Skip to main content
PMC home page
British Heart Journal logoLink to British Heart Journal
. 1994 Sep;72(3 Suppl):S81–S86. doi: 10.1136/hrt.72.3_suppl.s81

How do ACE inhibitors reduce mortality in patients with left ventricular dysfunction with and without heart failure: remodelling, resetting, or sudden death?

John G F Cleland 1, Sundeep Puri 1
PMCID: PMC1025599  PMID: 7946810

Full text

PDF
S85

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anversa P., Beghi C., Kikkawa Y., Olivetti G. Myocardial infarction in rats. Infarct size, myocyte hypertrophy, and capillary growth. Circ Res. 1986 Jan;58(1):26–37. doi: 10.1161/01.res.58.1.26. [DOI] [PubMed] [Google Scholar]
  2. Bashir Y., Sneddon J. F., O'Nunain S., Paul V. E., Gibson S., Ward D. E., Camm A. J. Comparative electrophysiological effects of captopril or hydralazine combined with nitrate in patients with left ventricular dysfunction and inducible ventricular tachycardia. Br Heart J. 1992 May;67(5):355–360. doi: 10.1136/hrt.67.5.355. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bonaduce D., Petretta M., Arrichiello P., Conforti G., Montemurro M. V., Attisano T., Bianchi V., Morgano G. Effects of captopril treatment on left ventricular remodeling and function after anterior myocardial infarction: comparison with digitalis. J Am Coll Cardiol. 1992 Mar 15;19(4):858–863. doi: 10.1016/0735-1097(92)90532-r. [DOI] [PubMed] [Google Scholar]
  4. Cigarroa R. G., Lange R. A., Hillis L. D. Prognosis after acute myocardial infarction in patients with and without residual anterograde coronary blood flow. Am J Cardiol. 1989 Jul 15;64(3):155–160. doi: 10.1016/0002-9149(89)90449-9. [DOI] [PubMed] [Google Scholar]
  5. Cleland J. G. Ancillary diagnostic and therapeutic issues in cardiac failure. Curr Opin Cardiol. 1992 Jun;7(3):408–415. doi: 10.1097/00001573-199206000-00009. [DOI] [PubMed] [Google Scholar]
  6. Cleland J. G., Dargie H. J., Ball S. G., Gillen G., Hodsman G. P., Morton J. J., East B. W., Robertson I., Ford I., Robertson J. I. Effects of enalapril in heart failure: a double blind study of effects on exercise performance, renal function, hormones, and metabolic state. Br Heart J. 1985 Sep;54(3):305–312. doi: 10.1136/hrt.54.3.305. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cleland J. G., Dargie H. J., Hodsman G. P., Ball S. G., Robertson J. I., Morton J. J., East B. W., Robertson I., Murray G. D., Gillen G. Captopril in heart failure. A double blind controlled trial. Br Heart J. 1984 Nov;52(5):530–535. doi: 10.1136/hrt.52.5.530. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Cleland J. G., Gillen G., Dargie H. J. The effects of frusemide and angiotensin-converting enzyme inhibitors and their combination on cardiac and renal haemodynamics in heart failure. Eur Heart J. 1988 Feb;9(2):132–141. doi: 10.1093/oxfordjournals.eurheartj.a062466. [DOI] [PubMed] [Google Scholar]
  9. Cleland J. G., Shah D., Krikler S., Dritsas A., Nihoyannopoulos P., Frost G., Oakley C. M. Effects of lisinopril on cardiorespiratory, neuroendocrine, and renal function in patients with asymptomatic left ventricular dysfunction. Br Heart J. 1993 Jun;69(6):512–515. doi: 10.1136/hrt.69.6.512. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Cohn J. N., Archibald D. G., Ziesche S., Franciosa J. A., Harston W. E., Tristani F. E., Dunkman W. B., Jacobs W., Francis G. S., Flohr K. H. Effect of vasodilator therapy on mortality in chronic congestive heart failure. Results of a Veterans Administration Cooperative Study. N Engl J Med. 1986 Jun 12;314(24):1547–1552. doi: 10.1056/NEJM198606123142404. [DOI] [PubMed] [Google Scholar]
