pregnancy after detection by raised alpha-fetoprotein levels. Lancet. 1973 Jul 14;2(7820):73–73. doi: 10.1016/s0140-6736(73)93264-9. [DOI] [PubMed] [Google Scholar]
- Wepsic H. T., Sell S. Alpha-fetoprotein: expression in human disease and in rat experimental models. Prog Exp Tumor Res. 1974;19:297–324. doi: 10.1159/000395863. [DOI] [PubMed] [Google Scholar]