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. 1984 Aug;39(8):617–623. doi: 10.1136/thx.39.8.617

Carcinoid tumours of the bronchus: a 33 year experience.

R Hurt, M Bates
PMCID: PMC1020517  PMID: 6089366

Abstract

The term adenoma of the bronchus is discussed, and 79 cases of bronchial carcinoid seen from 1951 to 1983 are reviewed. The symptoms, radiological findings, and bronchoscopic appearances are described. There was no case of the carcinoid syndrome. In no case did haemorrhage cause any serious problem after biopsy at rigid bronchoscopy. In three patients the tumour was reported to be an oat cell carcinoma-in two on the basis of material obtained at fibreoptic bronchoscopy. Resection was by pneumonectomy in 10 cases, lobectomy in 52, segmentectomy in six, a bronchoplastic procedure without resection of lung in seven cases, enucleation in two, and a wedge resection in one case. There was one case of atypical carcinoid which was found at operation to be unresectable. A 5-30 year follow up in 57 cases revealed a recurrence of tumour in two cases, nine and 16 years after lung resection. No recurrence occurred in the nine cases treated by conservative bronchial resection with conservation of lung tissue. An actuarially assessed life table analysis shows survival rates of 94% after 10 years, 80% after 15 years, and 64% after 25 years without recurrence. The similarity of carcinoid to oat cell carcinoma is noted and the serious clinical implications of this are analysed, especially in view of the increasing use of fibreoptic bronchoscopy. The malignant potential of carcinoid and the extent of pulmonary resection is discussed. It is concluded that a carcinoid tumour of the lung has only slight malignant potential and that it may be treated by bronchotomy or sleeve resection of the bronchus in suitable cases. If serious infective changes have occurred in the lung distal to the tumour or if the tumour has extended into the lung parenchyma (88% of cases in this series) lung resection will be necessary. The follow up period should be for at least 25 years, in view of the incidence of late recurrence.

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Selected References

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  1. Aberg T., Blöndal T., Nõu E., Malmaeus J. The choice of operation for bronchial carcinoids. Ann Thorac Surg. 1981 Jul;32(1):19–22. doi: 10.1016/s0003-4975(10)61367-7. [DOI] [PubMed] [Google Scholar]
  2. Anderson R. P., Bonchek L. I., Grunkemeier G. L., Lambert L. E., Starr A. The analysis and presentation of surgical results by actuarial methods. J Surg Res. 1974 Mar;16(3):224–230. doi: 10.1016/0022-4804(74)90035-3. [DOI] [PubMed] [Google Scholar]
  3. Arrigoni M. G., Woolner L. B., Bernatz P. E. Atypical carcinoid tumors of the lung. J Thorac Cardiovasc Surg. 1972 Sep;64(3):413–421. [PubMed] [Google Scholar]
  4. Batson J. F., Gale J. W., Hickey R. C. Bronchial adenomata. A clinical résumé. Arch Surg. 1966 Apr;92(4):623–630. doi: 10.1001/archsurg.1966.01320220179028. [DOI] [PubMed] [Google Scholar]
  5. Bensch K. G., Corrin B., Pariente R., Spencer H. Oat-cell carcinoma of the lung. Its origin and relationship to bronchial carcinoid. Cancer. 1968 Dec;22(6):1163–1172. doi: 10.1002/1097-0142(196811)22:6<1163::aid-cncr2820220612>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  6. Blondal T., Grimelius L., Nou E., Wilander E., Aberg T. Argyrophil carcinoid tumors of the lung. Incidence, clinical study, and follow-up of 46 patients. Chest. 1980 Dec;78(6):840–844. doi: 10.1378/chest.78.6.840. [DOI] [PubMed] [Google Scholar]
  7. Borggreve J. R. Een reeds 33 jaar bestaand bronchusadenoom. Ned Tijdschr Geneeskd. 1966 Aug 27;110(35):1532–1535. [PubMed] [Google Scholar]
  8. Bower G. Bronchial adenoma. A review of twenty-eight cases. Am Rev Respir Dis. 1965 Oct;92(4):558–563. doi: 10.1164/arrd.1965.92.4.558. [DOI] [PubMed] [Google Scholar]
  9. Boyd A. D., Spencer F. C., Lind A. Why has bronchial resection and anastomosis been reported infrequently for treatment of bronchial adenoma? J Thorac Cardiovasc Surg. 1970 Mar;59(3):359–365. [PubMed] [Google Scholar]
  10. Burcharth F., Axelsson C. Bronchial adenomas. Thorax. 1972 Jul;27(4):442–449. doi: 10.1136/thx.27.4.442. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. CARLENS E., WIKLUND T., BERGSTRAND A. Bronchial adenoma; a report of 70 cases and a critical analysis of the literature. Acta Chir Scand Suppl. 1954;185:7–55. [PubMed] [Google Scholar]
  12. Cooper D. K., Belcher J. R. Conservative surgery for bronchial adenomata. Thorax. 1976 Feb;31(1):44–48. doi: 10.1136/thx.31.1.44. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. De Grüneck J. M., Naef A. P., Baumann R. P. Adénomes bronchiques. Schweiz Med Wochenschr. 1977 Feb 26;107(8):259–266. [PubMed] [Google Scholar]
  14. FELTON W. L., 2nd, LIEBOW A. A., LINDSKOG G. E. Peripheral and multiple bronchial adenomas. Cancer. 1953 May;6(3):555–567. doi: 10.1002/1097-0142(195305)6:3<555::aid-cncr2820060312>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
  15. FROHLICH F. Die Helle Zelle der Bronchialschleimhaut und ihre Beziehungen zum Problem der Chemoreceptoren. Frankf Z Pathol. 1949 Apr;60(3-4):517-59, illust. [PubMed] [Google Scholar]
  16. Fisher E. R., Palekar A., Paulson J. D. Comparative histopathologic, histochemical, electron microscopic and tissue culture studies of bronchial carcinoids and oat cell carcinomas of lung. Am J Clin Pathol. 1978 Feb;69(2):165–172. doi: 10.1093/ajcp/69.2.165. [DOI] [PubMed] [Google Scholar]
  17. GEBAUER P. W. Reconstructive surgery of the trachea and bronchi: late results with dermal grafts. J Thorac Surg. 1951 Dec;22(6):568–584. [PubMed] [Google Scholar]
  18. Giustra P. E., Stassa G. The multiple presentations of bronchial adenomas. Radiology. 1969 Nov;93(5):1013–1019. doi: 10.1148/93.5.1013. [DOI] [PubMed] [Google Scholar]
  19. Heard B. E., Dewar A., Firmin R. K., Lennox S. C. One very rare and one new tracheal tumour found by electron microscopy: glomus tumour and acinic cell tumour resembling carcinoid tumours by light microscopy. Thorax. 1982 Feb;37(2):97–103. doi: 10.1136/thx.37.2.97. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Heimburger I. L., Kilman J. W., Battersby J. S. Peripheral bronchial adenomas. J Thorac Cardiovasc Surg. 1966 Oct;52(4):542–549. [PubMed] [Google Scholar]
  21. Hurt R. Benign tumours of the bronchus and trachea, 1951-1981. Ann R Coll Surg Engl. 1984 Jan;66(1):22–26. [PMC free article] [PubMed] [Google Scholar]
  22. Jensik R. J., Faber L. P., Brown C. M., Kittle C. F. Bronchoplastic and conservative resectional procedures for bronchial adenoma. J Thorac Cardiovasc Surg. 1974 Oct;68(4):556–565. [PubMed] [Google Scholar]