  11. Cohn J. N., Johnson G., Ziesche S., Cobb F., Francis G., Tristani F., Smith R., Dunkman W. B., Loeb H., Wong M. A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N Engl J Med. 1991 Aug 1;325(5):303–310. doi: 10.1056/NEJM199108013250502. [DOI] [PubMed] [Google Scholar]
  12. Davies M. J., Thomas A. Thrombosis and acute coronary-artery lesions in sudden cardiac ischemic death. N Engl J Med. 1984 May 3;310(18):1137–1140. doi: 10.1056/NEJM198405033101801. [DOI] [PubMed] [Google Scholar]
  13. Elefteriades J. A., Tolis G., Jr, Levi E., Mills L. K., Zaret B. L. Coronary artery bypass grafting in severe left ventricular dysfunction: excellent survival with improved ejection fraction and functional state. J Am Coll Cardiol. 1993 Nov 1;22(5):1411–1417. doi: 10.1016/0735-1097(93)90551-b. [DOI] [PubMed] [Google Scholar]
  14. Fonarow G. C., Chelimsky-Fallick C., Stevenson L. W., Luu M., Hamilton M. A., Moriguchi J. D., Tillisch J. H., Walden J. A., Albanese E. Effect of direct vasodilation with hydralazine versus angiotensin-converting enzyme inhibition with captopril on mortality in advanced heart failure: the Hy-C trial. J Am Coll Cardiol. 1992 Mar 15;19(4):842–850. doi: 10.1016/0735-1097(92)90529-v. [DOI] [PubMed] [Google Scholar]
  15. Gaudron P., Eilles C., Kugler I., Ertl G. Progressive left ventricular dysfunction and remodeling after myocardial infarction. Potential mechanisms and early predictors. Circulation. 1993 Mar;87(3):755–763. doi: 10.1161/01.cir.87.3.755. [DOI] [PubMed] [Google Scholar]
  16. Goldbourt U., Behar S., Reicher-Reiss H., Zion M., Mandelzweig L., Kaplinsky E. Early administration of nifedipine in suspected acute myocardial infarction. The Secondary Prevention Reinfarction Israel Nifedipine Trial 2 Study. Arch Intern Med. 1993 Feb 8;153(3):345–353. [PubMed] [Google Scholar]
  17. Goldstein R. E., Boccuzzi S. J., Cruess D., Nattel S. Diltiazem increases late-onset congestive heart failure in postinfarction patients with early reduction in ejection fraction. The Adverse Experience Committee; and the Multicenter Diltiazem Postinfarction Research Group. Circulation. 1991 Jan;83(1):52–60. doi: 10.1161/01.cir.83.1.52. [DOI] [PubMed] [Google Scholar]
  18. Gwilt D. J., Petri M., Lewis P. W., Nattrass M., Pentecost B. L. Myocardial infarct size and mortality in diabetic patients. Br Heart J. 1985 Nov;54(5):466–472. doi: 10.1136/hrt.54.5.466. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Gøtzsche C. O., Søgaard P., Ravkilde J., Thygesen K. Effects of captopril on left ventricular systolic and diastolic function after acute myocardial infarction. Am J Cardiol. 1992 Jul 15;70(2):156–160. doi: 10.1016/0002-9149(92)91268-9. [DOI] [PubMed] [Google Scholar]
  20. Hammerman H., Schoen F. J., Braunwald E., Kloner R. A. Drug-induced expansion of infarct: morphologic and functional correlations. Circulation. 1984 Mar;69(3):611–617. doi: 10.1161/01.cir.69.3.611. [DOI] [PubMed] [Google Scholar]
