Skip to main content
PMC home page
Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1992 Apr;29(4):236–238. doi: 10.1136/jmg.29.4.236

Confirmation of genetic linkage between atopic IgE responses and chromosome 11q13.

R P Young 1, P A Sharp 1, J R Lynch 1, J A Faux 1, G M Lathrop 1, W O Cookson 1, J M Hopkin 1
PMCID: PMC1015920  PMID: 1583642

Abstract

Genetic linkage between atopic IgE responses and chromosome 11q13 (D11S97) has been previously reported in a limited number of extended families. Difficulties of phenotyping in the older family members, poor family structure in some families, and genetic heterogeneity were proposed as possible explanations for the variability in lod scores. To test this finding a second linkage study of 64 young nuclear families was undertaken and gave a two point lod score of 3.8 at theta = 0.07 (assuming theta m = theta f). A test of genetic heterogeneity in the nuclear families shows that atopic IgE responses are linked to this locus in 60 to 100% of families (approximate 95% confidence limits).

Full text

PDF
237

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blumenthal M. N., Namboodiri K., Mendell N., Gleich G., Elston R. C., Yunis E. Genetic transmission of serum IgE Levels. Am J Med Genet. 1981;10(3):219–228. doi: 10.1002/ajmg.1320100304. [DOI] [PubMed] [Google Scholar]
  2. Borecki I. B., Rao D. C., Lalouel J. M., McGue M., Gerrard J. W. Demonstration of a common major gene with pleiotropic effects on immunoglobulin E levels and allergy. Genet Epidemiol. 1985;2(4):327–338. doi: 10.1002/gepi.1370020402. [DOI] [PubMed] [Google Scholar]
  3. Cookson W. O., Hopkin J. M. Dominant inheritance of atopic immunoglobulin-E responsiveness. Lancet. 1988 Jan 16;1(8577):86–88. doi: 10.1016/s0140-6736(88)90286-3. [DOI] [PubMed] [Google Scholar]
  4. Cookson W. O., Sharp P. A., Faux J. A., Hopkin J. M. Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q. Lancet. 1989 Jun 10;1(8650):1292–1295. doi: 10.1016/s0140-6736(89)92687-1. [DOI] [PubMed] [Google Scholar]
  5. Gerrard J. W., Rao D. C., Morton N. E. A genetic study of immunoglobulin E. Am J Hum Genet. 1978 Jan;30(1):46–58. [PMC free article] [PubMed] [Google Scholar]
  6. Gurling H. Genetic linkage and psychiatric disease. Nature. 1990 Mar 22;344(6264):298–299. doi: 10.1038/344298a0. [DOI] [PubMed] [Google Scholar]
  7. Holford-Strevens V., Warren P., Wong C., Manfreda J. Serum total immunoglobulin E levels in Canadian adults. J Allergy Clin Immunol. 1984 Apr;73(4):516–522. doi: 10.1016/0091-6749(84)90363-4. [DOI] [PubMed] [Google Scholar]
  8. Kjellman N. I. Predictive value of high IgE levels in children. Acta Paediatr Scand. 1976 Jul;65(4):465–471. doi: 10.1111/j.1651-2227.1976.tb04915.x. [DOI] [PubMed] [Google Scholar]
  9. Kjellman N. M., Johansson S. G., Roth A. Serum IgE levels in healthy children quantified by a sandwich technique (PRIST). Clin Allergy. 1976 Jan;6(1):51–59. doi: 10.1111/j.1365-2222.1976.tb01411.x. [DOI] [PubMed] [Google Scholar]
  10. Marsh D. G., Bias W. B., Ishizaka K. Genetic control of basal serum immunoglobulin E level and its effect on specific reaginic sensitivity. Proc Natl Acad Sci U S A. 1974 Sep;71(9):3588–3592. doi: 10.1073/pnas.71.9.3588. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Marsh D. G., Bias W. B., Ishizaka K. Genetic control of basal serum immunoglobulin E level and its effect on specific reaginic sensitivity. Proc Natl Acad Sci U S A. 1974 Sep;71(9):3588–3592. doi: 10.1073/pnas.71.9.3588. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Marsh D. G., Zwollo P., Huang S. K., Ansari A. A. Molecular genetics of human immune responsiveness to allergens. Ciba Found Symp. 1989;147:171–187. doi: 10.1002/9780470513866.ch11. [DOI] [PubMed] [Google Scholar]
  13. Peat J. K., Britton W. J., Salome C. M., Woolcock A. J. Bronchial hyperresponsiveness in two populations of Australian schoolchildren. II. Relative importance of associated factors. Clin Allergy. 1987 Jul;17(4):283–290. doi: 10.1111/j.1365-2222.1987.tb02016.x. [DOI] [PubMed] [Google Scholar]
  14. SMITH C. A. TESTING FOR HETEROGENEITY OF RECOMBINATION FRACTION VALUES IN HUMAN GENETICS. Ann Hum Genet. 1963 Nov;27:175–182. doi: 10.1111/j.1469-1809.1963.tb00210.x. [DOI] [PubMed] [Google Scholar]
  15. Sears M. R., Herbison G. P., Holdaway M. D., Hewitt C. J., Flannery E. M., Silva P. A. The relative risks of sensitivity to grass pollen, house dust mite and cat dander in the development of childhood asthma. Clin Exp Allergy. 1989 Jul;19(4):419–424. doi: 10.1111/j.1365-2222.1989.tb02408.x. [DOI] [PubMed] [Google Scholar]
  16. Wittig H. J., Belloit J., De Fillippi I., Royal G. Age-related serum immunoglobulin E levels in healthy subjects and in patients with allergic disease. J Allergy Clin Immunol. 1980 Oct;66(4):305–313. doi: 10.1016/0091-6749(80)90026-3. [DOI] [PubMed] [Google Scholar]
  17. Zetterström O., Johansson S. G. IgE concentrations measured by PRIST in serum of healthy adults and in patients with respiratory allergy. A diagnostic approach. Allergy. 1981 Nov;36(8):537–547. doi: 10.1111/j.1398-9995.1981.tb01871.x. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Medical Genetics are provided here courtesy of BMJ Publishing Group

RESOURCES