  23. Kennedy A. The diagnosis of pulmonary carcinoid tumours. Br J Dis Chest. 1979 Jan;73(1):71–80. [PubMed] [Google Scholar]
  24. Kennedy A. The diagnosis of pulmonary carcinoid tumours. Br J Dis Chest. 1979 Jan;73(1):71–80. [PubMed] [Google Scholar]
  25. Lawson R. M., Ramanathan L., Hurley G., Hinson K. W., Lennox S. C. Bronchial adenoma: review of 18-year experience at the Brompton Hospital. Thorax. 1976 Jun;31(3):245–253. doi: 10.1136/thx.31.3.245. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. MARKEL S. F., ABELL M. R., HAIGHT C., FRENCH A. J. NEOPLASMS OF BRONCHUS COMMONLY DESIGNATED AS ADENOMAS. Cancer. 1964 May;17:590–608. doi: 10.1002/1097-0142(196405)17:5<590::aid-cncr2820170508>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  27. Meffert W. G., Lindskog G. E. Bronchial adenoma. J Thorac Cardiovasc Surg. 1970 Apr;59(4):588–602. [PubMed] [Google Scholar]
  28. Miller R. E., Hopeman A. R. Bronchial adenoma. Ann Thorac Surg. 1975 Apr;19(4):378–385. doi: 10.1016/s0003-4975(10)64038-6. [DOI] [PubMed] [Google Scholar]
  29. O'Grady W. P., McDivitt R. W., Holman C. W., Moore S. W. Bronchial adenomas. Arch Surg. 1970 Nov;101(5):558–561. doi: 10.1001/archsurg.1970.01340290014004. [DOI] [PubMed] [Google Scholar]
  30. OVERHOLT R. H., BOUGAS J. A., MORSE D. P. Bronchial adenoma; a study of 60 patients with resections. Am Rev Tuberc. 1957 Jun;75(6):865–884. doi: 10.1164/artpd.1957.75.6.865. [DOI] [PubMed] [Google Scholar]
  31. Okike N., Bernatz P. E., Payne W. S., Woolner L. B., Leonard P. F. Bronchoplastic procedures in the treatment of carcinoid tumors of the tracheobronchial tree. J Thorac Cardiovasc Surg. 1978 Sep;76(3):281–291. [PubMed] [Google Scholar]
  32. Okike N., Bernatz P. E., Woolner L. B. Carcinoid tumors of the lung. Ann Thorac Surg. 1976 Sep;22(3):270–277. doi: 10.1016/s0003-4975(10)64915-6. [DOI] [PubMed] [Google Scholar]
  33. Paulson D. L., Reisch J. S. Long-term survival after resection for bronchogenic carcinoma. Ann Surg. 1976 Sep;184(3):324–332. doi: 10.1097/00000658-197609000-00010. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Pearse A. G. The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. J Histochem Cytochem. 1969 May;17(5):303–313. doi: 10.1177/17.5.303. [DOI] [PubMed] [Google Scholar]
  35. RABIN C. B., NEUHOF H. Adenoma of the bronchus. J Thorac Surg. 1949 Apr;18(2):149–163. [PubMed] [Google Scholar]
  36. Roenspies U., Pfenninger E., Otto R., Senning A. Bronchialkarzinoide. Thoraxchir Vask Chir. 1976 Jun;24(3):154–163. doi: 10.1055/s-0028-1095899. [DOI] [PubMed] [Google Scholar]
  37. SOUTTER L., SNIFFEN R. C., ROBBINS L. L. A clinical survey of adenomas of the trachea and bronchus in a general hospital. J Thorac Surg. 1954 Oct;28(4):412-28; discussion, 428-30. [PubMed] [Google Scholar]
  38. SZABO G., SOLTI F., REV J., MEGYESI K. Effect of chlorpromazine on renal haemodynamics and function in congestive heart failure; preliminary report. Br Med J. 1957 Apr 13;1(5023):865–866. doi: 10.1136/bmj.1.5023.865. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Salyer D. C., Salyer W. R., Eggleston J. C. Bronchial carcinoid tumors. Cancer. 1975 Oct;36(4):1522–1537. doi: 10.1002/1097-0142(197510)36:4<1522::aid-cncr2820360447>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  40. Smith R. A. Bronchial carcinoid tumours. Thorax. 1969 Jan;24(1):43–50. doi: 10.1136/thx.24.1.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Todd T. R., Cooper J. D., Weissberg D., Delarue N. C., Pearson F. G. Bronchial carcinoid tumors: twenty years' experience. J Thorac Cardiovasc Surg. 1980 Apr;79(4):532–536. [PubMed] [Google Scholar]
  42. Tolis G. A., Fry W. A., Head L., Shields T. W. Bronchial adenomas. Surg Gynecol Obstet. 1972 Apr;134(4):605–610. [PubMed] [Google Scholar]
  43. Turnbull A. D., Huvos A. G., Goodner J. T., Beattie E. J., Jr The malignant potential of bronchial adenoma. Ann Thorac Surg. 1972 Nov;14(5):453–464. doi: 10.1016/s0003-4975(10)65256-3. [DOI] [PubMed] [Google Scholar]
  44. WEISS L., INGRAM M. Adenomatoid bronchial tumors. A consideration of the carcinoid tumors and the salivary tumors of the bronchial tree. Cancer. 1961 Jan-Feb;14:161–178. doi: 10.1002/1097-0142(196101/02)14:1<161::aid-cncr2820140120>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  45. WILKINS E. W., Jr, DARLING R. C., SOUTTER L., SNIFFEN R. C. A CONTINUING CLINICAL SURVEY OF ADENOMAS OF THE TRACHEA AND BRONCHUS IN A GENERAL HOSPITAL. J Thorac Cardiovasc Surg. 1963 Sep;46:279–291. [PubMed] [Google Scholar]
  46. ZELLOS S. Bronchial adenoma. Thorax. 1962 Mar;17:61–68. doi: 10.1136/thx.17.1.61. [DOI] [PMC free article] [PubMed] [Google Scholar]

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