Skip to main content
PMC home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1989 Sep;52(9):1068–1071. doi: 10.1136/jnnp.52.9.1068

Complex partial status epilepticus associated with cyclosporin A therapy.

R E Appleton 1, K Farrell 1, P Teal 1, S A Hashimoto 1, P K Wong 1
PMCID: PMC1031742  PMID: 2507748

Abstract

Significant neurotoxicity including seizures, encephalopathy and coma may complicate the use of cyclosporin A (CyA). Two patients are described, receiving CyA, who presented with abnormal behaviour, stupor, focal motor activity and were shown to be in complex partial status epilepticus (CPSE). Abnormalities of behaviour and/or stupor in patients receiving CyA may be a manifestation of CPSE. Patients receiving CyA who develop an encephalopathy should have electroencephalography performed at the time of the abnormal behaviour.

Full text

PDF
1069

Images in this article

1069Image
on p.1069

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atkinson K., Biggs J., Darveniza P., Boland J., Concannon A., Dodds A. Cyclosporine-associated central-nervous-system toxicity after allogeneic bone-marrow transplantation. N Engl J Med. 1984 Feb 23;310(8):527–527. doi: 10.1056/NEJM198402233100815. [DOI] [PubMed] [Google Scholar]
  2. Beaman M., Parvin S., Veitch P. S., Walls J. Convulsions associated with cyclosporin A in renal transplant recipients. Br Med J (Clin Res Ed) 1985 Jan 12;290(6462):139–140. doi: 10.1136/bmj.290.6462.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Berden J. H., Hoitsma A. J., Merx J. L., Keyser A. Severe central-nervous-system toxicity associated with cyclosporin. Lancet. 1985 Jan 26;1(8422):219–220. doi: 10.1016/s0140-6736(85)92053-7. [DOI] [PubMed] [Google Scholar]
  4. Durrant S., Chipping P. M., Palmer S., Gordon-Smith E. C. Cyclosporin A, methylprednisolone, and convulsions. Lancet. 1982 Oct 9;2(8302):829–830. doi: 10.1016/s0140-6736(82)92727-1. [DOI] [PubMed] [Google Scholar]
  5. Engel J., Jr, Ludwig B. I., Fetell M. Prolonged partial complex status epilepticus: EEG and behavioral observations. Neurology. 1978 Sep;28(9 Pt 1):863–869. doi: 10.1212/wnl.28.9.863. [DOI] [PubMed] [Google Scholar]
  6. Joss D. V., Barrett A. J., Kendra J. R., Lucas C. F., Desai S. Hypertension and convulsions in children receiving cyclosporin A. Lancet. 1982 Apr 17;1(8277):906–906. doi: 10.1016/s0140-6736(82)92171-7. [DOI] [PubMed] [Google Scholar]
  7. Kunzendorf U., Brockmöller J., Jochimsen F., Keller F., Walz G., Offermann G. Cyclosporin metabolites and central-nervous-system toxicity. Lancet. 1988 May 28;1(8596):1223–1223. doi: 10.1016/s0140-6736(88)92037-5. [DOI] [PubMed] [Google Scholar]
  8. Polson R. J., Powell-Jackson P. R., Williams R. Convulsions associated with cyclosporin A in transplant recipients. Br Med J (Clin Res Ed) 1985 Mar 30;290(6473):1003–1003. doi: 10.1136/bmj.290.6473.1003-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Rubin A. M., Kang H. Cerebral blindness and encephalopathy with cyclosporin A toxicity. Neurology. 1987 Jun;37(6):1072–1076. doi: 10.1212/wnl.37.6.1072. [DOI] [PubMed] [Google Scholar]
  10. Shah D., Rylance P. B., Rogerson M. E., Bewick M., Parsons V. Generalised epileptic fits in renal transplant recipients given cyclosporin A. Br Med J (Clin Res Ed) 1984 Nov 17;289(6455):1347–1348. doi: 10.1136/bmj.289.6455.1347. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Thompson C. B., June C. H., Sullivan K. M., Thomas E. D. Association between cyclosporin neurotoxicity and hypomagnesaemia. Lancet. 1984 Nov 17;2(8412):1116–1120. doi: 10.1016/s0140-6736(84)91556-3. [DOI] [PubMed] [Google Scholar]
  12. Treiman D. M., Delgado-Escueta A. V. Complex partial status epilepticus. Adv Neurol. 1983;34:69–81. [PubMed] [Google Scholar]
  13. Velu T., Debusscher L., Stryckmans P. A. Cyclosporin-associated fatal convulsions. Lancet. 1985 Jan 26;1(8422):219–219. doi: 10.1016/s0140-6736(85)92052-5. [DOI] [PubMed] [Google Scholar]
  14. Wilczek H., Ringden O., Tyden G. Cyclosporine-associated central nervous system toxicity after renal transplantation. Transplantation. 1985 Jan;39(1):110–110. doi: 10.1097/00007890-198501000-00022. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES