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. 2023 Jun 5:1–49. Online ahead of print. doi: 10.1007/s11427-023-2346-1

Gut microbiota bridges dietary nutrients and host immunity

Lijuan Fan 1,#, Yaoyao Xia 1,#, Youxia Wang 1,#, Dandan Han 2,#, Yanli Liu 3,#, Jiahuan Li 4,#, Jie Fu 5,#, Leli Wang 6,#, Zhending Gan 1, Bingnan Liu 1, Jian Fu 1, Congrui Zhu 1, Zhenhua Wu 2, Jinbiao Zhao 2, Hui Han 7, Hao Wu 4, Yiwen He 6,8, Yulong Tang 6, Qingzhuo Zhang 1, Yibin Wang 3, Fan Zhang 3, Xin Zong 5,✉, Jie Yin 9,✉, Xihong Zhou 6,✉, Xiaojun Yang 3,✉, Junjun Wang 2,✉, Yulong Yin 6,9,✉, Wenkai Ren 1,✉
PMCID: PMC10247344  PMID: 37286860

Abstract

Dietary nutrients and the gut microbiota are increasingly recognized to cross-regulate and entrain each other, and thus affect host health and immune-mediated diseases. Here, we systematically review the current understanding linking dietary nutrients to gut microbiota-host immune interactions, emphasizing how this axis might influence host immunity in health and diseases. Of relevance, we highlight that the implications of gut microbiota-targeted dietary intervention could be harnessed in orchestrating a spectrum of immune-associated diseases.

Keywords: amino acid, carbohydrate, lipid, trace element, vitamin, gut microbiota, immunity

Acknowledgements

This work was supported by the National Key Research and Development Program of China (2021YFD1300700, 2021YFD1300201, 2022YFA1304201), the National Natural Science Foundation of China (32225047, U22A20510, 32125036, 32172750, 31972596, 31902170, 31630074, 32272916, 32102567), the Laboratory of Lingnan Modern Agriculture Project (NT2021005), the China Agricultural Research System of MOF and MARA (CARS-35), the Key Research and Development Project of Hainan Province (ZDYF2021XDNY177), the 111 Project (B16044), the Program for Shaanxi Science and Technology (2022KJXX-13). Our profound admiration and respect go to researchers in this field and in our laboratories, for their dedication and hard work. We apologize to scientists whose work is in this field if their papers are not cited owing to space limitations.

Footnotes

Compliance and ethics

The author(s) declare that they have no conflict of interest.

Contributed equally to this work

Contributor Information

Xin Zong, Email: zongxin@zju.edu.cn.

Jie Yin, Email: yinjie@hunau.edu.cn.

Xihong Zhou, Email: xhzhou@isa.ac.cn.

Xiaojun Yang, Email: yangxj@nwsuaf.edu.cn.

Junjun Wang, Email: wangjj@cau.edu.cn.

Yulong Yin, Email: yinyulong@isa.ac.cn.

Wenkai Ren, Email: renwenkai19@scau.edu.cn.

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