Abstract
An epidemiological and genetic study of profound deafness has been undertaken in the governorate of Nabeul in Tunisia. This paper deals with sensorineural deafness with no associated abnormalities. The prevalence was estimated to be 0.0007 and four clusters could be identified, two of which represent 51% and 34% respectively of the total number of cases. Segregation analysis performed in 29 pedigrees containing 415 subjects with 129 affected cases provided evidence for simple recessive inheritance with no sporadic cases.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BARRAI I., MI M. P., MORTON N. E., YASUDA N. ESTIMATION OF PREVALENCE UNDER INCOMPLETE SELECTION. Am J Hum Genet. 1965 May;17:221–236. [PMC free article] [PubMed] [Google Scholar]
- Bois E., Bonaïti C., Lallemant M., Moatti L., Feingold N., Mayer F. M., Feingold J. Studies on an isolated West Indies population. III. Epidemiologic study of sensorineural hearing loss. Neuroepidemiology. 1987;6(3):139–149. doi: 10.1159/000110109. [DOI] [PubMed] [Google Scholar]
- Bonaïti C., Demenais F., Bois E., Hochez J. Studies on an isolated West Indies population: IV. Genetic study of hearing loss. Genet Epidemiol. 1986;3(2):113–119. doi: 10.1002/gepi.1370030206. [DOI] [PubMed] [Google Scholar]
- Lalouel J. M., Rao D. C., Morton N. E., Elston R. C. A unified model for complex segregation analysis. Am J Hum Genet. 1983 Sep;35(5):816–826. [PMC free article] [PubMed] [Google Scholar]
- MORTON N. E. Genetic tests under incomplete ascertainment. Am J Hum Genet. 1959 Mar;11(1):1–16. [PMC free article] [PubMed] [Google Scholar]
- MORTON N. E. Segregation analysis in human genetics. Science. 1958 Jan 10;127(3289):79–80. doi: 10.1126/science.127.3289.79. [DOI] [PubMed] [Google Scholar]