Abstract
In a crossover study designed to judge the efficacy of the topical polymeric starch iodophore, cadexomer iodine, in accelerating the healing of venous stasis ulcers, 75 patients were prospectively randomly assigned to receive either cadexomer iodine or standard treatment. The control treatment consisted of a standard saline wet-to-dry compressive dressing. The patients improved with either treatment: ulcers healed more than twice as rapidly using cadexomer iodine (n = 38) as with standard therapy (n = 37) (P = .0025). Ulcers treated with cadexomer iodine showed trends toward less pain, exudate, pus, and debris, and a more rapid development of granulation tissue. Twelve patients crossed over from control treatment to the use of cadexomer iodine because of a failure to heal, but no patients switched to control therapy from the use of cadexomer iodine (P = .01). Except for occasional mild local burning in wounds treated with cadexomer iodine, no adverse effects were noted with either regimen.
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Selected References
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- Coon W. W., Willis P. W., 3rd, Keller J. B. Venous thromboembolism and other venous disease in the Tecumseh community health study. Circulation. 1973 Oct;48(4):839–846. doi: 10.1161/01.cir.48.4.839. [DOI] [PubMed] [Google Scholar]
- Jacobsson S., Rothman U., Arturson G., Ganrot K., Haeger K., Juhlin I. A new principle for the cleansing of infected wounds. Scand J Plast Reconstr Surg. 1976;10(1):65–72. [PubMed] [Google Scholar]
- Krizek T. J., Robson M. C. Evolution of quantitative bacteriology in wound management. Am J Surg. 1975 Nov;130(5):579–584. doi: 10.1016/0002-9610(75)90516-4. [DOI] [PubMed] [Google Scholar]
- Ormiston M. C., Seymour M. T., Venn G. E., Cohen R. I., Fox J. A. Controlled trial of Iodosorb in chronic venous ulcers. Br Med J (Clin Res Ed) 1985 Aug 3;291(6491):308–310. doi: 10.1136/bmj.291.6491.308. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Robson M. C., Heggers J. P. Surgical infection. II. The beta-hemolytic streptococcus. J Surg Res. 1969 May;9(5):289–292. doi: 10.1016/0022-4804(69)90068-7. [DOI] [PubMed] [Google Scholar]
- Ruckley C. V., Dale J. J., Callam M. J., Harper D. R. Causes of chronic leg ulcer. Lancet. 1982 Sep 11;2(8298):615–616. doi: 10.1016/s0140-6736(82)90699-7. [DOI] [PubMed] [Google Scholar]
- Skog E., Arnesjö B., Troëng T., Gjöres J. E., Bergljung L., Gundersen J., Hallbök T., Hessman Y., Hillström L., Månsson T. A randomized trial comparing cadexomer iodine and standard treatment in the out-patient management of chronic venous ulcers. Br J Dermatol. 1983 Jul;109(1):77–83. doi: 10.1111/j.1365-2133.1983.tb03995.x. [DOI] [PubMed] [Google Scholar]