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. 1992 Dec;47(12):993–1000. doi: 10.1136/thx.47.12.993

The use of the nose to study the inflammatory response of the respiratory tract.

C G Persson, C Svensson, L Greiff, M Anderson, P Wollmer, U Alkner, I Erjefält
PMCID: PMC1021088  PMID: 1494783

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Selected References

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  1. Aberg N. Asthma and allergic rhinitis in Swedish conscripts. Clin Exp Allergy. 1989 Jan;19(1):59–63. doi: 10.1111/j.1365-2222.1989.tb02345.x. [DOI] [PubMed] [Google Scholar]
  2. Andersson M., Nolte H., Baumgarten C., Pipkorn U. Suppressive effect of loratadine on allergen-induced histamine release in the nose. Allergy. 1991 Oct;46(7):540–546. doi: 10.1111/j.1398-9995.1991.tb00618.x. [DOI] [PubMed] [Google Scholar]
  3. Aubier M., Levy J., Clerici C., Neukirch F., Herman D. Different effects of nasal and bronchial glucocorticosteroid administration on bronchial hyperresponsiveness in patients with allergic rhinitis. Am Rev Respir Dis. 1992 Jul;146(1):122–126. doi: 10.1164/ajrccm/146.1.122. [DOI] [PubMed] [Google Scholar]
  4. BORDLEY J. E., CAREY R. A. Preliminary observations on the effect of adrenocorticotropic hormone in allergic diseases. Bull Johns Hopkins Hosp. 1949 Nov;85(5):396–398. [PubMed] [Google Scholar]
  5. Bende M., Lindqvist N., Pipkorn U. Effect of a topical glucocorticoid, budesonide, on nasal mucosal blood flow as measured with 133Xe wash-out technique. Allergy. 1983 Oct;38(7):461–464. doi: 10.1111/j.1398-9995.1983.tb02354.x. [DOI] [PubMed] [Google Scholar]
  6. Castells M., Schwartz L. B. Tryptase levels in nasal-lavage fluid as an indicator of the immediate allergic response. J Allergy Clin Immunol. 1988 Sep;82(3 Pt 1):348–355. doi: 10.1016/0091-6749(88)90005-x. [DOI] [PubMed] [Google Scholar]
  7. Cox G., Ohtoshi T., Vancheri C., Denburg J. A., Dolovich J., Gauldie J., Jordana M. Promotion of eosinophil survival by human bronchial epithelial cells and its modulation by steroids. Am J Respir Cell Mol Biol. 1991 Jun;4(6):525–531. doi: 10.1165/ajrcmb/4.6.525. [DOI] [PubMed] [Google Scholar]
  8. Dahl R., Johansson S. A. Importance of duration of treatment with inhaled budesonide on the immediate and late bronchial reaction. Eur J Respir Dis Suppl. 1982;122:167–175. [PubMed] [Google Scholar]
  9. Dixon W. E. Contributions to the physiology of the lungs: Part I. The bronchial muscles, their innervation, and the action of drugs upon them. J Physiol. 1903 Mar 16;29(2):97–173. doi: 10.1113/jphysiol.1903.sp000947. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Elwood R. K., Kennedy S., Belzberg A., Hogg J. C., Paré P. D. Respiratory mucosal permeability in asthma. Am Rev Respir Dis. 1983 Sep;128(3):523–527. doi: 10.1164/arrd.1983.128.3.523. [DOI] [PubMed] [Google Scholar]
  11. Enerbäck L., Pipkorn U., Granerus G. Intraepithelial migration of nasal mucosal mast cells in hay fever. Int Arch Allergy Appl Immunol. 1986;80(1):44–51. doi: 10.1159/000234024. [DOI] [PubMed] [Google Scholar]
  12. Erjefält I., Persson C. G. Allergen, bradykinin, and capsaicin increase outward but not inward macromolecular permeability of guinea-pig tracheobronchial mucosa. Clin Exp Allergy. 1991 Mar;21(2):217–224. doi: 10.1111/j.1365-2222.1991.tb00833.x. [DOI] [PubMed] [Google Scholar]
  13. Erjefält I., Persson C. G. Inflammatory passage of plasma macromolecules into airway wall and lumen. Pulm Pharmacol. 1989;2(2):93–102. doi: 10.1016/0952-0600(89)90030-6. [DOI] [PubMed] [Google Scholar]
  14. Erjefält I., Persson C. G. Long duration and high potency of antiexudative effects of formoterol in guinea-pig tracheobronchial airways. Am Rev Respir Dis. 1991 Oct;144(4):788–791. doi: 10.1164/ajrccm/144.4.788. [DOI] [PubMed] [Google Scholar]
  15. Forsberg K., Karlsson J. A., Zackrisson C., Persson C. G. Selective inhibition of cough and bronchoconstriction in conscious guinea pigs. Respiration. 1992;59(2):72–76. doi: 10.1159/000196030. [DOI] [PubMed] [Google Scholar]
  16. GANDEVIA B. RESPIRATORY SYMPTOMS AND VENTILATORY CAPACITY IN MEN EXPOSED TO ISOCYANATE VAPOUR. Australas Ann Med. 1964 May;13:157–166. doi: 10.1111/imj.1964.13.2.157. [DOI] [PubMed] [Google Scholar]
  17. Garofalo R., Kimpen J. L., Welliver R. C., Ogra P. L. Eosinophil degranulation in the respiratory tract during naturally acquired respiratory syncytial virus infection. J Pediatr. 1992 Jan;120(1):28–32. doi: 10.1016/s0022-3476(05)80592-x. [DOI] [PubMed] [Google Scholar]
  18. Gauldie J., Jordana M., Cox G., Ohtoshi T., Dolovich J., Denburg J. Fibroblasts and other structural cells in airway inflammation. Am Rev Respir Dis. 1992 Feb;145(2 Pt 2):S14–S17. doi: 10.1164/ajrccm/145.2_Pt_2.S14. [DOI] [PubMed] [Google Scholar]
  19. Gordon J. R., Burd P. R., Galli S. J. Mast cells as a source of multifunctional cytokines. Immunol Today. 1990 Dec;11(12):458–464. doi: 10.1016/0167-5699(90)90176-a. [DOI] [PubMed] [Google Scholar]
  20. Greiff L., Erjefält I., Wollmer P., Pipkorn U., Persson C. G. Effects of histamine, ethanol, and a detergent on exudation and absorption across guinea pig airway mucosa in vivo. Thorax. 1991 Oct;46(10):700–705. doi: 10.1136/thx.46.10.700. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Greiff L., Pipkorn U., Alkner U., Persson C. G. The 'nasal pool' device applies controlled concentrations of solutes on human nasal airway mucosa and samples its surface exudations/secretions. Clin Exp Allergy. 1990 May;20(3):253–259. doi: 10.1111/j.1365-2222.1990.tb02680.x. [DOI] [PubMed] [Google Scholar]
  22. Greiff L., Wollmer P., Pipkorn U., Persson C. G. Absorption of 51Cr EDTA across the human nasal airway barriers in the presence of topical histamine. Thorax. 1991 Sep;46(9):630–632. doi: 10.1136/thx.46.9.630. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Gustafsson B. G., Persson C. G. Asymmetrical effects of increases in hydrostatic pressure on macromolecular movement across the airway mucosa. A study in guinea-pig tracheal tube preparations. Clin Exp Allergy. 1991 Jan;21(1):121–126. doi: 10.1111/j.1365-2222.1991.tb00813.x. [DOI] [PubMed] [Google Scholar]
  24. Hechtman D. H., Cybulsky M. I., Fuchs H. J., Baker J. B., Gimbrone M. A., Jr Intravascular IL-8. Inhibitor of polymorphonuclear leukocyte accumulation at sites of acute inflammation. J Immunol. 1991 Aug 1;147(3):883–892. [PubMed] [Google Scholar]
  25. Henriksen J. M., Wenzel A. Effect of an intranasally administered corticosteroid (budesonide) on nasal obstruction, mouth breathing, and asthma. Am Rev Respir Dis. 1984 Dec;130(6):1014–1018. doi: 10.1164/arrd.1984.130.6.1014. [DOI] [PubMed] [Google Scholar]
  26. Holmberg K., Bake B., Pipkorn U. The effect of topical nasal anaesthesia on allergen-induced symptoms, obstruction and blood flow. Clin Exp Allergy. 1989 Jul;19(4):443–447. doi: 10.1111/j.1365-2222.1989.tb02412.x. [DOI] [PubMed] [Google Scholar]
  27. Holt P. G., McMenamin C., Schon-Hegrad M. A., Strickland D., Nelson D., Wilkes L., Bilyk N., Oliver J., Holt B. J., McMenamin P. G. Immunoregulation of asthma: control of T-lymphocyte activation in the respiratory tract. Eur Respir J Suppl. 1991 Apr;13:6s–15s. [PubMed] [Google Scholar]
  28. Howarth P. H. Histamine and asthma: an appraisal based on specific H1-receptor antagonism. Clin Exp Allergy. 1990 Aug;20 (Suppl 2):31–41. doi: 10.1111/j.1365-2222.1990.tb02459.x. [DOI] [PubMed] [Google Scholar]
  29. Juliusson S., Holmberg K., Baumgarten C. R., Olsson M., Enander I., Pipkorn U. Tryptase in nasal lavage fluid after local allergen challenge. Relationship to histamine levels and TAME-esterase activity. Allergy. 1991 Aug;46(6):459–465. doi: 10.1111/j.1398-9995.1991.tb04225.x. [DOI] [PubMed] [Google Scholar]
  30. Klementsson H., Andersson M. Eosinophil chemotactic activity of topical PAF on the human nasal mucosa. Eur J Clin Pharmacol. 1992;42(3):295–299. doi: 10.1007/BF00266351. [DOI] [PubMed] [Google Scholar]
  31. Klementsson H., Svensson C., Andersson M., Venge P., Pipkorn U., Persson C. G. Eosinophils, secretory responsiveness and glucocorticoid-induced effects on the nasal mucosa during a weak pollen season. Clin Exp Allergy. 1991 Nov;21(6):705–710. doi: 10.1111/j.1365-2222.1991.tb03199.x. [DOI] [PubMed] [Google Scholar]
  32. Klementsson H., Venge P., Andersson M., Pipkorn U. Allergen-induced changes in nasal secretory responsiveness and eosinophil granulocytes. Acta Otolaryngol. 1991;111(4):776–784. doi: 10.3109/00016489109138412. [DOI] [PubMed] [Google Scholar]
  33. Kovacs J. A., Gill V., Swan J. C., Ognibene F., Shelhamer J., Parrillo J. E., Masur H. Prospective evaluation of a monoclonal antibody in diagnosis of Pneumocystis carinii pneumonia. Lancet. 1986 Jul 5;2(8497):1–3. doi: 10.1016/s0140-6736(86)92555-9. [DOI] [PubMed] [Google Scholar]
  34. Lozewicz S., Wells C., Gomez E., Ferguson H., Richman P., Devalia J., Davies R. J. Morphological integrity of the bronchial epithelium in mild asthma. Thorax. 1990 Jan;45(1):12–15. doi: 10.1136/thx.45.1.12. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Midgren B., Hansson L., Karlsson J. A., Simonsson B. G., Persson C. G. Capsaicin-induced cough in humans. Am Rev Respir Dis. 1992 Aug;146(2):347–351. doi: 10.1164/ajrccm/146.2.347. [DOI] [PubMed] [Google Scholar]
  36. Naclerio R. M., Meier H. L., Kagey-Sobotka A., Adkinson N. F., Jr, Meyers D. A., Norman P. S., Lichtenstein L. M. Mediator release after nasal airway challenge with allergen. Am Rev Respir Dis. 1983 Oct;128(4):597–602. doi: 10.1164/arrd.1983.128.4.597. [DOI] [PubMed] [Google Scholar]
  37. Naclerio R. M., Meier H. L., Kagey-Sobotka A., Adkinson N. F., Jr, Meyers D. A., Norman P. S., Lichtenstein L. M. Mediator release after nasal airway challenge with allergen. Am Rev Respir Dis. 1983 Oct;128(4):597–602. doi: 10.1164/arrd.1983.128.4.597. [DOI] [PubMed] [Google Scholar]
  38. Persson C. G., Erjefält I., Alkner U., Baumgarten C., Greiff L., Gustafsson B., Luts A., Pipkorn U., Sundler F., Svensson C. Plasma exudation as a first line respiratory mucosal defence. Clin Exp Allergy. 1991 Jan;21(1):17–24. doi: 10.1111/j.1365-2222.1991.tb00799.x. [DOI] [PubMed] [Google Scholar]
  39. Persson C. G., Erjefält I., Gustafsson B., Luts A. Subepithelial hydrostatic pressure may regulate plasma exudation across the mucosa. Int Arch Allergy Appl Immunol. 1990;92(2):148–153. doi: 10.1159/000235206. [DOI] [PubMed] [Google Scholar]
  40. Persson C. G. Glucocorticoids for asthma--early contributions. Pulm Pharmacol. 1989;2(3):163–166. doi: 10.1016/0952-0600(89)90042-2. [DOI] [PubMed] [Google Scholar]
  41. Persson C. G. Ipecacuanha asthma: more lessons. Thorax. 1991 Jun;46(6):467–468. doi: 10.1136/thx.46.6.467-c. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Persson C. G. Plasma exudation and asthma. Lung. 1988;166(1):1–23. doi: 10.1007/BF02714025. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Persson C. G. Plasma exudation in the airways: mechanisms and function. Eur Respir J. 1991 Nov;4(10):1268–1274. [PubMed] [Google Scholar]
  44. Pipkorn U., Enerbäck L. A method for the preparation of imprints from the nasal mucosa. J Immunol Methods. 1984 Oct 12;73(1):133–137. doi: 10.1016/0022-1759(84)90038-3. [DOI] [PubMed] [Google Scholar]
  45. Pipkorn U., Karlsson G., Enerback L. The cellular response of the human allergic mucosa to natural allergen exposure. J Allergy Clin Immunol. 1988 Dec;82(6):1046–1054. doi: 10.1016/0091-6749(88)90143-1. [DOI] [PubMed] [Google Scholar]
  46. Pipkorn U., Proud D., Lichtenstein L. M., Kagey-Sobotka A., Norman P. S., Naclerio R. M. Inhibition of mediator release in allergic rhinitis by pretreatment with topical glucocorticosteroids. N Engl J Med. 1987 Jun 11;316(24):1506–1510. doi: 10.1056/NEJM198706113162403. [DOI] [PubMed] [Google Scholar]
  47. Pipkorn U., Rundcrantz H., Lindqvist N. Budesonide - a new nasal steroid. Rhinology. 1980 Dec;18(4):171–175. [PubMed] [Google Scholar]
  48. Poulter L. W., Norris A., Power C., Condez A., Burnes H., Schmekel B., Burke C. T cell dominated inflammatory reactions in the bronchioles of asymptomatic asthmatics are also present in the nasal mucosa. Postgrad Med J. 1991 Aug;67(790):747–753. doi: 10.1136/pgmj.67.790.747. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Raphael G. D., Druce H. M., Baraniuk J. N., Kaliner M. A. Pathophysiology of rhinitis. 1. Assessment of the sources of protein in methacholine-induced nasal secretions. Am Rev Respir Dis. 1988 Aug;138(2):413–420. doi: 10.1164/ajrccm/138.2.413. [DOI] [PubMed] [Google Scholar]
  50. Reed C. E., Marcoux J. P., Welsh P. W. Effects of topical nasal treatment on asthma symptoms. J Allergy Clin Immunol. 1988 May;81(5 Pt 2):1042–1047. doi: 10.1016/0091-6749(88)90177-7. [DOI] [PubMed] [Google Scholar]
  51. Stjärne P., Lundblad L., Lundberg J. M., Anggård A. Capsaicin and nicotine-sensitive afferent neurones and nasal secretion in healthy human volunteers and in patients with vasomotor rhinitis. Br J Pharmacol. 1989 Mar;96(3):693–701. doi: 10.1111/j.1476-5381.1989.tb11870.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. Svensson C., Andersson M., Persson C. G., Venge P., Alkner U., Pipkorn U. Albumin, bradykinins, and eosinophil cationic protein on the nasal mucosal surface in patients with hay fever during natural allergen exposure. J Allergy Clin Immunol. 1990 May;85(5):828–833. doi: 10.1016/0091-6749(90)90064-b. [DOI] [PubMed] [Google Scholar]
  53. Svensson C., Baumgarten C. R., Pipkorn U., Alkner U., Persson C. G. Reversibility and reproducibility of histamine induced plasma leakage in nasal airways. Thorax. 1989 Jan;44(1):13–18. doi: 10.1136/thx.44.1.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Söderberg M., Hellström S., Sandström T., Lundgren R., Bergh A. Structural characterization of bronchial mucosal biopsies from healthy volunteers: a light and electron microscopical study. Eur Respir J. 1990 Mar;3(3):261–266. [PubMed] [Google Scholar]
  55. Vachier I., Godard P., Michel F. B., Descomps B., Damon M. Expression aberrante des antigènes HLA-DR du CMH classe II dans les cellules épithéliales bronchiques de l'asthmatique. C R Acad Sci III. 1990;311(10):341–346. [PubMed] [Google Scholar]
  56. Van de Graaf E. A., Out T. A., Roos C. M., Jansen H. M. Respiratory membrane permeability and bronchial hyperreactivity in patients with stable asthma. Effects of therapy with inhaled steroids. Am Rev Respir Dis. 1991 Feb;143(2):362–368. doi: 10.1164/ajrccm/143.2.362. [DOI] [PubMed] [Google Scholar]
  57. Varney V. A., Jacobson M. R., Sudderick R. M., Robinson D. S., Irani A. M., Schwartz L. B., Mackay I. S., Kay A. B., Durham S. R. Immunohistology of the nasal mucosa following allergen-induced rhinitis. Identification of activated T lymphocytes, eosinophils, and neutrophils. Am Rev Respir Dis. 1992 Jul;146(1):170–176. doi: 10.1164/ajrccm/146.1.170. [DOI] [PubMed] [Google Scholar]
  58. Venge P., Brattsand R., Laitinen L. A., Persson C. G. Which markers of inflammation should be used in therapeutic intervention studies of CB/COAD? Agents Actions Suppl. 1990;30:289–294. doi: 10.1007/978-3-0348-7488-5_23. [DOI] [PubMed] [Google Scholar]
  59. Vilsvik J. S., Jennssen A. O., Walstad R. The effect of beclomethasone dipropionate aerosol on allergen induced nasal stenosis. Clin Allergy. 1975 Sep;5(3):291–294. doi: 10.1111/j.1365-2222.1975.tb01865.x. [DOI] [PubMed] [Google Scholar]
  60. Walters E. H., Gardiner P. V. Bronchoalveolar lavage as a research tool. Thorax. 1991 Sep;46(9):613–618. doi: 10.1136/thx.46.9.613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. Ying S., Robinson D. S., Varney V., Meng Q., Tsicopoulos A., Moqbel R., Durham S. R., Kay A. B., Hamid Q. TNF alpha mRNA expression in allergic inflammation. Clin Exp Allergy. 1991 Nov;21(6):745–750. doi: 10.1111/j.1365-2222.1991.tb03205.x. [DOI] [PubMed] [Google Scholar]

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