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. 1987 Nov;50(11):1522–1525. doi: 10.1136/jnnp.50.11.1522

Meige syndrome: double-blind crossover study of sodium valproate.

J W Snoek 1, T W van Weerden 1, A W Teelken 1, W van den Burg 1, J P Lakke 1
PMCID: PMC1032567  PMID: 3121795

Abstract

A double-blind crossover study of sodium valproate and placebo was conducted in five patients with Meige syndrome. CSF neurotransmitter studies were performed at the end of each treatment period. GABA levels were not influenced by the administration of sodium valproate. An increase in HVA levels was observed in every patient, which may reflect an increase in central dopaminergic activity. This finding may explain the trend towards clinical deterioration which was observed during treatment with sodium valproate. Sodium valproate appears to be ineffective in Meige syndrome.

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Selected References

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