Skip to main content
PMC home page
Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1989 Apr;26(4):267–271. doi: 10.1136/jmg.26.4.267

Consanguinity related prenatal and postnatal mortality of the populations of seven Pakistani Punjab cities.

S A Shami 1, L H Schmitt 1, A H Bittles 1
PMCID: PMC1017301  PMID: 2716036

Abstract

A retrospective study was conducted on prenatal and postnatal mortality among the populations of seven cities in the Pakistani province of Punjab. Consanguineous marriages were strongly favoured and the coefficients of inbreeding (F) for the present generation in each locality ranged from 0.0236 to 0.0286. There was a highly significant relationship between the degree of inbreeding and mortality, with most consanguinity related deaths reported in the neonatal, infantile, and childhood periods. The findings strongly suggest that consanguinity may play a major role in the high rates of postnatal mortality observed in Pakistani communities now resident in the United Kingdom.

Full text

PDF
268

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahmed A. H. Consanguinity and schizophrenia in Sudan. Br J Psychiatry. 1979 Jun;134:635–636. doi: 10.1192/bjp.134.6.635. [DOI] [PubMed] [Google Scholar]
  2. Al-Awadi S. A., Naguib K. K., Moussa M. A., Farag T. I., Teebi A. S., el-Khalifa M. Y. The effect of consanguineous marriages on reproductive wastage. Clin Genet. 1986 May;29(5):384–388. doi: 10.1111/j.1399-0004.1986.tb00509.x. [DOI] [PubMed] [Google Scholar]
  3. Alfi O. S., Chang R., Azen S. P. Evidence for genetic control of nondisjunction in man. Am J Hum Genet. 1980 Jul;32(4):477–483. [PMC free article] [PubMed] [Google Scholar]
  4. Basu S. K. Effect of consanguinity among North India Muslims. J Popul Res. 1975 Jan-Jun;2(1):57–68. [PubMed] [Google Scholar]
  5. Darr A., Modell B. The frequency of consanguineous marriage among British Pakistanis. J Med Genet. 1988 Mar;25(3):186–190. doi: 10.1136/jmg.25.3.186. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Devi A. R., Rao N. A., Bittles A. H. Inbreeding and the incidence of childhood genetic disorders in Karnataka, South India. J Med Genet. 1987 Jun;24(6):362–365. doi: 10.1136/jmg.24.6.362. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gatrad A. R., Read A. P., Watson G. H. Consanguinity and complex cardiac anomalies with situs ambiguus. Arch Dis Child. 1984 Mar;59(3):242–245. doi: 10.1136/adc.59.3.242. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gillies D. R., Lealman G. T., Lumb K. M., Congdon P. Analysis of ethnic influence on stillbirths and infant mortality in Bradford 1975-81. J Epidemiol Community Health. 1984 Sep;38(3):214–217. doi: 10.1136/jech.38.3.214. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Habib Z., Bök J. A. Consanguinity and incidence of thalassaemia in Egypt. Hereditas. 1983;99(2):215–217. doi: 10.1111/j.1601-5223.1983.tb00894.x. [DOI] [PubMed] [Google Scholar]
  10. Hafez M., El-Tahan H., Awadalla M., El-Khayat H., Abdel-Gafar A., Ghoneim M. Consanguineous matings in the Egyptian population. J Med Genet. 1983 Feb;20(1):58–60. doi: 10.1136/jmg.20.1.58. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hann K. L. Inbreeding and fertility in a South Indian population. Ann Hum Biol. 1985 May-Jun;12(3):267–274. doi: 10.1080/03014468500007771. [DOI] [PubMed] [Google Scholar]
  12. Honeyman M. M., Bahl L., Marshall T., Wharton B. A. Consanguinity and fetal growth in Pakistani Moslems. Arch Dis Child. 1987 Mar;62(3):231–235. doi: 10.1136/adc.62.3.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Imaizumi Y. A recent survey of consanguineous marriages in Japan. Clin Genet. 1986 Sep;30(3):230–233. doi: 10.1111/j.1399-0004.1986.tb00600.x. [DOI] [PubMed] [Google Scholar]
  14. Imaizumi Y., Shinozaki N., Aoki A. Inbreeding in Japan: Results of a nation-wide study. Jinrui Idengaku Zasshi. 1975 Sep;20(2):91–107. [PubMed] [Google Scholar]
  15. Lumb K. M., Congdon P. J., Lealman G. T. A comparative review of Asian and British-born maternity patients in Bradford, 1974-8. J Epidemiol Community Health. 1981 Jun;35(2):106–109. doi: 10.1136/jech.35.2.106. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Makov E., Bittles A. H. On the choice of mathematical models for the estimation of lethal gene equivalents in man. Heredity (Edinb) 1986 Dec;57(Pt 3):377–380. doi: 10.1038/hdy.1986.136. [DOI] [PubMed] [Google Scholar]
  17. Morton N. E., Crow J. F., Muller H. J. AN ESTIMATE OF THE MUTATIONAL DAMAGE IN MAN FROM DATA ON CONSANGUINEOUS MARRIAGES. Proc Natl Acad Sci U S A. 1956 Nov;42(11):855–863. doi: 10.1073/pnas.42.11.855. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Naderi S. Congenital abnormalities in newborns of consanguineous and nonconsanguineous parents. Obstet Gynecol. 1979 Feb;53(2):195–199. [PubMed] [Google Scholar]
  19. Rao P. S., Inbaraj S. G. Inbreeding effects on fertility and sterility in southern India. J Med Genet. 1979 Feb;16(1):24–31. doi: 10.1136/jmg.16.1.24. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Rao P. S., Inbaraj S. G. Trends in human reproductive wastage in relation to long-term practice of inbreeding. Ann Hum Genet. 1979 Jan;42(3):401–413. doi: 10.1111/j.1469-1809.1979.tb00672.x. [DOI] [PubMed] [Google Scholar]
  21. Rao P. S. Religion and intensity of inbreeding in Tamil Nadu, South India. Soc Biol. 1983 Winter;30(4):413–422. doi: 10.1080/19485565.1983.9988554. [DOI] [PubMed] [Google Scholar]
  22. SCHULL W. J., YANASE T., NEMOTO H. Kuroshima: the impact of religion on an island's genetic heritage. Hum Biol. 1962 Dec;34:271–298. [PubMed] [Google Scholar]
  23. Schull W. J., Neel J. V. The effects of parental consanguinity and inbreeding in Hirado, Japan. V. Summary and interpretation. Am J Hum Genet. 1972 Jul;24(4):425–453. [PMC free article] [PubMed] [Google Scholar]
  24. Shami S. A., Iqbal I. Consanguineous marriages in the population of Sheikhupura (Punjab), Pakistan. Biologia. 1983;29(2):231–244. [PubMed] [Google Scholar]
  25. Yamaguchi M., Yanase T., Nagano H., Nakamoto N. Effects of inbreeding on mortlaity in Fukuoka population. Am J Hum Genet. 1970 Mar;22(2):145–159. [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Medical Genetics are provided here courtesy of BMJ Publishing Group

RESOURCES