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. 1989 Jun;52(6):749–754. doi: 10.1136/jnnp.52.6.749

Electrophysiological and MRI evaluation of neurological involvement in Behçet's disease.

C Besana 1, G Comi 1, A Del Maschio 1, L Praderio 1, A Vergani 1, S Medaglini 1, V Martinelli 1, F Triulzi 1, T Locatelli 1
PMCID: PMC1032027  PMID: 2746268

Abstract

Eight patients with stable Behçet's disease were studied by means of multimodality evoked potentials and magnetic resonance imaging to evaluate the possibility of an earlier and objective demonstration of clinical and subclinical Central Nervous System (CNS) involvement. It was shown that both diagnostic techniques are useful for quantitative evaluation of neurological involvement in Behçet's disease; of particular interest was the demonstration of subclinical CNS changes.

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Selected References

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  1. Abdalla M. I., el-D Bahoat N. Long-lasting remission of Behcet's disease after chlorambucil therapy. Br J Ophthalmol. 1973 Sep;57(9):706–711. doi: 10.1136/bjo.57.9.706. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Awad I. A., Spetzler R. F., Hodak J. A., Awad C. A., Carey R. Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. I. Correlation with age and cerebrovascular risk factors. Stroke. 1986 Nov-Dec;17(6):1084–1089. doi: 10.1161/01.str.17.6.1084. [DOI] [PubMed] [Google Scholar]
  3. Awad I., Modic M., Little J. R., Furlan A. J., Weinstein M. Focal parenchymal lesions in transient ischemic attacks: correlation of computed tomography and magnetic resonance imaging. Stroke. 1986 May-Jun;17(3):399–403. doi: 10.1161/01.str.17.3.399. [DOI] [PubMed] [Google Scholar]
  4. Chajek T., Fainaru M. Behçet's disease. Report of 41 cases and a review of the literature. Medicine (Baltimore) 1975 May;54(3):179–196. doi: 10.1097/00005792-197505000-00001. [DOI] [PubMed] [Google Scholar]
  5. Dobkin B. H. Computerized tomographic findings in neuro-Behcet's disease. Arch Neurol. 1980 Jan;37(1):58–59. doi: 10.1001/archneur.1980.00500500088017. [DOI] [PubMed] [Google Scholar]
  6. EVANS A. D., PALLIS C. A., SPILLANE J. D. Involvement of the nervous system in Behçet's syndrome; report of three cases and isolation of virus. Lancet. 1957 Aug 24;273(6991):349–353. doi: 10.1016/s0140-6736(57)92589-8. [DOI] [PubMed] [Google Scholar]
  7. Empey D. W., Hale J. E. Rectal and colonic ulceration in Behcet's disease. Proc R Soc Med. 1972 Feb;65(2):163–164. [PMC free article] [PubMed] [Google Scholar]
  8. Kansu E., Ozer F. L., Akalin E., Güler Y., Zileli T., Tanman E., Kaplaman E., Müftüoğlu E. Behçet's syndrome with obstruction of the venae cavae. A report of seven cases. Q J Med. 1972 Apr;41(162):151–168. [PubMed] [Google Scholar]
  9. Kozin F., Haughton V., Bernhard G. C. Neuro-Behcet disease: two cases and neuroradiologic findings. Neurology. 1977 Dec;27(12):1148–1152. doi: 10.1212/wnl.27.12.1148. [DOI] [PubMed] [Google Scholar]
  10. Mason R. M., Barnes C. G. Behçet's syndrome with arthritis. Ann Rheum Dis. 1969 Mar;28(2):95–103. doi: 10.1136/ard.28.2.95. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. McMENEMEY W. H., LAWRENCE B. J. Encephalomyelopathy in Becket's disease; report of necropsy findings in two cases. Lancet. 1957 Aug 24;273(6991):353–358. doi: 10.1016/s0140-6736(57)92590-4. [DOI] [PubMed] [Google Scholar]
