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. 1993 Nov;69(5):573–576. doi: 10.1136/adc.69.5.573

Mycoplasma pneumoniae infection and neurological disease.

N H Thomas 1, J E Collins 1, S A Robb 1, R O Robinson 1
PMCID: PMC1029621  PMID: 8257178

Abstract

The cases are reported of 13 children seen over a 22 month period who presented with a variety of acute neurological illnesses associated with Mycoplasma pneumoniae infection. Although presentation with a decreased level of consciousness or seizures was common, psychosis, hemiparesis, cranial nerve palsies, and Guillain-Barré syndrome were also seen. In contrast with published reports, only one child had an associated chest infection. Although some children have been left with residual disability, most have made a complete recovery. In this recent experience, M pneumoniae is a not rare cause of neurological illness in childhood and may present in unusual ways.

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Selected References

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  1. Abramovitz P., Schvartzman P., Harel D., Lis I., Naot Y. Direct invasion of the central nervous system by Mycoplasma pneumoniae: a report of two cases. J Infect Dis. 1987 Mar;155(3):482–487. doi: 10.1093/infdis/155.3.482. [DOI] [PubMed] [Google Scholar]
  2. Al-Mateen M., Gibbs M., Dietrich R., Mitchell W. G., Menkes J. H. Encephalitis lethargica-like illness in a girl with mycoplasma infection. Neurology. 1988 Jul;38(7):1155–1158. doi: 10.1212/wnl.38.7.1155. [DOI] [PubMed] [Google Scholar]
  3. Ali N. J., Sillis M., Andrews B. E., Jenkins P. F., Harrison B. D. The clinical spectrum and diagnosis of Mycoplasma pneumoniae infection. Q J Med. 1986 Mar;58(227):241–251. [PubMed] [Google Scholar]
  4. Biberfeld G. Antibodies to brain and other tissues in cases of Mycoplasma pneumoniae infection. Clin Exp Immunol. 1971 Feb;8(2):319–333. [PMC free article] [PubMed] [Google Scholar]
  5. Carstensen H., Nilsson K. O. Neurological complications associated with Mycoplasma pneumoniae infection in children. Neuropediatrics. 1987 Feb;18(1):57–58. doi: 10.1055/s-2008-1052438. [DOI] [PubMed] [Google Scholar]
  6. Cassell G. H., Cole B. C. Mycoplasmas as agents of human disease. N Engl J Med. 1981 Jan 8;304(2):80–89. doi: 10.1056/NEJM198101083040204. [DOI] [PubMed] [Google Scholar]
  7. Clyde W. A., Jr Neurological syndromes and mycoplasmal infections. Arch Neurol. 1980 Feb;37(2):65–66. doi: 10.1001/archneur.1980.00500510023001. [DOI] [PubMed] [Google Scholar]
  8. Dalton M., Newton R. W. Aseptic meningitis. Dev Med Child Neurol. 1991 May;33(5):446–451. doi: 10.1111/j.1469-8749.1991.tb14905.x. [DOI] [PubMed] [Google Scholar]
  9. Hodges G. R., Fass R. J., Saslaw S. Central nervous system disease associated with Mycoplasma pneumoniae infection. Arch Intern Med. 1972 Aug;130(2):277–282. [PubMed] [Google Scholar]
  10. Hodges G. R., Perkins R. L. Landry-Guillain-Barré syndrome associated with Mycoplasma pneumoniae infection. JAMA. 1969 Dec 15;210(11):2088–2090. [PubMed] [Google Scholar]
  11. Kasahara I., Otsubo Y., Yanase T., Oshima H., Ichimaru H., Nakamura M. Isolation and characterization of Mycoplasma pneumoniae from cerebrospinal fluid of a patient with pneumonia and meningoencephalitis. J Infect Dis. 1985 Oct;152(4):823–825. doi: 10.1093/infdis/152.4.823. [DOI] [PubMed] [Google Scholar]
  12. Kennedy C. R., Chrzanowska K., Robinson R. O., Tyrrell D. A., Valman H. B., Webster A. D. A major role for viruses in acute childhood encephalopathy. Lancet. 1986 May 3;1(8488):989–991. doi: 10.1016/s0140-6736(86)91268-7. [DOI] [PubMed] [Google Scholar]
  13. Lehtokoski-Lehtiniemi E., Koskiniemi M. L. Mycoplasma pneumoniae encephalitis: a severe entity in children. Pediatr Infect Dis J. 1989 Sep;8(9):651–653. doi: 10.1097/00006454-198909000-00021. [DOI] [PubMed] [Google Scholar]
  14. Lerer R. J., Kalavsky S. M. Central nervous system disease associated with Mycoplasma pneumoniae infection: report of five cases and review of the literature. Pediatrics. 1973 Nov;52(5):658–668. [PubMed] [Google Scholar]
  15. MacFarlane P. I., Miller V. Transverse myelitis associated with Mycoplasma pneumoniae infection. Arch Dis Child. 1984 Jan;59(1):80–82. doi: 10.1136/adc.59.1.80. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Parker P., Puck J., Fernandez F. Cerebral infarction associated with Mycoplasma pneumoniae. Pediatrics. 1981 Mar;67(3):373–375. [PubMed] [Google Scholar]
  17. Rothstein T. L., Kenny G. E. Cranial neuropathy, myeloradiculopathy, and myositis: complications of Mycoplasma pneumoniae infection. Arch Neurol. 1979 Aug;36(8):476–477. doi: 10.1001/archneur.1979.00500440046007. [DOI] [PubMed] [Google Scholar]
  18. Sillis M. The limitations of IgM assays in the serological diagnosis of Mycoplasma pneumoniae infections. J Med Microbiol. 1990 Dec;33(4):253–258. doi: 10.1099/00222615-33-4-253. [DOI] [PubMed] [Google Scholar]
  19. Thomas L., Aleu F., Bitensky M. W., Davidson M., Gesner B. Studies of PPLO infection. II. The neurotoxin of Mycoplasma neurolyticum. J Exp Med. 1966 Dec 1;124(6):1067–1082. doi: 10.1084/jem.124.6.1067. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Thomas L., Davidson M., McCluskey R. T. Studies of PPLO infection. I. The production of cerebral polyarteritis by Mycoplasma gallisepticum in turkeys; the neurotoxic property of the Mycoplasma. J Exp Med. 1966 May 1;123(5):897–912. doi: 10.1084/jem.123.5.897. [DOI] [PMC free article] [PubMed] [Google Scholar]

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