Abstract
Serum phenytoin concentrations were monitored prospectively in 26 patients with previously untreated partial epilepsy, during monotherapy with phenytoin. Only six remained entirely seizure-free, although only four experienced further tonic-clonic seizures. There was no correlation between serum phenytoin concentrations and freedom from partial seizures in those patients in whom such seizures recurred. There did appear to be a correlation between serum phenytoin concentration and freedom from tonic-clonic seizures.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BUCHTHAL F., SVENSMARK O., SCHILLER P. J. Clinical and electroencephalographic correlations with serum levels of diphenylhydanotin. Arch Neurol. 1960 Jun;2:624–630. doi: 10.1001/archneur.1960.03840120030004. [DOI] [PubMed] [Google Scholar]
- Borofsky L. G., Louis S., Kutt H. Diphenylhydantoin in children. Pharmacology and efficacy. Neurology. 1973 Sep;23(9):967–972. doi: 10.1212/wnl.23.9.967. [DOI] [PubMed] [Google Scholar]
- Gannaway D. J., Mawer G. E. Serum phenytoin concentration and clinical response in patients with epilepsy. Br J Clin Pharmacol. 1981 Dec;12(6):833–839. doi: 10.1111/j.1365-2125.1981.tb01316.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haerer A. F., Grace J. B. Studies of anticonvulsant levels in epileptics. I. Serum diphenylhydantoin concentrations in a group of medically indigent outpatients. Acta Neurol Scand. 1969;45(1):18–31. [PubMed] [Google Scholar]
- Lund L. Anticonvulsant effect of diphenylhydantoin relative to plasma levels. A prospective three-year study in ambulant patients with generalized epileptic seizures. Arch Neurol. 1974 Nov;31(5):289–294. doi: 10.1001/archneur.1974.00490410037002. [DOI] [PubMed] [Google Scholar]
- Reynolds E. H. Serum levels of anticonvulsant drugs. Interpretation and clinical value. Pharmacol Ther. 1980;8(2):217–235. doi: 10.1016/0163-7258(80)90047-9. [DOI] [PubMed] [Google Scholar]
- Reynolds E. H., Shorvon S. D., Galbraith A. W., Chadwick D., Dellaportas C. I., Vydelingum L. Phenytoin monotherapy for epilepsy: a long-term prospective study, assisted by serum level monitoring, in previously untreated patients. Epilepsia. 1981 Aug;22(4):475–488. doi: 10.1111/j.1528-1157.1981.tb06158.x. [DOI] [PubMed] [Google Scholar]
- Shorvon S. D., Chadwick D., Galbraith A. W., Reynolds E. H. One drug for epilepsy. Br Med J. 1978 Feb 25;1(6111):474–476. doi: 10.1136/bmj.1.6111.474. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shorvon S. D., Reynolds E. H. Early prognosis of epilepsy. Br Med J (Clin Res Ed) 1982 Dec 11;285(6356):1699–1701. doi: 10.1136/bmj.285.6356.1699. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Strandjord R. E., Johannessen S. I. Single-drug therapy with carbamazepine in patients with epilepsy: serum levels and clinical effect. Epilepsia. 1980 Dec;21(6):655–652. doi: 10.1111/j.1528-1157.1980.tb04319.x. [DOI] [PubMed] [Google Scholar]
- Travers R. D., Reynolds E. H., Gallagher B. B. Variation in response to anticonvulsants in a group of epileptic patients. Arch Neurol. 1972 Jul;27(1):29–33. doi: 10.1001/archneur.1972.00490130031004. [DOI] [PubMed] [Google Scholar]
- Turnbull D. M., Rawlins M. D., Weightman D., Chadwick D. W. A comparison of phenytoin and valproate in previously untreated adult epileptic patients. J Neurol Neurosurg Psychiatry. 1982 Jan;45(1):55–59. doi: 10.1136/jnnp.45.1.55. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Turnbull D. M., Rawlins M. D., Weightman D., Chadwick D. W. Plasma concentrations of sodium valproate: their clinical value. Ann Neurol. 1983 Jul;14(1):38–42. doi: 10.1002/ana.410140107. [DOI] [PubMed] [Google Scholar]