Skip to main content
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1984 Jul;47(7):724–729. doi: 10.1136/jnnp.47.7.724

Cerebrospinal fluid enolase in stroke.

E Hay, J A Royds, G A Davies-Jones, N A Lewtas, W R Timperley, C B Taylor
PMCID: PMC1027902  PMID: 6747647

Abstract

This study relates the level of alpha and gamma enolase in cerebrospinal fluid sampled within 4 days of a stroke to the volume of the cerebral infarct measured on the CT image and to the clinical outcome of the patient. Twenty-eight patients were studied, two with transient ischaemic attacks and 26 with completed stroke due to infarction. The cerebrospinal fluid enolase was raised in the two patients with transient ischaemic attacks and 23 with completed stroke. There was a positive correlation between the volume of the infarct and the level of cerebrospinal fluid alpha and gamma enolase. A high cerebrospinal fluid enolase was always associated with a poor prognosis.

Full text

PDF
726

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alcalá H., Gado M., Torack R. M. The effect of size, histologic elements, and water content on the visualization of cerebral infarcts. Arch Neurol. 1978 Jan;35(1):1–7. doi: 10.1001/archneur.1978.00500250005001. [DOI] [PubMed] [Google Scholar]
  2. Bolton A. E., Hunter W. M. The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Biochem J. 1973 Jul;133(3):529–539. doi: 10.1042/bj1330529. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Campbell I. C., Marangos P. J., Parma A., Garrick N. A., Murphy D. L. Localization of monoamine oxidases A and B in primate brains relative to neuron-specific and non-neuronal enolases. Neurochem Res. 1982 Jun;7(6):657–666. doi: 10.1007/BF00965519. [DOI] [PubMed] [Google Scholar]
  4. Dubo H., Park D. C., Pennington R. J., Kalbag R. M., Walton J. N. Serum-creatine-kinase in cases of stroke, head injury, and meningitis. Lancet. 1967 Oct 7;2(7519):743–748. doi: 10.1016/s0140-6736(67)91946-0. [DOI] [PubMed] [Google Scholar]
  5. Eisen A. A., Sherwin A. L. Serum creatine phosphokinase activity in cerebral infarction. Neurology. 1968 Mar;18(3):263–268. doi: 10.1212/wnl.18.3.263. [DOI] [PubMed] [Google Scholar]
  6. FLEISHER G. A., WAKIM K. G., GOLDSTEIN N. P. Glutamic-oxalacetic transaminase and lactic dehydrogenase in serum and cerebrospinal fluid of patients with neurologic disorders. Proc Staff Meet Mayo Clin. 1957 Apr 17;32(8):188–197. [PubMed] [Google Scholar]
  7. Jennett B., Bond M. Assessment of outcome after severe brain damage. Lancet. 1975 Mar 1;1(7905):480–484. doi: 10.1016/s0140-6736(75)92830-5. [DOI] [PubMed] [Google Scholar]
  8. Kotoku T., Kawakami H., Iwabuchi T., Sato T., Kutsuzawa T. Clinical significance of serum creatine phosphokinase activity in cerebrovascular diseases. Tohoku J Exp Med. 1971 Oct;105(2):167–175. doi: 10.1620/tjem.105.167. [DOI] [PubMed] [Google Scholar]
  9. Liliequist B., Wirell S. Quantitative estimation of tumor volume on computer assisted tomography. J Comput Assist Tomogr. 1978 Jul;2(3):300–302. doi: 10.1097/00004728-197807000-00011. [DOI] [PubMed] [Google Scholar]
  10. Norris J. W., Hachinski V. C., Myers M. G., Callow J., Wong T., Moore R. W. Serum cardiac enzymes in stroke. Stroke. 1979 Sep-Oct;10(5):548–553. doi: 10.1161/01.str.10.5.548. [DOI] [PubMed] [Google Scholar]
  11. Royds J. A., Parsons M. A., Taylor C. B., Timperley W. R. Enolase isoenzyme distribution in the human brain and its tumours. J Pathol. 1982 May;137(1):37–49. doi: 10.1002/path.1711370105. [DOI] [PubMed] [Google Scholar]
  12. Royds J. A., Timperley W. R., Taylor C. B. Levels of enolase and other enzymes in the cerebrospinal fluid as indices of pathological change. J Neurol Neurosurg Psychiatry. 1981 Dec;44(12):1129–1135. doi: 10.1136/jnnp.44.12.1129. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Semba R., Kato K. Increased nervous system-specific enolases in rat plasma and cerebrospinal fluid in bilirubin encephalopathy detected by an enzyme immunoassay. J Neurochem. 1982 Aug;39(2):360–365. doi: 10.1111/j.1471-4159.1982.tb03956.x. [DOI] [PubMed] [Google Scholar]
  14. Somer H., Kaste M., Troupp H., Konttinen A. Brain creatine kinase in blood after acute brain injury. J Neurol Neurosurg Psychiatry. 1975 Jun;38(6):572–576. doi: 10.1136/jnnp.38.6.572. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Wolintz A. H., Jacobs L. D., Christoff N., Solomon M., Chernik N. Serum and cerebrospinal fluid enzymes in cerebrovascular disease. Creatine phosphokinase, aldolase, and lactic dehydrogenase. Arch Neurol. 1969 Jan;20(1):54–61. doi: 10.1001/archneur.1969.00480070064007. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES