Skip to main content
PMC home page
Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1990 Sep;27(9):571–576. doi: 10.1136/jmg.27.9.571

Sotos syndrome.

T R Cole 1, H E Hughes 1
PMCID: PMC1017220  PMID: 2231650

Full text

PDF
574

Images in this article

572Image
on p.572
572Image
on p.572
573Image
on p.573

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abraham J. M., Snodgrass G. J. Sotos' syndrome of cerebral gigantism. Arch Dis Child. 1969 Apr;44(234):203–210. doi: 10.1136/adc.44.234.203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bale A. E., Drum M. A., Parry D. M., Mulvihill J. J. Familial Sotos syndrome (cerebral gigantism): craniofacial and psychological characteristics. Am J Med Genet. 1985 Apr;20(4):613–624. doi: 10.1002/ajmg.1320200407. [DOI] [PubMed] [Google Scholar]
  3. Barth P. G., Vlasveld L., Valk J. Unilateral delayed opercularization in a case of Sotos' syndrome (Cerebral Gigantism). Neuroradiology. 1980 Aug;20(1):49–52. doi: 10.1007/BF00346862. [DOI] [PubMed] [Google Scholar]
  4. Beemer F. A., Veenema H., de Pater J. M. Cerebral gigantism (Sotos syndrome) in two patients with fra(X) chromosomes. Am J Med Genet. 1986 Jan-Feb;23(1-2):221–226. doi: 10.1002/ajmg.1320230117. [DOI] [PubMed] [Google Scholar]
  5. Bejar R. L., Smith G. F., Park S., Spellacy W. N., Wolfson S. L., Nyhan W. L. Cerebral gigantism: concentrations of amino acids in plasma and muscle. J Pediatr. 1970 Jan;76(1):105–111. doi: 10.1016/s0022-3476(70)80138-x. [DOI] [PubMed] [Google Scholar]
  6. Bloom A. S., Reese A., Hersh J. H., Podruch P. E., Weisskopf B., Dinno N. Cognition in cerebral gigantism: are the estimates of mental retardation too high? J Dev Behav Pediatr. 1983 Dec;4(4):250–252. [PubMed] [Google Scholar]
  7. Bonvini E., Valente G. Gigantismo cerebrale. Descrizione di un caso. Minerva Pediatr. 1976 Aug 18;28(26):1643–1649. [PubMed] [Google Scholar]
  8. Butler M. G., Dijkstra P. F., Meaney F. J., Gale D. D. Metacarpophalangeal pattern profile analysis in Sotos syndrome: a follow-up report on 34 subjects. Am J Med Genet. 1988 Jan;29(1):143–147. doi: 10.1002/ajmg.1320290118. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Butler M. G., Meaney F. J., Kittur S., Hersh J. H., Hornstein L. Metacarpophalangeal pattern profile analysis in Sotos syndrome. Am J Med Genet. 1985 Apr;20(4):625–629. doi: 10.1002/ajmg.1320200408. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Cramer H., Niederdellmann H. Cerebral gigantism associated with jaw cyst basal cell naevoid syndrome in two families. Arch Psychiatr Nervenkr (1970) 1983;233(2):111–124. doi: 10.1007/BF00343432. [DOI] [PubMed] [Google Scholar]
  11. Dijkstra P. F. Cerebral gigantism (Sotos' syndrome). Metacarpophalangeal pattern profiles. Rofo. 1985 Aug;143(2):183–185. doi: 10.1055/s-2008-1052786. [DOI] [PubMed] [Google Scholar]
  12. Ferrier P. E., de Meuron G., Korol S., Hauser H. Cerebral gigantism (Sotos syndrome) with juvenile macular degeneration. Helv Paediatr Acta. 1980 Mar;35(1):97–102. [PubMed] [Google Scholar]
  13. Fryns J. P. The fragile X syndrome. A study of 83 families. Clin Genet. 1984 Dec;26(6):497–528. doi: 10.1111/j.1399-0004.1984.tb01099.x. [DOI] [PubMed] [Google Scholar]
