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. 1984 Feb;47(2):134–140. doi: 10.1136/jnnp.47.2.134

A retrospective study of Creutzfeldt-Jakob disease in England and Wales 1970-79. I: Clinical features.

R G Will, W B Matthews
PMCID: PMC1027681  PMID: 6368752

Abstract

A comprehensive search yielded 121 confirmed cases of Creutzfeldt-Jakob disease who died in England and Wales in the decade 1970-79, and 31 probable cases. The clinical features and the results of investigation are described. Three subgroups of patients were distinguished by clinical characteristics and contrasting course.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beck E., Daniel P. M., Davey A. J., Gajdusek D. C., Gibbs C. J., Jr The pathogenesis of transmissible spongiform encephalopathy: an ultrastructural study. Brain. 1982 Dec;105(Pt 4):755–786. doi: 10.1093/brain/105.4.755. [DOI] [PubMed] [Google Scholar]
  2. Brown P., Cathala F., Gajdusek D. C. Creutzfeldt-Jakob disease in France: III. Epidemiological study of 170 patients dying during the decade 1968--1977. Ann Neurol. 1979 Nov;6(5):438–446. doi: 10.1002/ana.410060511. [DOI] [PubMed] [Google Scholar]
  3. Brown P., Cathala F., Sadowsky D., Gajdusek D. C. Creutzfeldt-Jakob disease in France: II. Clinical characteristics of 124 consecutive verified cases during the decade 1968--1977. Ann Neurol. 1979 Nov;6(5):430–437. doi: 10.1002/ana.410060510. [DOI] [PubMed] [Google Scholar]
  4. Galvez S., Masters C., Gajdusek C. Descriptive epidemiology of Creutzfeldt-Jakob disease in Chile. Arch Neurol. 1980 Jan;37(1):11–14. doi: 10.1001/archneur.1980.00500500041004. [DOI] [PubMed] [Google Scholar]
  5. Gibbs C. J., Jr, Gajdusek D. C., Asher D. M., Alpers M. P., Beck E., Daniel P. M., Matthews W. B. Creutzfeldt-Jakob disease (spongiform encephalopathy): transmission to the chimpanzee. Science. 1968 Jul 26;161(3839):388–389. doi: 10.1126/science.161.3839.388. [DOI] [PubMed] [Google Scholar]
  6. Gálvez S., Farcas A., Monari M. Cerebrospinal fluid and serum immunoglobulins and C3 in Creutzfeldt-Jakob disease. Neurology. 1979 Dec;29(12):1610–1612. doi: 10.1212/wnl.29.12.1610. [DOI] [PubMed] [Google Scholar]
  7. Manuelidis E. E. Transmission of Creutzfeldt-Jakob disease from man to the guinea pig. Science. 1975 Nov 7;190(4214):571–572. [PubMed] [Google Scholar]
  8. Masters C. L., Gajdusek D. C., Gibbs C. J., Jr Creutzfeldt-Jakob disease virus isolations from the Gerstmann-Sträussler syndrome with an analysis of the various forms of amyloid plaque deposition in the virus-induced spongiform encephalopathies. Brain. 1981 Sep;104(3):559–588. doi: 10.1093/brain/104.3.559. [DOI] [PubMed] [Google Scholar]
  9. Masters C. L., Harris J. O., Gajdusek D. C., Gibbs C. J., Jr, Bernoulli C., Asher D. M. Creutzfeldt-Jakob disease: patterns of worldwide occurrence and the significance of familial and sporadic clustering. Ann Neurol. 1979 Feb;5(2):177–188. doi: 10.1002/ana.410050212. [DOI] [PubMed] [Google Scholar]
  10. Masters C. L., Richardson E. P., Jr Subacute spongiform encephalopathy (Creutzfeldt-Jakob disease). The nature and progression of spongiform change. Brain. 1978 Jun;101(2):333–344. doi: 10.1093/brain/101.2.333. [DOI] [PubMed] [Google Scholar]
  11. Matthews W. B. Epidemiology of Creutzfeldt-Jakob disease in England and Wales. J Neurol Neurosurg Psychiatry. 1975 Mar;38(3):210–213. doi: 10.1136/jnnp.38.3.210. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Neugut R. H., Neugut A. I., Kahana E., Stein Z., Alter M. Creutzfeldt-Jakob disease: familial clustering among Libyan-born Israelis. Neurology. 1979 Feb;29(2):225–231. doi: 10.1212/wnl.29.2.225. [DOI] [PubMed] [Google Scholar]
  13. Salazar A. M., Masters C. L., Gajdusek D. C., Gibbs C. J., Jr Syndromes of amyotrophic lateral sclerosis and dementia: relation to transmissible Creutzfeldt-Jakob disease. Ann Neurol. 1983 Jul;14(1):17–26. doi: 10.1002/ana.410140104. [DOI] [PubMed] [Google Scholar]
  14. Sanders W. L. Creutzfeldt-Jakob disease treated with amantadine. J Neurol Neurosurg Psychiatry. 1979 Oct;42(10):960–961. doi: 10.1136/jnnp.42.10.960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Watson C. P. Clinical similarity of Alzheimer and Creutzfeldt-Jakob disease. Ann Neurol. 1979 Oct;6(4):368–369. doi: 10.1002/ana.410060415. [DOI] [PubMed] [Google Scholar]
  16. Will R. G., Matthews W. B. Evidence for case-to-case transmission of Creutzfeldt-Jakob disease. J Neurol Neurosurg Psychiatry. 1982 Mar;45(3):235–238. doi: 10.1136/jnnp.45.3.235. [DOI] [PMC free article] [PubMed] [Google Scholar]

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