  21. Hammermeister K. E., DeRouen T. A., Dodge H. T. Variables predictive of survival in patients with coronary disease. Selection by univariate and multivariate analyses from the clinical, electrocardiographic, exercise, arteriographic, and quantitative angiographic evaluations. Circulation. 1979 Mar;59(3):421–430. doi: 10.1161/01.cir.59.3.421. [DOI] [PubMed] [Google Scholar]
  22. Hargreaves A. D., Kolettis T., Jacob A. J., Flint L. L., Turnbull L. W., Muir A. L., Boon N. A. Early vasodilator treatment in myocardial infarction: appropriate for the majority or minority? Br Heart J. 1992 Oct;68(4):369–373. doi: 10.1136/hrt.68.10.369. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Hirai T., Fujita M., Nakajima H., Asanoi H., Yamanishi K., Ohno A., Sasayama S. Importance of collateral circulation for prevention of left ventricular aneurysm formation in acute myocardial infarction. Circulation. 1989 Apr;79(4):791–796. doi: 10.1161/01.cir.79.4.791. [DOI] [PubMed] [Google Scholar]
  24. Jeremy R. W., Hackworthy R. A., Bautovich G., Hutton B. F., Harris P. J. Infarct artery perfusion and changes in left ventricular volume in the month after acute myocardial infarction. J Am Coll Cardiol. 1987 May;9(5):989–995. doi: 10.1016/s0735-1097(87)80298-x. [DOI] [PubMed] [Google Scholar]
  25. Jugdutt B. I., Warnica J. W. Intravenous nitroglycerin therapy to limit myocardial infarct size, expansion, and complications. Effect of timing, dosage, and infarct location. Circulation. 1988 Oct;78(4):906–919. doi: 10.1161/01.cir.78.4.906. [DOI] [PubMed] [Google Scholar]
  26. Keren A., Gottlieb S., Tzivoni D., Stern S., Yarom R., Billingham M. E., Popp R. L. Mildly dilated congestive cardiomyopathy. Use of prospective diagnostic criteria and description of the clinical course without heart transplantation. Circulation. 1990 Feb;81(2):506–517. doi: 10.1161/01.cir.81.2.506. [DOI] [PubMed] [Google Scholar]
  27. Keren G., Pardes A., Eschar Y., Hansch E., Scherez J., Laniado S. Left ventricular filling dynamics by Doppler echocardiography in dilated cardiomyopathy: one-year follow-up in patients treated with captopril compared to placebo. Cardiology. 1992;81(4-5):196–206. doi: 10.1159/000175805. [DOI] [PubMed] [Google Scholar]
  28. Komajda M., Jais J. P., Reeves F., Goldfarb B., Bouhour J. B., Juillieres Y., Lanfranchi J., Peycelon P., Geslin P., Carrie D. Factors predicting mortality in idiopathic dilated cardiomyopathy. Eur Heart J. 1990 Sep;11(9):824–831. doi: 10.1093/oxfordjournals.eurheartj.a059803. [DOI] [PubMed] [Google Scholar]
  29. Konstam M. A., Kronenberg M. W., Rousseau M. F., Udelson J. E., Melin J., Stewart D., Dolan N., Edens T. R., Ahn S., Kinan D. Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dilatation in patients with asymptomatic systolic dysfunction. SOLVD (Studies of Left Ventricular Dysfunction) Investigators. Circulation. 1993 Nov;88(5 Pt 1):2277–2283. doi: 10.1161/01.cir.88.5.2277. [DOI] [PubMed] [Google Scholar]
  30. Konstam M. A., Rousseau M. F., Kronenberg M. W., Udelson J. E., Melin J., Stewart D., Dolan N., Edens T. R., Ahn S., Kinan D. Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dysfunction in patients with heart failure. SOLVD Investigators. Circulation. 1992 Aug;86(2):431–438. doi: 10.1161/01.cir.86.2.431. [DOI] [PubMed] [Google Scholar]
  31. Lamas G. A., Vaughan D. E., Parisi A. F., Pfeffer M. A. Effects of left ventricular shape and captopril therapy on exercise capacity after anterior wall acute myocardial infarction. Am J Cardiol. 1989 May 15;63(17):1167–1173. doi: 10.1016/0002-9149(89)90173-2. [DOI] [PubMed] [Google Scholar]
  32. Lee R. M., Berecek K. H., Tsoporis J., McKenzie R., Triggle C. R. Prevention of hypertension and vascular changes by captopril treatment. Hypertension. 1991 Feb;17(2):141–150. doi: 10.1161/01.hyp.17.2.141. [DOI] [PubMed] [Google Scholar]
  33. Mannisi J. A., Weisman H. F., Bush D. E., Dudeck P., Healy B. Steroid administration after myocardial infarction promotes early infarct expansion. A study in the rat. J Clin Invest. 1987 May;79(5):1431–1439. doi: 10.1172/JCI112971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Newman T. J., Maskin C. S., Dennick L. G., Meyer J. H., Hallows B. G., Cooper W. H. Effects of captopril on survival in patients with heart failure. Am J Med. 1988 Mar 11;84(3A):140–144. doi: 10.1016/0002-9343(88)90221-5. [DOI] [PubMed] [Google Scholar]
  35. Pfeffer M. A., Braunwald E., Moyé L. A., Basta L., Brown E. J., Jr, Cuddy T. E., Davis B. R., Geltman E. M., Goldman S., Flaker G. C. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators. N Engl J Med. 1992 Sep 3;327(10):669–677. doi: 10.1056/NEJM199209033271001. [DOI] [PubMed] [Google Scholar]
  36. Pfeffer M. A., Lamas G. A., Vaughan D. E., Parisi A. F., Braunwald E. Effect of captopril on progressive ventricular dilatation after anterior myocardial infarction. N Engl J Med. 1988 Jul 14;319(2):80–86. doi: 10.1056/NEJM198807143190204. [DOI] [PubMed] [Google Scholar]
  37. Pirolo J. S., Hutchins G. M., Moore G. W. Infarct expansion: pathologic analysis of 204 patients with a single myocardial infarct. J Am Coll Cardiol. 1986 Feb;7(2):349–354. doi: 10.1016/s0735-1097(86)80504-6. [DOI] [PubMed] [Google Scholar]
  38. Ray S. G., Pye M., Oldroyd K. G., Christie J., Connelly D. T., Northridge D. B., Ford I., Morton J. J., Dargie H. J., Cobbe S. M. Early treatment with captopril after acute myocardial infarction. Br Heart J. 1993 Mar;69(3):215–222. doi: 10.1136/hrt.69.3.215. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Rumberger J. A., Behrenbeck T., Breen J. R., Reed J. E., Gersh B. J. Nonparallel changes in global left ventricular chamber volume and muscle mass during the first year after transmural myocardial infarction in humans. J Am Coll Cardiol. 1993 Mar 1;21(3):673–682. doi: 10.1016/0735-1097(93)90100-f. [DOI] [PubMed] [Google Scholar]
  40. Sharpe N., Murphy J., Smith H., Hannan S. Treatment of patients with symptomless left ventricular dysfunction after myocardial infarction. Lancet. 1988 Feb 6;1(8580):255–259. doi: 10.1016/s0140-6736(88)90347-9. [DOI] [PubMed] [Google Scholar]
  41. Sharpe N., Smith H., Murphy J., Greaves S., Hart H., Gamble G. Early prevention of left ventricular dysfunction after myocardial infarction with angiotensin-converting-enzyme inhibition. Lancet. 1991 Apr 13;337(8746):872–876. doi: 10.1016/0140-6736(91)90202-z. [DOI] [PubMed] [Google Scholar]
  42. Waagstein F., Bristow M. R., Swedberg K., Camerini F., Fowler M. B., Silver M. A., Gilbert E. M., Johnson M. R., Goss F. G., Hjalmarson A. Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy. Metoprolol in Dilated Cardiomyopathy (MDC) Trial Study Group. Lancet. 1993 Dec 11;342(8885):1441–1446. doi: 10.1016/0140-6736(93)92930-r. [DOI] [PubMed] [Google Scholar]
  43. Weber K. T., Brilla C. G., Janicki J. S. Myocardial fibrosis: functional significance and regulatory factors. Cardiovasc Res. 1993 Mar;27(3):341–348. doi: 10.1093/cvr/27.3.341. [DOI] [PubMed] [Google Scholar]
  44. Webster M. W., Fitzpatrick M. A., Nicholls M. G., Ikram H., Wells J. E. Effect of enalapril on ventricular arrhythmias in congestive heart failure. Am J Cardiol. 1985 Sep 15;56(8):566–569. doi: 10.1016/0002-9149(85)91186-5. [DOI] [PubMed] [Google Scholar]
  45. Weisman H. F., Bush D. E., Mannisi J. A., Weisfeldt M. L., Healy B. Cellular mechanisms of myocardial infarct expansion. Circulation. 1988 Jul;78(1):186–201. doi: 10.1161/01.cir.78.1.186. [DOI] [PubMed] [Google Scholar]
  46. White H. D., Norris R. M., Brown M. A., Brandt P. W., Whitlock R. M., Wild C. J. Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction. Circulation. 1987 Jul;76(1):44–51. doi: 10.1161/01.cir.76.1.44. [DOI] [PubMed] [Google Scholar]
  47. White H. D., Norris R. M., Brown M. A., Takayama M., Maslowski A., Bass N. M., Ormiston J. A., Whitlock T. Effect of intravenous streptokinase on left ventricular function and early survival after acute myocardial infarction. N Engl J Med. 1987 Oct 1;317(14):850–855. doi: 10.1056/NEJM198710013171402. [DOI] [PubMed] [Google Scholar]
  48. Woods K. L., Fletcher S., Roffe C., Haider Y. Intravenous magnesium sulphate in suspected acute myocardial infarction: results of the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2) Lancet. 1992 Jun 27;339(8809):1553–1558. doi: 10.1016/0140-6736(92)91828-v. [DOI] [PubMed] [Google Scholar]
  49. Yusuf S., Pepine C. J., Garces C., Pouleur H., Salem D., Kostis J., Benedict C., Rousseau M., Bourassa M., Pitt B. Effect of enalapril on myocardial infarction and unstable angina in patients with low ejection fractions. Lancet. 1992 Nov 14;340(8829):1173–1178. doi: 10.1016/0140-6736(92)92889-n. [DOI] [PubMed] [Google Scholar]
  50. Zelis R., Mason D. T., Braunwald E. A comparison of the effects of vasodilator stimuli on peripheral resistance vessels in normal subjects and in patients with congestive heart failure. J Clin Invest. 1968 Apr;47(4):960–970. doi: 10.1172/JCI105788. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Ziskind A. A., Pearce A. C., Lemmon C. C., Burstein S., Gimple L. W., Herrmann H. C., McKay R., Block P. C., Waldman H., Palacios I. F. Percutaneous balloon pericardiotomy for the treatment of cardiac tamponade and large pericardial effusions: description of technique and report of the first 50 cases. J Am Coll Cardiol. 1993 Jan;21(1):1–5. doi: 10.1016/0735-1097(93)90710-i. [DOI] [PubMed] [Google Scholar]
  52. van Gilst W. H., de Graeff P. A., Wesseling H., de Langen C. D. Reduction of reperfusion arrhythmias in the ischemic isolated rat heart by angiotensin converting enzyme inhibitors: a comparison of captopril, enalapril, and HOE 498. J Cardiovasc Pharmacol. 1986 Jul-Aug;8(4):722–728. [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES