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. 1991 Nov;54(11):989–992. doi: 10.1136/jnnp.54.11.989

Whipple's disease confined to the CNS presenting with multiple intracerebral mass lesions.

S J Wroe 1, M Pires 1, B Harding 1, B D Youl 1, S Shorvon 1
PMCID: PMC1014622  PMID: 1724783

Abstract

A patient with isolated cerebral Whipple's disease presented with signs of raised intracranial pressure and multiple ring enhancing intracerebral mass lesions evident on CT and MRI imaging. Characteristic intracellular bacilliform inclusions were identified in a brain biopsy. Clinical improvement followed treatment with parenteral antibiotics for two weeks and long term sulphamethoxazole-trimethoprim. As CNS relapse of Whipple's disease may occur after several years, long term treatment should include antibiotics that are able to cross the blood-brain barrier.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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