Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1951 Feb;4(1):1–36. doi: 10.1136/jcp.4.1.1

A Review of Modern Methods in Histochemistry

A G Everson Pearse 1
PMCID: PMC1023353  PMID: 16810901

Full text

PDF
3

Images in this article

16-2Image
on p.16-2
16-2Image
on p.16-2
16-2Image
on p.16-2
11Image
on p.11
11Image
on p.11
11Image
on p.11
11Image
on p.11
11Image
on p.11
1Image
on p.1
9Image
on p.9
9Image
on p.9
9Image
on p.9
9Image
on p.9
16-1Image
on p.16-1
16-1Image
on p.16-1
16-1Image
on p.16-1
10Image
on p.10
10Image
on p.10
12Image
on p.12
13Image
on p.13
13Image
on p.13
14Image
on p.14
14Image
on p.14
21Image
on p.21
24Image
on p.24
24Image
on p.24
28Image
on p.28

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atkinson E., Melvin S., Fox S. W. Some Properties of 2,3,5-Triphenyltetrazolium Chloride and Several Iodo Derivatives. Science. 1950 Apr 14;111(2885):385–387. doi: 10.1126/science.111.2885.385. [DOI] [PubMed] [Google Scholar]
  2. BOSCOTT R. J., MANDL A. M. The histochemical demonstration of ketosteroids in adrenal tissue. J Endocrinol. 1949 Oct;6(2):132–136. doi: 10.1677/joe.0.0060132. [DOI] [PubMed] [Google Scholar]
  3. Belfanti S., Contardi A., Ercoli A. Researches on the phosphatases: Inactivation and reactivation of the phosphatases of animal organs. Biochem J. 1935 Apr;29(4):842–846. doi: 10.1042/bj0290842. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. CATCHPOLE H. R. Distribution of glycoprotein hormones in the anterior pituitary gland of the rat. J Endocrinol. 1949 Oct;6(2):218-25, 2 pl. doi: 10.1677/joe.0.0060218. [DOI] [PubMed] [Google Scholar]
  5. DONIACH I., PELC S. R. Autoradiographs with radio-active iodine. Proc R Soc Med. 1949 Dec;42(12):957-9, illust. [PMC free article] [PubMed] [Google Scholar]
  6. Davidson J. N., Waymouth C. Tissue nucleic acids: 1. Ribonucleic acids and nucleotides in embryonic and adult tissue. Biochem J. 1944;38(1):39–50. doi: 10.1042/bj0380039. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. ERICKSON R. O., SAX K. B., OGUR M. Perchloric acid in the cytochemistry of pentose nucleic acid. Science. 1949 Nov 4;110(2862):472–illust. doi: 10.1126/science.110.2862.472. [DOI] [PubMed] [Google Scholar]
  8. Ellinger P. Lyochromes in the kidney. With a note on the quantitative estimation of lyochromes. Biochem J. 1938 Feb;32(2):376–382.1. doi: 10.1042/bj0320376. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. FEIGIN I., WOLF A., KABAT E. A. Histochemical studies on tissue enzymes. VI. A difficulty in the histochemical localization of alkaline phosphatase in nuclei. Am J Pathol. 1950 Jul;26(4):647–659. [PMC free article] [PubMed] [Google Scholar]
  10. FOLLIS R. H., Jr Studies on the chemical differentiation of developing cartilage and bone; general method; alkaline phosphatase activity. Bull Johns Hopkins Hosp. 1949 Nov;85(5):360–369. [PubMed] [Google Scholar]
  11. Glick D. Histochemical Localization of Adenosinetriphosphatase. Science. 1946 May 10;103(2680):599–599. doi: 10.1126/science.103.2680.599-a. [DOI] [PubMed] [Google Scholar]
  12. Goodspeed T. H., Uber F. M. Application of the Altmann Freezing-Drying Technique to Plant Cytology. Proc Natl Acad Sci U S A. 1934 Sep;20(9):495–501. doi: 10.1073/pnas.20.9.495. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. HALL J. E. Alkaline phosphatase in human endometrium. Am J Obstet Gynecol. 1950 Jul;60(1):212–216. doi: 10.1016/s0002-9378(16)39062-7. [DOI] [PubMed] [Google Scholar]
  14. HARRIS J. E., SLOANE J. F., KING D. T. New techniques in autoradiography. Nature. 1950 Jul 1;166(4209):25–26. doi: 10.1038/166025a0. [DOI] [PubMed] [Google Scholar]
  15. HUDACK S. S., BLUNT J. W., Jr A probable acid mucopolysaccharide present in granulation tissue. Proc Soc Exp Biol Med. 1949 Dec;72(3):526–528. doi: 10.3181/00379727-72-17487. [DOI] [PubMed] [Google Scholar]
