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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1989 Sep;52(9):1085–1089. doi: 10.1136/jnnp.52.9.1085

The incidence and mortality of multiple sclerosis in south east Wales.

A Hennessy 1, R J Swingler 1, D A Compston 1
PMCID: PMC1031745  PMID: 2795079

Abstract

The incidence of multiple sclerosis was shown to be 8.2/10(5)/year (definite or probable 5.4 and suspected 2.8/10(5)/year) during a 3 year prospective study carried out in an area of south east Wales which has a high prevalence of the disease (120/10(5). Mortality in affected individuals who were prevalent at the start of the survey was 3.1/10(5)/year; many deaths resulted from direct complications of multiple sclerosis but 38% were due to unrelated causes. The rate at which new cases were identified approximately matched deletions from the register arising from death, outward migration and other causes so that prevalence did not change significantly during the survey (1985-1988).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cook S. D., Cromarty J. I., Tapp W., Poskanzer D., Walker J. D., Dowling P. C. Declining incidence of multiple sclerosis in the Orkney Islands. Neurology. 1985 Apr;35(4):545–551. doi: 10.1212/wnl.35.4.545. [DOI] [PubMed] [Google Scholar]
  2. Downie A. W., Phadke J. G. The chief scientist reports ... multiple sclerosis in North East Scotland. Health Bull (Edinb) 1984 May;42(3):151–156. [PubMed] [Google Scholar]
  3. Hammond S. R., English D. R., de Wytt C., Hallpike J. F., Millingen K. S., Stewart-Wynne E. G., McLeod J. G., McCall M. G. The contribution of mortality statistics to the study of multiple sclerosis in Australia. J Neurol Neurosurg Psychiatry. 1989 Jan;52(1):1–7. doi: 10.1136/jnnp.52.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hammond S. R., McLeod J. G., Millingen K. S., Stewart-Wynne E. G., English D., Holland J. T., McCall M. G. The epidemiology of multiple sclerosis in three Australian cities: Perth, Newcastle and Hobart. Brain. 1988 Feb;111(Pt 1):1–25. doi: 10.1093/brain/111.1.1. [DOI] [PubMed] [Google Scholar]
  5. Poser C. M., Paty D. W., Scheinberg L., McDonald W. I., Davis F. A., Ebers G. C., Johnson K. P., Sibley W. A., Silberberg D. H., Tourtellotte W. W. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol. 1983 Mar;13(3):227–231. doi: 10.1002/ana.410130302. [DOI] [PubMed] [Google Scholar]
  6. Poskanzer D. C., Prenney L. B., Sheridan J. L., Kondy J. Y. Multiple sclerosis in the Orkney and Shetland Islands. I: Epidemiology, clinical factors, and methodology. J Epidemiol Community Health. 1980 Dec;34(4):229–239. doi: 10.1136/jech.34.4.229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. SUTHERLAND J. M. Observations on the prevalence of multiple sclerosis in Northern Scotland. Brain. 1956 Dec;79(4):635–654. doi: 10.1093/brain/79.4.635. [DOI] [PubMed] [Google Scholar]
  8. Shepherd D. I., Downie A. W. Prevalence of multiple sclerosis in north-east Scotland. Br Med J. 1978 Jul 29;2(6133):314–316. doi: 10.1136/bmj.2.6133.314. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Swingler R. J., Compston D. A. The prevalence of multiple sclerosis in south east Wales. J Neurol Neurosurg Psychiatry. 1988 Dec;51(12):1520–1524. doi: 10.1136/jnnp.51.12.1520. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Swingler R. J., Compston D. The distribution of multiple sclerosis in the United Kingdom. J Neurol Neurosurg Psychiatry. 1986 Oct;49(10):1115–1124. doi: 10.1136/jnnp.49.10.1115. [DOI] [PMC free article] [PubMed] [Google Scholar]

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