  14. Gemelli M., Carlo Stella N., Barberio G., Tortorella G., Mamì C., De Luca F. Sindrome di Sotos in due fratelli. Conferma di una ereditarietà autosomica recessiva? Minerva Pediatr. 1982 Nov 30;34(22):983–986. [PubMed] [Google Scholar]
  15. Ginter D. N., Scott C. I. Cerebral gigantism. Birth Defects Orig Artic Ser. 1975;11(2):415–422. [PubMed] [Google Scholar]
  16. Goldstein D. J., Ward R. E., Moore E., Fremion A. S., Wappner R. S. Overgrowth, congenital hypotonia, nystagmus, strabismus, and mental retardation: variant of dominantly inherited Sotos sequence? Am J Med Genet. 1988 Apr;29(4):783–792. doi: 10.1002/ajmg.1320290408. [DOI] [PubMed] [Google Scholar]
  17. Goumy P., Malpuech G., Gannat M., Menut G. Gigantisme cérébral familial. Une nouvelle observation à transmission autosomique dominante? Pediatrie. 1979 Apr-May;34(3):249–256. [PubMed] [Google Scholar]
  18. Hansen F. J., Friis B. Familial occurrence of cerebral gigantism, Sotos' syndrome. Acta Paediatr Scand. 1976 May;65(3):387–389. doi: 10.1111/j.1651-2227.1976.tb04902.x. [DOI] [PubMed] [Google Scholar]
  19. Hulse J. A. Two children with cerebral gigantism and congenital primary hypothyroidism. Dev Med Child Neurol. 1981 Apr;23(2):242–246. doi: 10.1111/j.1469-8749.1981.tb02448.x. [DOI] [PubMed] [Google Scholar]
  20. Kaneko H., Tsukahara M., Tachibana H., Kurashige H., Kuwano A., Kajii T. Congenital heart defects in Sotos sequence. Am J Med Genet. 1987 Mar;26(3):569–576. doi: 10.1002/ajmg.1320260310. [DOI] [PubMed] [Google Scholar]
  21. Livieri C., Gelmi C. G., Lorini R., Gasparoni A. Retinal degeneration in Sotos' syndrome. Helv Paediatr Acta. 1982;37(1):93–94. [PubMed] [Google Scholar]
  22. Livingood A. B., Borengasser M. A. Cerebral gigantism in infancy: implications for psychological and social development. Child Psychiatry Hum Dev. 1981 Fall;12(1):46–53. doi: 10.1007/BF00706673. [DOI] [PubMed] [Google Scholar]
  23. Mace J. W., Gotlin R. W. Cerebral gigantism. Triad of findings helpful in diagnosis. Clin Pediatr (Phila) 1970 Nov;9(11):662–667. doi: 10.1177/000992287000901112. [DOI] [PubMed] [Google Scholar]
  24. Magilavy D. B., Petty R. E., Cassidy J. T., Sullivan D. B. A syndrome of childhood polyarteritis. J Pediatr. 1977 Jul;91(1):25–30. doi: 10.1016/s0022-3476(77)80437-x. [DOI] [PubMed] [Google Scholar]
  25. Maldonado V., Gaynon P. S., Poznanski A. K. Cerebral gigantism associated with Wilms' tumor. Am J Dis Child. 1984 May;138(5):486–488. doi: 10.1001/archpedi.1984.02140430062016. [DOI] [PubMed] [Google Scholar]
  26. McNicholl B. Excessive head growth in early infancy: a feature of Sotos' syndrome. Ir Med J. 1987 Sep;80(9):261–262. [PubMed] [Google Scholar]
  27. Milunsky A., Cowie V. A., Donoghue E. C. Cerebral gigantism in childhood. A report of two cases and a review of the literature. Pediatrics. 1967 Sep;40(3):395–402. [PubMed] [Google Scholar]
  28. Moriyama M., Terashima K., Fukushima Y., Kuroki Y. [Urogenital anomalies in patients with Sotos syndrome]. Nihon Hinyokika Gakkai Zasshi. 1984 Apr;75(4):591–593. doi: 10.5980/jpnjurol1928.75.4_591. [DOI] [PubMed] [Google Scholar]
