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. 1989 Oct;151(4):410–413.

Strongyloidiasis associated with human T-cell lymphotropic virus type I infection in a nonendemic area.

A C Dixon, E T Yanagihara, D W Kwock, J M Nakamura
PMCID: PMC1026828  PMID: 2588581

Abstract

Concomitant strongyloidiasis and human T-cell lymphotropic virus type I (HTLV-I) infection has been reported from areas in Japan where both organisms are endemic. We present four cases of concomitant infection with these organisms from an area that is not endemic for Strongyloides stercoralis. Three of the four patients had adult T-cell leukemia, an aggressive neoplasm resulting from HTLV-I infection, while the other was an asymptomatic carrier of HTLV-I. Three of the patients had spent their childhoods in an endemic location for both organisms, suggesting an initial infection at that time. Three patients were symptomatic from their parasitism. We conclude that strongyloidiasis may be found in nonendemic locations in patients with either adult T-cell leukemia or an asymptomatic HTLV-I carrier state. Whether infestation with this parasite contributes to the leukemogenesis of HTLV-I, as postulated by others, cannot at this time be determined.

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Selected References

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  1. Biggar R. J., Gigase P. L., Melbye M., Kestens L., Sarin P. S., Bodner A. J., Demedts P., Stevens W. J., Paluku L., Delacollette C. ELISA HTLV retrovirus antibody reactivity associated with malaria and immune complexes in healthy Africans. Lancet. 1985 Sep 7;2(8454):520–523. doi: 10.1016/s0140-6736(85)90461-1. [DOI] [PubMed] [Google Scholar]
  2. Bunn P. A., Jr, Schechter G. P., Jaffe E., Blayney D., Young R. C., Matthews M. J., Blattner W., Broder S., Robert-Guroff M., Gallo R. C. Clinical course of retrovirus-associated adult T-cell lymphoma in the United States. N Engl J Med. 1983 Aug 4;309(5):257–264. doi: 10.1056/NEJM198308043090501. [DOI] [PubMed] [Google Scholar]
  3. Dixon A. C., Kwock D. W., Nakamura J. M., Yanagihara E. T., Saiki S. M., Bodner A. J., Alexander S. S. Thrombotic thrombocytopenic purpura and human T-lymphotrophic virus, type 1 (HTLV-1) Ann Intern Med. 1989 Jan 1;110(1):93–94. doi: 10.7326/0003-4819-110-1-93. [DOI] [PubMed] [Google Scholar]
  4. Gessain A., Barin F., Vernant J. C., Gout O., Maurs L., Calender A., de Thé G. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet. 1985 Aug 24;2(8452):407–410. doi: 10.1016/s0140-6736(85)92734-5. [DOI] [PubMed] [Google Scholar]
  5. Gill G. V., Bell D. R., Fifield R. Lack of immunoglobulin E response to longstanding strongyloidiasis. Clin Exp Immunol. 1979 Aug;37(2):292–294. [PMC free article] [PubMed] [Google Scholar]
  6. Gill G. V., Bell D. R. Strongyloides stercoralis infection in former Far East prisoners of war. Br Med J. 1979 Sep 8;2(6190):572–574. doi: 10.1136/bmj.2.6190.572. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Igra-Siegman Y., Kapila R., Sen P., Kaminski Z. C., Louria D. B. Syndrome of hyperinfection with Strongyloides stercoralis. Rev Infect Dis. 1981 May-Jun;3(3):397–407. doi: 10.1093/clinids/3.3.397. [DOI] [PubMed] [Google Scholar]
  8. Ito Y. The epidemiology of human T-cell leukemia/lymphoma virus. Curr Top Microbiol Immunol. 1985;115:99–112. doi: 10.1007/978-3-642-70113-9_7. [DOI] [PubMed] [Google Scholar]
  9. Kawano F., Yamaguchi K., Nishimura H., Tsuda H., Takatsuki K. Variation in the clinical courses of adult T-cell leukemia. Cancer. 1985 Feb 15;55(4):851–856. doi: 10.1002/1097-0142(19850215)55:4<851::aid-cncr2820550424>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  10. Kaye D. The spectrum of strongyloidiasis. Hosp Pract (Off Ed) 1988 Oct 15;23(10):111-5, 118-9, 125-6. doi: 10.1080/21548331.1988.11703559. [DOI] [PubMed] [Google Scholar]
  11. Komuro A., Hayami M., Fujii H., Miyahara S., Hirayama M. Vertical transmission of adult T-cell leukaemia virus. Lancet. 1983 Jan 29;1(8318):240–240. doi: 10.1016/s0140-6736(83)92613-2. [DOI] [PubMed] [Google Scholar]
  12. Milder J. E., Walzer P. D., Kilgore G., Rutherford I., Klein M. Clinical features of Strongyloides stercoralis infection in an endemic area of the United States. Gastroenterology. 1981 Jun;80(6):1481–1488. [PubMed] [Google Scholar]
  13. Nakada K., Kohakura M., Komoda H., Hinuma Y. High incidence of HTLV antibody in carriers of Strongyloides stercoralis. Lancet. 1984 Mar 17;1(8377):633–633. doi: 10.1016/s0140-6736(84)91030-4. [DOI] [PubMed] [Google Scholar]
  14. Nakada K., Yamaguchi K., Furugen S., Nakasone T., Nakasone K., Oshiro Y., Kohakura M., Hinuma Y., Seiki M., Yoshida M. Monoclonal integration of HTLV-I proviral DNA in patients with strongyloidiasis. Int J Cancer. 1987 Aug 15;40(2):145–148. doi: 10.1002/ijc.2910400203. [DOI] [PubMed] [Google Scholar]
  15. Osame M., Usuku K., Izumo S., Ijichi N., Amitani H., Igata A., Matsumoto M., Tara M. HTLV-I associated myelopathy, a new clinical entity. Lancet. 1986 May 3;1(8488):1031–1032. doi: 10.1016/s0140-6736(86)91298-5. [DOI] [PubMed] [Google Scholar]
  16. Poiesz B. J., Ruscetti F. W., Reitz M. S., Kalyanaraman V. S., Gallo R. C. Isolation of a new type C retrovirus (HTLV) in primary uncultured cells of a patient with Sézary T-cell leukaemia. Nature. 1981 Nov 19;294(5838):268–271. doi: 10.1038/294268a0. [DOI] [PubMed] [Google Scholar]
  17. Purtilo D. T., Meyers W. M., Connor D. H. Fatal strongyloidiasis in immunosuppressed patients. Am J Med. 1974 Apr;56(4):488–493. doi: 10.1016/0002-9343(74)90481-1. [DOI] [PubMed] [Google Scholar]
  18. Robert-Guroff M., Weiss S. H., Giron J. A., Jennings A. M., Ginzburg H. M., Margolis I. B., Blattner W. A., Gallo R. C. Prevalence of antibodies to HTLV-I, -II, and -III in intravenous drug abusers from an AIDS endemic region. JAMA. 1986 Jun 13;255(22):3133–3137. [PubMed] [Google Scholar]
  19. Rosenblatt J. D., Chen I. S., Wachsman W. Infection with HTLV-I and HTLV-II: evolving concepts. Semin Hematol. 1988 Jul;25(3):230–246. [PubMed] [Google Scholar]
  20. Scowden E. B., Schaffner W., Stone W. J. Overwhelming strongyloidiasis: an unappreciated opportunistic infection. Medicine (Baltimore) 1978 Nov;57(6):527–544. [PubMed] [Google Scholar]
  21. Stemmermann G. N. Strongyloidiasis in migrants. Pathological and clinical considerations. Gastroenterology. 1967 Jul;53(1):59–70. [PubMed] [Google Scholar]
  22. Tajima K., Fujita K., Tsukidate S., Oda T., Tominaga S., Suchi T., Hinuma Y. Seroepidemiological studies on the effects of filarial parasites on infestation of adult T-cell leukemia virus in the Goto Islands, Japan. Gan. 1983 Apr;74(2):188–191. [PubMed] [Google Scholar]
  23. Tajima K., Tominaga S., Suchi T., Kawagoe T., Komoda H., Hinuma Y., Oda T., Fujita K. Epidemiological analysis of the distribution of antibody to adult T-cell leukemia-virus-associated antigen: possible horizontal transmission of adult T-cell leukemia virus. Gan. 1982 Dec;73(6):893–901. [PubMed] [Google Scholar]
  24. Vernant J. C., Maurs L., Gessain A., Barin F., Gout O., Delaporte J. M., Sanhadji K., Buisson G., de-Thé G. Endemic tropical spastic paraparesis associated with human T-lymphotropic virus type I: a clinical and seroepidemiological study of 25 cases. Ann Neurol. 1987 Feb;21(2):123–130. doi: 10.1002/ana.410210204. [DOI] [PubMed] [Google Scholar]
  25. Yamaguchi K., Matutes E., Catovsky D., Galton D. A., Nakada K., Takatsuki K. Strongyloides stercoralis as candidate co-factor for HTLV-I-induced leukaemogenesis. Lancet. 1987 Jul 11;2(8550):94–95. doi: 10.1016/s0140-6736(87)92752-8. [DOI] [PubMed] [Google Scholar]
  26. Yanagihara E. T., Nakamura J., Kimura L., Oishi N. Retrovirus-associated adult T-cell leukemia-lymphoma: an epidemiologic study of five cases among Hawaii-born offspring of migrant Japanese. Hematol Oncol. 1989 Mar-Apr;7(2):181–188. doi: 10.1002/hon.2900070210. [DOI] [PubMed] [Google Scholar]
  27. Yoshioka R., Yamaguchi K., Yoshinaga T., Takatsuki K. Pulmonary complications in patients with adult T-cell leukemia. Cancer. 1985 May 15;55(10):2491–2494. doi: 10.1002/1097-0142(19850515)55:10<2491::aid-cncr2820551030>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]

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