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. 1993 Jul;69(1 Spec No):37–39. doi: 10.1136/adc.69.1_spec_no.37

The effect of intravenous ranitidine on the intragastric pH of preterm infants receiving dexamethasone.

E J Kelly 1, S L Chatfield 1, K G Brownlee 1, P C Ng 1, S J Newell 1, P R Dear 1, J N Primrose 1
PMCID: PMC1029395  PMID: 8346951

Abstract

Gastric perforation is a catastrophic, albeit uncommon, side effect of steroid treatment for premature infants with bronchopulmonary dysplasia (BPD). A reduction of intragastric acidity may protect against peptic ulceration. The effect of different doses of ranitidine, given as intravenous infusions, on intragastric acidity in premature neonates was therefore examined. Ten consecutive, enterally starved, infants receiving dexamethasone (0.6 mg/kg) for BPD were enrolled. Intragastric pH was continuously monitored on the day before steroid treatment and on the four following days, initially without H2 blockade and then using a continuous intravenous infusion of ranitidine at 0.031, 0.0625, and 0.125 mg/kg/hour. An infusion of 0.0625 mg/kg/hour of ranitidine was sufficient to increase and maintain gastric pH above 4; the authors therefore use this infusion during dexamethasone administration as possible prevention of gastric perforation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chhattriwalla Y., Colon A. R., Scanlon J. W. The use of cimetidine in the newborn. Pediatrics. 1980 Feb;65(2):301–302. [PubMed] [Google Scholar]
  2. Gale S. M., Read L. C., George-Nascimento C., Wallace J. C., Ballard F. J. Is dietary epidermal growth factor absorbed by premature human infants? Biol Neonate. 1989;55(2):104–110. doi: 10.1159/000242903. [DOI] [PubMed] [Google Scholar]
  3. Herbst J. J., Minton S. D., Book L. S. Gastroesophageal reflux causing respiratory distress and apnea in newborn infants. J Pediatr. 1979 Nov;95(5 Pt 1):763–768. doi: 10.1016/s0022-3476(79)80733-7. [DOI] [PubMed] [Google Scholar]
  4. Hyman P. E., Clarke D. D., Everett S. L., Sonne B., Stewart D., Harada T., Walsh J. H., Taylor I. L. Gastric acid secretory function in preterm infants. J Pediatr. 1985 Mar;106(3):467–471. doi: 10.1016/s0022-3476(85)80682-x. [DOI] [PubMed] [Google Scholar]
  5. Lacroix J., Infante-Rivard C., Gauthier M., Rousseau E., van Doesburg N. Upper gastrointestinal tract bleeding acquired in a pediatric intensive care unit: prophylaxis trial with cimetidine. J Pediatr. 1986 Jun;108(6):1015–1018. doi: 10.1016/s0022-3476(86)80952-0. [DOI] [PubMed] [Google Scholar]
  6. Ng P. C., Brownlee K. G., Dear P. R. Gastroduodenal perforation in preterm babies treated with dexamethasone for bronchopulmonary dysplasia. Arch Dis Child. 1991 Oct;66(10 Spec No):1164–1166. doi: 10.1136/adc.66.10_spec_no.1164. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. O'Neil E. A., Chwals W. J., O'Shea M. D., Turner C. S. Dexamethasone treatment during ventilator dependency: possible life threatening gastrointestinal complications. Arch Dis Child. 1992 Jan;67(1 Spec No):10–11. doi: 10.1136/adc.67.1_spec_no.10. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Puntis J. W., Berg J. D., Buckley B. M., Booth I. W., McNeish A. S. Simplified oral pancreatic function test. Arch Dis Child. 1988 Jul;63(7):780–784. doi: 10.1136/adc.63.7.780. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Rogers M. J., Holmfield J. H., Primrose J. N., Johnston D. The effects of 15 days of dosing with placebo, sufotidine 600 mg nocte or sufotidine 600 mg twice daily upon 24-hour intragastric acidity and 24-hour plasma gastrin. Aliment Pharmacol Ther. 1990;4 (Suppl 1):65–74. [PubMed] [Google Scholar]
  10. Sondheimer J. M., Clark D. A., Gervaise E. P. Continuous gastric pH measurement in young and older healthy preterm infants receiving formula and clear liquid feedings. J Pediatr Gastroenterol Nutr. 1985 Jun;4(3):352–355. doi: 10.1097/00005176-198506000-00005. [DOI] [PubMed] [Google Scholar]
  11. Walker S., Klotz U., Sarem-Aslani A., Treiber G., Bode J. C. Effect of omeprazole on nocturnal intragastric pH in cirrhotics with inadequate antisecretory response to ranitidine. Digestion. 1991;48(3):179–184. doi: 10.1159/000200691. [DOI] [PubMed] [Google Scholar]
  12. Witzel L., Halter F., Olah A. J., Häcki W. H. Effects of prolonged metiamide medication on the fundic mucosa. A secretory and histomorphometric study in the rat. Gastroenterology. 1977 Oct;73(4 Pt 1):797–803. [PubMed] [Google Scholar]

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