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. 1985 Dec;48(12):1240–1245. doi: 10.1136/jnnp.48.12.1240

Respiration and sleep in Parkinson's disease.

M C Apps, P C Sheaff, D A Ingram, C Kennard, D W Empey
PMCID: PMC1028608  PMID: 4086999

Abstract

Sleep and respiration during sleep were studied in patients with idiopathic Parkinson's disease, patients with Parkinsonism with autonomic disturbance, and normal age and sex matched controls. Patients with idiopathic Parkinson's disease showed significantly reduced REM sleep, and more frequent and prolonged waking throughout the night. Hypoventilation and sleep apnoea did not occur in the idiopathic Parkinson's disease or normal groups, but respiration was disorganised with frequent central and obstructive apnoeas in the autonomic disturbance group. Respiratory rate during non rapid eye movement sleep was similar in the idiopathic Parkinson's disease and normal groups, but patients with idiopathic Parkinson's disease showed tachypnoea awake and during REM sleep.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barbeau A. L-dopa therapy in Parkinson's disease: a critical review of nine years' experience. Can Med Assoc J. 1969 Dec 27;101(13):59–68. [PMC free article] [PubMed] [Google Scholar]
  2. Bergonzi P., Chiurulla C., Cianchetti C., Tempesta E. Clinical pharmacology as an approach to the study of biochemical sleep mechanisms: the action of L-dopa. Confin Neurol. 1974;36(1):5–22. doi: 10.1159/000102780. [DOI] [PubMed] [Google Scholar]
  3. Calne D. B., Stern G. M., Laurence D. R., Sharkey J., Armitage P. L-dopa in postencephalitic parkinsonism. Lancet. 1969 Apr 12;1(7598):744–746. doi: 10.1016/s0140-6736(69)91751-6. [DOI] [PubMed] [Google Scholar]
  4. Da Costa J. L. Chronic hypoventilation due to diminished sensitivity of the respiratory centre associated with Parkinsonism. Med J Aust. 1972 Feb 19;1(8):373–376. doi: 10.5694/j.1326-5377.1972.tb46842.x. [DOI] [PubMed] [Google Scholar]
  5. Dement W. C., Miles L. E., Carskadon M. A. "White paper" on sleep and aging. J Am Geriatr Soc. 1982 Jan;30(1):25–50. doi: 10.1111/j.1532-5415.1982.tb03700.x. [DOI] [PubMed] [Google Scholar]
  6. Friedman A. Sleep pattern in Parkinson's disease. Acta Med Pol. 1980;21(2):193–199. [PubMed] [Google Scholar]
  7. GARLIND T., LINDERHOLM H. Hypoventilation syndrome in a case of chronic epidemic encephalitis. Acta Med Scand. 1958 Nov 27;162(5):333–349. doi: 10.1111/j.0954-6820.1958.tb01780.x. [DOI] [PubMed] [Google Scholar]
  8. GREENFIELD J. G., BOSANQUET F. D. The brain-stem lesions in Parkinsonism. J Neurol Neurosurg Psychiatry. 1953 Nov;16(4):213–226. doi: 10.1136/jnnp.16.4.213. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. GREWEL F. Dysarthria in post-encephalitic parkinsonism. Acta Psychiatr Neurol Scand. 1957;32(4):440–449. doi: 10.1111/j.1600-0447.1957.tb07555.x. [DOI] [PubMed] [Google Scholar]
  10. Granerus A. K., Jagenburg R., Nilsson N. J., Svanborg A. Respiratory disturbance during L-dopa treatment of Parkinson's syndrome. Acta Med Scand. 1974 Jan-Feb;195(1-2):39–43. doi: 10.1111/j.0954-6820.1974.tb08094.x. [DOI] [PubMed] [Google Scholar]
  11. Gulleminault C., Lehrman A. T., Forno L., Dement W. C. Sleep apnoea syndrome: states of sleep and autonomic dysfunction. J Neurol Neurosurg Psychiatry. 1977 Jul;40(7):718–725. doi: 10.1136/jnnp.40.7.718. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Jouvet M. The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle. Ergeb Physiol. 1972;64:166–307. doi: 10.1007/3-540-05462-6_2. [DOI] [PubMed] [Google Scholar]
  13. Kales A., Ansel R. D., Markham C. H., Scharf M. B., Tan T. L. Sleep in patients with Parkinson's disease and normal subjects prior to and following levodopa administration. Clin Pharmacol Ther. 1971 Mar-Apr;12(2):397–406. doi: 10.1002/cpt1971122part2397. [DOI] [PubMed] [Google Scholar]
