Abstract
A modification of Smith's method is described for deriving recurrence risks for multifactorial conditions when parents are related. Using cleft palate as an example, the possible increased risks caused by consanguinity are discussed.
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- Bonaiti-Pellie C., Feingold J., Briard M. L., Frezal J. Risque de récurrence dans quelques malformations congénitales: anencéphalie, spina-bifida, fentes labiale et palatine. Arch Fr Pediatr. 1976 Dec;33(10):973–986. [PubMed] [Google Scholar]
- Bonaiti-Pellié C., Smith C. Risk tables for genetic counselling in some common congenital malformations. J Med Genet. 1974 Dec;11(4):374–377. doi: 10.1136/jmg.11.4.374. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Briard M. L., Bonaiti-Pellie C., Feingold J., Pavy B., Kaplan J., Bois E. Génétique et épidémiologie des fentes labiales et palatines. Ann Chir Plast. 1974;19(2):87–95. [PubMed] [Google Scholar]
- Smith C. Computer programme to estimate recurrence risks for multifactorial familial disease. Br Med J. 1972 Feb 19;1(5798):495–497. doi: 10.1136/bmj.1.5798.495. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smith C. Recurrence risks for multifactorial inheritance. Am J Hum Genet. 1971 Nov;23(6):578–588. [PMC free article] [PubMed] [Google Scholar]