  12. Miller D. H., Ormerod I. E., Gibson A., du Boulay E. P., Rudge P., McDonald W. I. MR brain scanning in patients with vasculitis: differentiation from multiple sclerosis. Neuroradiology. 1987;29(3):226–231. doi: 10.1007/BF00451758. [DOI] [PubMed] [Google Scholar]
  13. Nussenblatt R. B., Palestine A. G., Chan C. C., Mochizuki M., Yancey K. Effectiveness of cyclosporin therapy for Behçet's disease. Arthritis Rheum. 1985 Jun;28(6):671–679. doi: 10.1002/art.1780280611. [DOI] [PubMed] [Google Scholar]
  14. O'Duffy J. D., Goldstein N. P. Neurologic involvement in seven patients with Behçet's disease. Am J Med. 1976 Aug;61(2):170–178. doi: 10.1016/0002-9343(76)90166-2. [DOI] [PubMed] [Google Scholar]
  15. O'Duffy J. D., Robertson D. M., Goldstein N. P. Chlorambucil in the treatment of uveitis and meningoencephalitis of Behçet's disease. Am J Med. 1984 Jan;76(1):75–84. doi: 10.1016/0002-9343(84)90753-8. [DOI] [PubMed] [Google Scholar]
  16. Ormerod I. E., Roberts R. C., du Boulay E. P., McDonald W. I., Callanan M. M., Halliday A. M., Johnson G., Kendall B. E., Logsdail S. J., Macmanus D. G. NMR in multiple sclerosis and cerebral vascular disease. Lancet. 1984 Dec 8;2(8415):1334–1335. doi: 10.1016/s0140-6736(84)90836-5. [DOI] [PubMed] [Google Scholar]
  17. Rosselet E., Saudan Y., Zenklusen G. Les effets de l'azathioprine ("Imuran") dans la maladie de Behçet. Premiers résultats thérapeutiques. Ophthalmologica. 1968;156(3):218–226. doi: 10.1159/000305426. [DOI] [PubMed] [Google Scholar]
  18. SCHOTLAND D. L., WOLF S. M., WHITE H. H., DUBIN H. V. Neurologic aspects of Behcet's disease. Case report and review of the literature. Am J Med. 1963 Apr;34:544–553. doi: 10.1016/0002-9343(63)90078-0. [DOI] [PubMed] [Google Scholar]
  19. STROUTH J. C., DYKEN M. ENCEPHALOPATHY OF BEHCET'S DISEASE. REPORT OF A CASE. Neurology. 1964 Sep;14:794–805. doi: 10.1212/wnl.14.9.794. [DOI] [PubMed] [Google Scholar]
  20. Sobel J. D., Haim S., Shafrir A., Gellei B. Cutaneous hyperreactivity in Behçet's disease. Dermatologica. 1973;146(6):350–356. doi: 10.1159/000251993. [DOI] [PubMed] [Google Scholar]
  21. WHITTY C. W. Neurologic implications of Behcet's syndrome. Neurology. 1958 May;8(5):369–373. doi: 10.1212/wnl.8.5.369. [DOI] [PubMed] [Google Scholar]
  22. WOLF S. M., SCHOTLAND D. L., PHILLIPS L. L. INVOLVEMENT OF NERVOUS SYSTEM IN BEHCET'S SYNDROME. Arch Neurol. 1965 Mar;12:315–325. doi: 10.1001/archneur.1965.00460270091012. [DOI] [PubMed] [Google Scholar]
  23. Wechsler B., Mertani E. B., le Hoang P., de Groc F., Piette J. C., Beaufils H., Aupetit B., le Minh H., Rottembourg J. Cyclosporin A is effective, but not safe, in the management of Behçet's disease. Arthritis Rheum. 1986 Apr;29(4):574–575. doi: 10.1002/art.1780290420. [DOI] [PubMed] [Google Scholar]
  24. Willeit J., Schmutzhard E., Aichner F., Mayr U., Weber F., Gerstenbrand F. CT and MR imaging in neuro-Behçet disease. J Comput Assist Tomogr. 1986 Mar-Apr;10(2):313–315. doi: 10.1097/00004728-198603000-00027. [DOI] [PubMed] [Google Scholar]
  25. Williams A. L., Haughton V. M., Saxena V. K., Albers J. W. Computed tomography in Behçet disease. Radiology. 1979 May;131(2):403–404. doi: 10.1148/131.2.403. [DOI] [PubMed] [Google Scholar]

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