  29. Motohashi N., Pruzansky S., Kawata T. Roentgencephalometric analysis of cerebral gigantism: report of four patients. J Craniofac Genet Dev Biol. 1981;1(1):73–94. [PubMed] [Google Scholar]
  30. Nevo S., Zeltzer M., Benderly A., Levy J. Evidence for autosomal recessive inheritance in cerebral gigantism. J Med Genet. 1974 Jun;11(2):158–165. doi: 10.1136/jmg.11.2.158. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Poznanski A. K., Stephenson J. M. Radiographic findings in hypothalamic acceleration of growth associated with cerebral atrophy and mental retardation (cerebral gigantism). Radiology. 1967 Mar;88(3):446–456. doi: 10.1148/88.3.446. [DOI] [PubMed] [Google Scholar]
  32. SOTOS J. F., DODGE P. R., MUIRHEAD D., CRAWFORD J. D., TALBOT N. B. CEREBRAL GIGANTISM IN CHILDHOOD. A SYNDROME OF EXCESSIVELY RAPID GROWTH AND ACROMEGALIC FEATURES AND A NONPROGRESSIVE NEUROLOGIC DISORDER. N Engl J Med. 1964 Jul 16;271:109–116. doi: 10.1056/NEJM196407162710301. [DOI] [PubMed] [Google Scholar]
  33. Smith A., Farrar J. R., Silink M., Judzewitsch R. Dominant Sotos's syndrome. Arch Dis Child. 1980 Jul;55(7):579–579. doi: 10.1136/adc.55.7.579. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Sotos J. F., Cutler E. A., Dodre P. Cerebral gigantism. Am J Dis Child. 1977 Jun;131(6):625–627. doi: 10.1001/archpedi.1977.02120190019001. [DOI] [PubMed] [Google Scholar]
  35. Sotos J. F., Romshe C. A., Cutler E. A. Cerebral gigantism and primary hypothyroidism: pleiotropy or incidental concurrence. Am J Med Genet. 1978;2(2):201–205. doi: 10.1002/ajmg.1320020211. [DOI] [PubMed] [Google Scholar]
  36. Sugarman G. I., Heuser E. T., Reed W. B. A case of cerebral gigantism and hepatocarcinoma. Am J Dis Child. 1977 Jun;131(6):631–633. doi: 10.1001/archpedi.1977.02120190025004. [DOI] [PubMed] [Google Scholar]
  37. Turner G., Daniel A., Frost M. X-linked mental retardation, macro-orchidism, and the Xq27 fragile site. J Pediatr. 1980 May;96(5):837–841. doi: 10.1016/s0022-3476(80)80552-x. [DOI] [PubMed] [Google Scholar]
  38. Wilson T. A., Neufeld M. R., Robinow M., Johanson A. J. Cerebral gigantism and thyrotoxicosis. J Pediatr. 1980 Apr;96(4):685–687. doi: 10.1016/s0022-3476(80)80741-4. [DOI] [PubMed] [Google Scholar]
  39. Winship I. M. Sotos syndrome--autosomal dominant inheritance substantiated. Clin Genet. 1985 Sep;28(3):243–246. doi: 10.1111/j.1399-0004.1985.tb00393.x. [DOI] [PubMed] [Google Scholar]
  40. Wisniewski L. P., Witt M. E., Ginsberg-Fellner F., Wilner J., Desnick R. J. Prader-Willi syndrome and a bisatellited derivative of chromosome 15. Clin Genet. 1980 Jul;18(1):42–47. doi: 10.1111/j.1399-0004.1980.tb01363.x. [DOI] [PubMed] [Google Scholar]
  41. Wit J. M., Beemer F. A., Barth P. G., Oorthuys J. W., Dijkstra P. F., Van den Brande J. L., Leschot N. J. Cerebral gigantism (Sotos syndrome). Compiled data of 22 cases. Analysis of clinical features, growth and plasma somatomedin. Eur J Pediatr. 1985 Jul;144(2):131–140. doi: 10.1007/BF00451898. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Medical Genetics are provided here courtesy of BMJ Publishing Group

RESOURCES