  16. Hardy W. B., Wesbrook F. F. The Wandering Cells of the Alimentary Canal. J Physiol. 1895 Nov 16;18(5-6):490–4i3. doi: 10.1113/jphysiol.1895.sp000582. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Holt M. W., Cowing R. F., Warren S. Preparation of Radioautographs of Tissues without Loss of Water-Soluble P32. Science. 1949 Sep 30;110(2857):328–329. doi: 10.1126/science.110.2857.328. [DOI] [PubMed] [Google Scholar]
  18. KAUFMANN B. P., GAY H., McDONALD M. R. Localization of cellular proteins by enzymatic hydrolysis. Cold Spring Harb Symp Quant Biol. 1950;14:85–91. doi: 10.1101/sqb.1950.014.01.012. [DOI] [PubMed] [Google Scholar]
  19. Kabat E. A., Furth J. A histochemical study of the distribution of alkaline phosphatase in various normal and neoplastic tissues. Am J Pathol. 1941 May;17(3):303–318.5. [PMC free article] [PubMed] [Google Scholar]
  20. Laidlaw G. F., Blackberg S. N. Melanoma Studies: II. A Simple Technique for the Dopa Reaction. Am J Pathol. 1932 Sep;8(5):491–498. [PMC free article] [PubMed] [Google Scholar]
  21. MORRISON R. W., HACK M. H. Histochemical studies in Gaucher's disease. Am J Pathol. 1949 Jul;25(4):597–603. [PMC free article] [PubMed] [Google Scholar]
  22. Moog F. The Distribution of Phosphatase in the Spinal Cord of Chick Embryos of One to Eight Days' Incubation. Proc Natl Acad Sci U S A. 1943 Jun;29(6):176–183. doi: 10.1073/pnas.29.6.176. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. NEWMAN W., FEIGIN I. Histochemical studies on tissue enzymes; distribution of some enzyme systems which liberate phosphate at pH 9.2 as determined with various substrates and inhibitors; demonstration of three groups of enzymes. Am J Pathol. 1950 Mar;26(2):257-305, incl 7 pl. [PMC free article] [PubMed] [Google Scholar]
  24. NEWMAN W., KABAT E. A., WOLF A. Histochemical studies on tissue enzymes; a difficulty in enzyme localization in the acid range due to selective affinity of certain tissues for lead; its dependence on pH. Am J Pathol. 1950 May;26(3):489–503. [PMC free article] [PubMed] [Google Scholar]
  25. Pearse A. G. The Nature of Russell Bodies and Kurloff Bodies: Observations on the Cytochemistry of Plasma Cells and Reticulum Cells. J Clin Pathol. 1949 May;2(2):81–90. doi: 10.1136/jcp.2.2.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. RITTER H. B., OLESON J. J. Combined histochemical staining of acid polysaccharides of 1,2 glycol groupings in paraffin sections of rat tissues. Am J Pathol. 1950 Jul;26(4):639–645. [PMC free article] [PubMed] [Google Scholar]
  27. RUTENBURG A. M., GOFSTEIN R., SELIGMAN A. M. Preparation of a new tetrazolium salt which yields a blue pigment on reduction and its use in the demonstration of enzymes in normal and neoplastic tissues. Cancer Res. 1950 Feb;10(2):113–121. [PubMed] [Google Scholar]
  28. SESHACHAR B. R., FLICK E. W. Application of perchloric acid technique to protozoa. Science. 1949 Dec 16;110(2868):659–659. doi: 10.1126/science.110.2868.659. [DOI] [PubMed] [Google Scholar]
  29. SIBATANI A. Effects of histone and other proteins on the Feulgen reaction. Nature. 1950 Aug 26;166(4217):355–356. doi: 10.1038/166355a0. [DOI] [PubMed] [Google Scholar]
  30. SNEATH P. H. A. Histochemical demonstration of lipase. Nature. 1950 Oct 21;166(4225):699–700. doi: 10.1038/166699a0. [DOI] [PubMed] [Google Scholar]
  31. Stafford R. O., Atkinson W. B. Effect of Acetone and Alcohol Fixation and Paraffin Embedding on Activity of Acid and Alkaline Phosphatases in Rat Tissues. Science. 1948 Mar 12;107(2776):279–281. doi: 10.1126/science.107.2776.279. [DOI] [PubMed] [Google Scholar]
  32. Stirling W. On a New Method of preparing the Skin for Histological Examination. J Anat Physiol. 1875 Oct;10(Pt 1):185–186. [PMC free article] [PubMed] [Google Scholar]
  33. TAFT E. B. Melanin solubility in tissue sections. Nature. 1949 Dec 31;164(4183):1133–1133. doi: 10.1038/1641133b0. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES