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. 1991 Sep;54(9):775–779. doi: 10.1136/jnnp.54.9.775

Central motor conduction studies in hereditary spastic paraplegia.

W Schady 1, J P Dick 1, A Sheard 1, S Crampton 1
PMCID: PMC1014514  PMID: 1659616

Abstract

Central motor conduction (CMC) studies were carried out in 25 patients with hereditary spastic paraplegia (HSP). Responses evoked in the lower limbs by transcranial magnetic stimulation of the motor cortex were bilaterally absent in 33% of the patients and, when recordable, were delayed in 75% of cases. Responses in the upper limbs were mostly normal except for those from the five members of one family, which were considerably delayed. There was no correlation between CMC parameters and age, duration of disease or upper limb hyperreflexia. CMC time to the tibialis anterior correlated with disability in patients with juvenile-onset HSP. It is concluded that CMC studies are not useful in detecting subclinical lesions in hereditary spastic paraplegia but may be of value in identifying subgroups of the disease.

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Selected References

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  1. Barker A. T., Jalinous R., Freeston I. L. Non-invasive magnetic stimulation of human motor cortex. Lancet. 1985 May 11;1(8437):1106–1107. doi: 10.1016/s0140-6736(85)92413-4. [DOI] [PubMed] [Google Scholar]
  2. Behan W. M., Maia M. Strümpell's familial spastic paraplegia: genetics and neuropathology. J Neurol Neurosurg Psychiatry. 1974 Jan;37(1):8–20. doi: 10.1136/jnnp.37.1.8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Berger A. R., Shahani B. T. Electrophysiologic evaluation of spinal cord motor conduction. Muscle Nerve. 1989 Dec;12(12):976–980. doi: 10.1002/mus.880121205. [DOI] [PubMed] [Google Scholar]
  4. Cavanagh N. P., Eames R. A., Galvin R. J., Brett E. M., Kelly R. E. Hereditary sensory neuropathy with spastic paraplegia. Brain. 1979 Mar;102(1):79–94. doi: 10.1093/brain/102.1.79. [DOI] [PubMed] [Google Scholar]
  5. Claus D., Harding A. E., Hess C. W., Mills K. R., Murray N. M., Thomas P. K. Central motor conduction in degenerative ataxic disorders: a magnetic stimulation study. J Neurol Neurosurg Psychiatry. 1988 Jun;51(6):790–795. doi: 10.1136/jnnp.51.6.790. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Claus D., Waddy H. M., Harding A. E., Murray N. M., Thomas P. K. Hereditary motor and sensory neuropathies and hereditary spastic paraplegia: a magnetic stimulation study. Ann Neurol. 1990 Jul;28(1):43–49. doi: 10.1002/ana.410280109. [DOI] [PubMed] [Google Scholar]
  7. Dimitrijevic M. R., Lenman J. A., Prevec T., Wheatly K. A study of posterior column function in familial spastic paraplegia. J Neurol Neurosurg Psychiatry. 1982 Jan;45(1):46–49. doi: 10.1136/jnnp.45.1.46. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Donofrio P. D., Tandan R., Albers J. W. Plasma exchange in chronic inflammatory demyelinating polyradiculoneuropathy. Muscle Nerve. 1985 May;8(4):321–327. doi: 10.1002/mus.880080409. [DOI] [PubMed] [Google Scholar]
  9. Eisen A., Hoirch M., Fink M., Goya T., Calne D. Noninvasive measurement of central sensory and motor conduction. Neurology. 1985 Apr;35(4):503–509. doi: 10.1212/wnl.35.4.503. [DOI] [PubMed] [Google Scholar]
  10. Eisen A., Shytbel W., Murphy K., Hoirch M. Cortical magnetic stimulation in amyotrophic lateral sclerosis. Muscle Nerve. 1990 Feb;13(2):146–151. doi: 10.1002/mus.880130211. [DOI] [PubMed] [Google Scholar]
  11. Harding A. E. Hereditary "pure" spastic paraplegia: a clinical and genetic study of 22 families. J Neurol Neurosurg Psychiatry. 1981 Oct;44(10):871–883. doi: 10.1136/jnnp.44.10.871. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hess C. W., Mills K. R., Murray N. M. Measurement of central motor conduction in multiple sclerosis by magnetic brain stimulation. Lancet. 1986 Aug 16;2(8503):355–358. doi: 10.1016/s0140-6736(86)90050-4. [DOI] [PubMed] [Google Scholar]
