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. 1977 Oct;14(5):335–338. doi: 10.1136/jmg.14.5.335

H-Y antigen and the growth of the dominant gonad.

U Mittwoch
PMCID: PMC1013616  PMID: 592349

Abstract

The evolutionary conservation of H-Y antigen and its expression in the heterogametic sex regardless of whether this is male or female must mean that the antigen is associated with a common denominator underlying the development of mammalian testes and avian ovaries. It is suggested that one such common denominator is an enhanced growth rate of the dominant heterogametic gonad at a critical stage of its development.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett D., Mathieson B. J., Scheid M., Yanagisawa K., Boyse E. A., Wachtel S., Cattanach B. M. Serological evidence for H-Y antigen in Sxr, XX sex-reversal phenotypic males. Nature. 1977 Jan 20;265(5591):255–257. doi: 10.1038/265255a0. [DOI] [PubMed] [Google Scholar]
  2. Erickson R. P. Androgen-modified expression compared with Y linkage of male specific antigen. Nature. 1977 Jan 6;265(5589):59–61. doi: 10.1038/265059a0. [DOI] [PubMed] [Google Scholar]
  3. Espiner E. A., Veale A. M., Sands V. E., Fitzgerald P. H. Familial syndrome of streak gonads and normal male karyotype in five phenotypic females. N Engl J Med. 1970 Jul 2;283(1):6–11. doi: 10.1056/NEJM197007022830102. [DOI] [PubMed] [Google Scholar]
  4. Ferguson-Smith M. A. X-Y chromosomal interchange in the aetiology of true hermaphroditism and of XX Klinefelter's syndrome. Lancet. 1966 Aug 27;2(7461):475–476. doi: 10.1016/s0140-6736(66)92778-4. [DOI] [PubMed] [Google Scholar]
  5. Fredga K., Gropp A., Winking H., Frank F. Fertile XX- and XY-type females in the wood lemming Myopus schisticolor. Nature. 1976 May 20;261(5557):225–227. doi: 10.1038/261225a0. [DOI] [PubMed] [Google Scholar]
  6. Gasser D. L., Silvers W. K. Genetics and immunology of sex-linked antigens. Adv Immunol. 1972;15:215–247. doi: 10.1016/s0065-2776(08)60686-0. [DOI] [PubMed] [Google Scholar]
  7. Jean C. Développement volumétrique des gonades du foetus de souris. C R Seances Soc Biol Fil. 1971;165(12):2341–2345. [PubMed] [Google Scholar]
  8. Lyon M. F. X-chromosome inactivation and developmental patterns in mammals. Biol Rev Camb Philos Soc. 1972 Jan;47(1):1–35. doi: 10.1111/j.1469-185x.1972.tb00969.x. [DOI] [PubMed] [Google Scholar]
  9. Mittwoch U., Delhanty J. D., Beck F. Growth of differentiating testes and ovaries. Nature. 1969 Dec 27;224(5226):1323–1325. doi: 10.1038/2241323a0. [DOI] [PubMed] [Google Scholar]
  10. Mittwoch U. Differential growth of human foetal gonads with respect to sex and body side. Ann Hum Genet. 1976 Jul;40(1):133–138. doi: 10.1111/j.1469-1809.1976.tb00171.x. [DOI] [PubMed] [Google Scholar]
  11. Mittwoch U., Narayanan T. L., Delhanty J. D., Smith C. A. Gonadal growth in chick embryos. Nat New Biol. 1971 Jun 16;231(24):197–200. doi: 10.1038/newbio231197a0. [DOI] [PubMed] [Google Scholar]
  12. Mittwoch U. Sex determination in birds and mammals. Nature. 1971 Jun 18;231(5303):432–434. doi: 10.1038/231432a0. [DOI] [PubMed] [Google Scholar]
  13. Morris T. The XO and Oy chromosome constitutions in the mouse. Genet Res. 1968 Oct;12(2):125–137. doi: 10.1017/s0016672300011745. [DOI] [PubMed] [Google Scholar]
  14. Ohno S., Christian L. C., Wachtel S. S., Koo G. C. Hormone-like role of H-Y antigen in bovine freemartin gonad. Nature. 1976 Jun 17;261(5561):597–599. doi: 10.1038/261597a0. [DOI] [PubMed] [Google Scholar]
  15. Short R. V., Smith J., Mann T., Evans E. P., Hallett J., Fryer A., Hamerton J. L. Cytogenetic and endocrine studies of a freemartin heifer and its bull co-twin. Cytogenetics. 1969;8(5):369–388. doi: 10.1159/000130047. [DOI] [PubMed] [Google Scholar]
  16. Wachtel S. S., Koo G. C., Boyse E. A. Evolutionary conservation of H-Y ('male') antigen. Nature. 1975 Mar 20;254(5497):270–272. doi: 10.1038/254270a0. [DOI] [PubMed] [Google Scholar]
  17. Wachtel S. S., Koo G. C., Breg W. R., Thaler H. T., Dillard G. M., Rosenthal I. M., Dosik H., Gerald P. S., Saenger P., New M. Serologic detection of a y-linked gene in xx males and xx true hermaphrodites. N Engl J Med. 1976 Sep 30;295(14):750–754. doi: 10.1056/NEJM197609302951403. [DOI] [PubMed] [Google Scholar]
  18. Wachtel S. S., Koo G. C., Ohno S., Gropp A., Dev V. G., Tantravahi R., Miller D. A., Miller O. J. H-Y antigen and the origin of XY female wood lemmings (Myopus schisticolor). Nature. 1976 Dec 16;264(5587):638–639. doi: 10.1038/264638a0. [DOI] [PubMed] [Google Scholar]
  19. Wachtel S. S., Ono S., Koo G. C., Boyse E. A. Possible role for H--Y antigen in the primary determination of sex. Nature. 1975 Sep 18;257(5523):235–236. doi: 10.1038/257235a0. [DOI] [PubMed] [Google Scholar]

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