  14. Kendel K., Beck U., Wita C., Hohneck E., Zimmermann H. Der Eingluss von L-DOPA auf den Nachtschlaf bei Patienten mit Parkinson-Syndrom. Arch Psychiatr Nervenkr (1970) 1972;216(1):82–100. doi: 10.1007/BF00342499. [DOI] [PubMed] [Google Scholar]
  15. Kim R. The chronic residual respiratory disorder in post-encephalitis Parkinsonism. J Neurol Neurosurg Psychiatry. 1968 Aug;31(4):393–398. doi: 10.1136/jnnp.31.4.393. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. McNicholas W. T., Rutherford R., Grossman R., Moldofsky H., Zamel N., Phillipson E. A. Abnormal respiratory pattern generation during sleep in patients with autonomic dysfunction. Am Rev Respir Dis. 1983 Sep;128(3):429–433. doi: 10.1164/arrd.1983.128.3.429. [DOI] [PubMed] [Google Scholar]
  17. Mouret J. Differences in sleep in patients with Parkinson's disease. Electroencephalogr Clin Neurophysiol. 1975 Jun;38(6):653–657. doi: 10.1016/0013-4694(75)90168-6. [DOI] [PubMed] [Google Scholar]
  18. Neu H. C., Connolly J. J., Jr, Schwertley F. W., Ladwig H. A., Brody A. W. Obstructive respiratory dysfunction in parkinsonian patients. Am Rev Respir Dis. 1967 Jan;95(1):33–47. doi: 10.1164/arrd.1967.95.1.33. [DOI] [PubMed] [Google Scholar]
  19. Perry T. L., Bratty P. J., Hansen S., Kennedy J., Urquhart N., Dolman C. L. Hereditary mental depression and Parkinsonism with taurine deficiency. Arch Neurol. 1975 Feb;32(2):108–113. doi: 10.1001/archneur.1975.00490440058009. [DOI] [PubMed] [Google Scholar]
  20. Phillipson E. A. Regulation of breathing during sleep. Am Rev Respir Dis. 1977 Jun;115(6 Pt 2):217–224. doi: 10.1164/arrd.1977.115.S.217. [DOI] [PubMed] [Google Scholar]
  21. Purdy A., Hahn A., Barnett H. J., Bratty P., Ahmad D., Lloyd K. G., McGeer E. G., Perry T. L. Familial fatal Parkinsonism with alveolar hypoventilation and mental depression. Ann Neurol. 1979 Dec;6(6):523–531. doi: 10.1002/ana.410060611. [DOI] [PubMed] [Google Scholar]
  22. Rabey J., Vardi J., Glaubman H., Streifler M. EEG sleep study in parkinsonian patients under bromocryptine treatment. Eur Neurol. 1978;17(6):345–350. doi: 10.1159/000114973. [DOI] [PubMed] [Google Scholar]
  23. Sacks O. W., Kohl M., Schwartz W., Messeloff C. Side-effects of L-dopa in postencephalic parkinsonism. Lancet. 1970 May 9;1(7654):1006–1006. doi: 10.1016/s0140-6736(70)91137-2. [DOI] [PubMed] [Google Scholar]
  24. Schneider E., Maxion H., Ziegler B., Jacobi P. Das Schlafverhalten von Parkinsonkranken und seine Beeinflussung durch L-DOPA. J Neurol. 1974 Jun 27;207(2):95–108. doi: 10.1007/BF00594087. [DOI] [PubMed] [Google Scholar]
  25. Strieder D. J., Baker W. G., Baringer J. R., Kazemi H. Chronic hypoventilation of central origin. A case with encephalitis lethargica and Parkinson's syndrome. Am Rev Respir Dis. 1967 Sep;96(3):501–507. doi: 10.1164/arrd.1967.96.3.501. [DOI] [PubMed] [Google Scholar]
  26. Traczynska-Kubin D., Atzef E., Petre-Quadens O. Le sommeil dans la maladie de Parkinson. Acta Neurol Psychiatr Belg. 1969 Sep;69(9):727–733. [PubMed] [Google Scholar]
  27. Wein A., Golubev V., Yakhno N. Polygraphic analysis of sleep and wakefulness in patients with Parkinson's syndrome. Waking Sleeping. 1979 Jan;3(1):31–40. [PubMed] [Google Scholar]
  28. Weiner W. J., Goetz C. G., Nausieda P. A., Klawans H. L. Respiratory dyskinesias: extrapyramidal dysfunction and dyspnea. Ann Intern Med. 1978 Mar;88(3):327–331. doi: 10.7326/0003-4819-88-3-327. [DOI] [PubMed] [Google Scholar]
  29. Williams A., Hanson D., Calne D. B. Vocal cord paralysis in the Shy-Drager syndrome. J Neurol Neurosurg Psychiatry. 1979 Feb;42(2):151–153. doi: 10.1136/jnnp.42.2.151. [DOI] [PMC free article] [PubMed] [Google Scholar]

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