Skip to main content
PMC home page
Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1988 Mar;25(3):191–194. doi: 10.1136/jmg.25.3.191

Absence of close linkage between benign hereditary chorea and the locus D4S10 (probe G8).

O W Quarrell 1, S Youngman 1, M Sarfarazi 1, P S Harper 1
PMCID: PMC1015485  PMID: 2895189

Abstract

A genetic linkage study between benign hereditary chorea and the locus D4S10 using the DNA probe G8 has shown two recombinations in five small families. There were negative lod scores at recombination fractions that show conclusive evidence of linkage in 16 larger British Huntington's disease families. We suggest that although benign hereditary chorea and Huntington's disease may have some clinical similarities they are probably at two different loci.

Full text

PDF
193

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Burns J., Neuhäuser G., Tomasi L. Benign hereditary non-progressive chorea of early onset. Clinical genetics of the syndrome and report of a new family. Neuropadiatrie. 1976 Nov;7(4):431–438. doi: 10.1055/s-0028-1091643. [DOI] [PubMed] [Google Scholar]
  2. Folstein S. E., Phillips J. A., 3rd, Meyers D. A., Chase G. A., Abbott M. H., Franz M. L., Waber P. G., Kazazian H. H., Jr, Conneally P. M., Hobbs W. Huntington's disease: two families with differing clinical features show linkage to the G8 probe. Science. 1985 Aug 23;229(4715):776–779. doi: 10.1126/science.2992086. [DOI] [PubMed] [Google Scholar]
  3. Gusella J. F., Tanzi R. E., Bader P. I., Phelan M. C., Stevenson R., Hayden M. R., Hofman K. J., Faryniarz A. G., Gibbons K. Deletion of Huntington's disease-linked G8 (D4S10) locus in Wolf-Hirschhorn syndrome. Nature. 1985 Nov 7;318(6041):75–78. doi: 10.1038/318075a0. [DOI] [PubMed] [Google Scholar]
  4. Gusella J. F., Wexler N. S., Conneally P. M., Naylor S. L., Anderson M. A., Tanzi R. E., Watkins P. C., Ottina K., Wallace M. R., Sakaguchi A. Y. A polymorphic DNA marker genetically linked to Huntington's disease. Nature. 1983 Nov 17;306(5940):234–238. doi: 10.1038/306234a0. [DOI] [PubMed] [Google Scholar]
  5. Harper P. S., Youngman S., Anderson M. A., Sarfarazi M., Quarrell O., Tanzi R., Shaw D., Wallace P., Conneally P. M., Gusella J. F. Genetic linkage between Huntington's disease and the DNA polymorphism G8 in South Wales families. J Med Genet. 1985 Dec;22(6):447–450. doi: 10.1136/jmg.22.6.447. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kingston H. M., Sarfarazi M., Thomas N. S., Harper P. S. Localisation of the Becker muscular dystrophy gene on the short arm of the X chromosome by linkage to cloned DNA sequences. Hum Genet. 1984;67(1):6–17. doi: 10.1007/BF00270551. [DOI] [PubMed] [Google Scholar]
  7. Kunkel L. M., Smith K. D., Boyer S. H., Borgaonkar D. S., Wachtel S. S., Miller O. J., Breg W. R., Jones H. W., Jr, Rary J. M. Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants. Proc Natl Acad Sci U S A. 1977 Mar;74(3):1245–1249. doi: 10.1073/pnas.74.3.1245. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lathrop G. M., Lalouel J. M., Julier C., Ott J. Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci U S A. 1984 Jun;81(11):3443–3446. doi: 10.1073/pnas.81.11.3443. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Leli D. A., Furlow T. W., Jr, Falgout J. C. Benign familial chorea: an association with intellectual impairment. J Neurol Neurosurg Psychiatry. 1984 May;47(5):471–474. doi: 10.1136/jnnp.47.5.471. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Pincus J. H., Chutorian A. Familial benign chorea with intention tremor: a clinical entity. J Pediatr. 1967 May;70(5):724–729. doi: 10.1016/s0022-3476(67)80322-6. [DOI] [PubMed] [Google Scholar]
  11. Robinson R. O., Thornett C. E. Benign hereditary chorea--response to steroids. Dev Med Child Neurol. 1985 Dec;27(6):814–816. doi: 10.1111/j.1469-8749.1985.tb03807.x. [DOI] [PubMed] [Google Scholar]
  12. Sleigh G., Lindenbaum R. H. Benign (non-paroxysmal) familial chorea. Paediatric perspectives. Arch Dis Child. 1981 Aug;56(8):616–621. doi: 10.1136/adc.56.8.616. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Youngman S., Sarfarazi M., Quarrell O. W., Conneally P. M., Gibbons K., Harper P. S., Shaw D. J., Tanzi R. E., Wallace M. R., Gusella J. F. Studies of a DNA marker (G8) genetically linked to Huntington disease in British families. Hum Genet. 1986 Aug;73(4):333–339. doi: 10.1007/BF00279096. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Medical Genetics are provided here courtesy of BMJ Publishing Group

RESOURCES