  13. Hess C. W., Mills K. R., Murray N. M., Schriefer T. N. Magnetic brain stimulation: central motor conduction studies in multiple sclerosis. Ann Neurol. 1987 Dec;22(6):744–752. doi: 10.1002/ana.410220611. [DOI] [PubMed] [Google Scholar]
  14. Holmes G. L., Shaywitz B. A. Strumpell's pure familial spastic paraplegia: case study and review of the literature. J Neurol Neurosurg Psychiatry. 1977 Oct;40(10):1003–1008. doi: 10.1136/jnnp.40.10.1003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Ingram D. A., Swash M. Central motor conduction is abnormal in motor neuron disease. J Neurol Neurosurg Psychiatry. 1987 Feb;50(2):159–166. doi: 10.1136/jnnp.50.2.159. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Ingram D. A., Thompson A. J., Swash M. Central motor conduction in multiple sclerosis: evaluation of abnormalities revealed by transcutaneous magnetic stimulation of the brain. J Neurol Neurosurg Psychiatry. 1988 Apr;51(4):487–494. doi: 10.1136/jnnp.51.4.487. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Kimura J. F-wave velocity in the central segment of the median and ulnar nerves. A study in normal subjects and in patients with Charcot-Marie-Tooth disease. Neurology. 1974 Jun;24(6):539–546. doi: 10.1212/wnl.24.6.539. [DOI] [PubMed] [Google Scholar]
  18. Merton P. A., Morton H. B. Stimulation of the cerebral cortex in the intact human subject. Nature. 1980 May 22;285(5762):227–227. doi: 10.1038/285227a0. [DOI] [PubMed] [Google Scholar]
  19. Mills K. R., Murray N. M. Electrical stimulation over the human vertebral column: which neural elements are excited? Electroencephalogr Clin Neurophysiol. 1986 Jun;63(6):582–589. doi: 10.1016/0013-4694(86)90145-8. [DOI] [PubMed] [Google Scholar]
  20. Pedersen L., Trojaborg W. Visual, auditory and somatosensory pathway involvement in hereditary cerebellar ataxia, Friedreich's ataxia and familial spastic paraplegia. Electroencephalogr Clin Neurophysiol. 1981 Oct;52(4):283–297. doi: 10.1016/0013-4694(81)90057-2. [DOI] [PubMed] [Google Scholar]
  21. SCHWARZ G. A., LIU C. N. Hereditary (familial) spastic paraplegia; further clinical and pathologic observations. AMA Arch Neurol Psychiatry. 1956 Feb;75(2):144–162. doi: 10.1001/archneurpsyc.1956.02330200038005. [DOI] [PubMed] [Google Scholar]
  22. Schady W., Sheard A. A quantitative study of sensory function in hereditary spastic paraplegia. Brain. 1990 Jun;113(Pt 3):709–720. doi: 10.1093/brain/113.3.709. [DOI] [PubMed] [Google Scholar]
  23. Thomas P. K., Jefferys J. G., Smith I. S., Loulakakis D. Spinal somatosensory evoked potentials in hereditary spastic paraplegia. J Neurol Neurosurg Psychiatry. 1981 Mar;44(3):243–246. doi: 10.1136/jnnp.44.3.243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Thompson P. D., Day B. L., Rothwell J. C., Dick J. P., Cowan J. M., Asselman P., Griffin G. B., Sheehy M. P., Marsden C. D. The interpretation of electromyographic responses to electrical stimulation of the motor cortex in diseases of the upper motor neurone. J Neurol Sci. 1987 Aug;80(1):91–110. doi: 10.1016/0022-510x(87)90224-3. [DOI] [PubMed] [Google Scholar]
  25. Thompson P. D., Dick J. P., Asselman P., Griffin G. B., Day B. L., Rothwell J. C., Sheehy M. P., Marsden C. D. Examination of motor function in lesions of the spinal cord by stimulation of the motor cortex. Ann Neurol. 1987 Apr;21(4):389–396. doi: 10.1002/ana.410210412. [DOI] [PubMed] [Google Scholar]
  26. Ugawa Y., Rothwell J. C., Day B. L., Thompson P. D., Marsden C. D. Magnetic stimulation over the spinal enlargements. J Neurol Neurosurg Psychiatry. 1989 Sep;52(9):1025–1032. doi: 10.1136/jnnp.52.9.1025. [DOI] [PMC free article] [PubMed] [Google Scholar]

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