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. 1988 Jan;51(1):28–34. doi: 10.1136/jnnp.51.1.28

Quantitative objective assessment of peripheral nociceptive C fibre function.

N Parkhouse 1, P M Le Quesne 1
PMCID: PMC1032710  PMID: 3351528

Abstract

A technique is described for the quantitative assessment of peripheral nociceptive C fibre function by measurement of the axon reflex flare. Acetylcholine, introduced by electrophoresis, is used to stimulate a ring of nociceptive C fibre endings at the centre of which the increase in blood flow is measured with a laser Doppler flowmeter. This flare (neurogenic vasodilatation) has been compared with mechanically or chemically stimulated non-neurogenic cutaneous vasodilation. The flare is abolished by local anaesthetic and is absent in denervated skin. The flare has been measured on the sole of the foot of 96 healthy subjects; its size decreases with age in males, but not in females.

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Selected References

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  1. BONNEY G., GILLIATT R. W. Sensory nerve conduction after traction lesion of the brachial plexus. Proc R Soc Med. 1958 May;51(5):365–367. [PMC free article] [PubMed] [Google Scholar]
  2. BONNEY G. The value of axon responses in determining the site of lesion in traction injuries of the brachial plexus. Brain. 1954 Dec;77(4):588–609. doi: 10.1093/brain/77.4.588. [DOI] [PubMed] [Google Scholar]
  3. Bertelsmann F. W., Heimans J. J., Weber E. J., van der Veen E. A., Schouten J. A. Thermal discrimination thresholds in normal subjects and in patients with diabetic neuropathy. J Neurol Neurosurg Psychiatry. 1985 Jul;48(7):686–690. doi: 10.1136/jnnp.48.7.686. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bloom S., Till S., Sönksen P., Smith S. Use of a biothesiometer to measure individual vibration thresholds and their variation in 519 non-diabetic subjects. Br Med J (Clin Res Ed) 1984 Jun 16;288(6433):1793–1795. doi: 10.1136/bmj.288.6433.1793. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Carpenter S. E., Lynn B. Vascular and sensory responses of human skin to mild injury after topical treatment with capsaicin. Br J Pharmacol. 1981 Jul;73(3):755–758. doi: 10.1111/j.1476-5381.1981.tb16812.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Crawford P. M., West C. R., Chadwick D. W., Shaw M. D. Arteriovenous malformations of the brain: natural history in unoperated patients. J Neurol Neurosurg Psychiatry. 1986 Jan;49(1):1–10. doi: 10.1136/jnnp.49.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. DOUGLAS W. W., RITCHIE J. M. The excitatory action of acetylcholine on cutaneous non-myelinated fibres. J Physiol. 1960 Mar;150:501–514. doi: 10.1113/jphysiol.1960.sp006401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Duncan H. J., Faris I. B., DeYoung N. J. The effectiveness of local injections of vasodilating agents to produce vasodilation in subcutaneous tissue in rabbits. Clin Physiol. 1985 Feb;5(1):71–80. doi: 10.1111/j.1475-097x.1985.tb00748.x. [DOI] [PubMed] [Google Scholar]
  9. Foreman J. C. Peptides and neurogenic inflammation. Br Med Bull. 1987 Apr;43(2):386–400. doi: 10.1093/oxfordjournals.bmb.a072189. [DOI] [PubMed] [Google Scholar]
  10. Fruhstorfer H., Lindblom U., Schmidt W. C. Method for quantitative estimation of thermal thresholds in patients. J Neurol Neurosurg Psychiatry. 1976 Nov;39(11):1071–1075. doi: 10.1136/jnnp.39.11.1071. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hutchison K. J., Johnson B. W., Williams H. T., Brown G. D. The histamine flare response in diabetes mellitus. Surg Gynecol Obstet. 1974 Oct;139(4):566–568. [PubMed] [Google Scholar]
  12. Jamal G. A., Hansen S., Weir A. I., Ballantyne J. P. An improved automated method for the measurement of thermal thresholds. 1. Normal subjects. J Neurol Neurosurg Psychiatry. 1985 Apr;48(4):354–360. doi: 10.1136/jnnp.48.4.354. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Jancsó G., Husz S., Simon N. Impairment of axon reflex vasodilatation after herpes zoster. Clin Exp Dermatol. 1983 Jan;8(1):27–31. doi: 10.1111/j.1365-2230.1983.tb01740.x. [DOI] [PubMed] [Google Scholar]
  14. MOORE J. M., FREW I. D. PERIPHERAL VASCULAR LESION IN DIABETES MELLITUS. Br Med J. 1965 Jul 3;2(5452):19–23. doi: 10.1136/bmj.2.5452.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. O'Sullivan D. J., Swallow M. The fibre size and content of the radial and sural nerves. J Neurol Neurosurg Psychiatry. 1968 Oct;31(5):464–470. doi: 10.1136/jnnp.31.5.464. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. SMITH A. A., DANCIS J. RESPONSE TO INTRADERMAL HISTAMINE IN FAMILIAL DYSAUTONOMIA--A DIAGNOSTIC TEST. J Pediatr. 1963 Nov;63:889–894. doi: 10.1016/s0022-3476(63)80219-x. [DOI] [PubMed] [Google Scholar]
  17. STEINESS I. Vibratory perception in normal subjects; a biothesiometric study. Acta Med Scand. 1957 Sep 20;158(5):315–325. doi: 10.1111/j.0954-6820.1957.tb15496.x. [DOI] [PubMed] [Google Scholar]
  18. Tooke J. E., Ostergren J., Fagrell B. Synchronous assessment of human skin microcirculation by laser Doppler flowmetry and dynamic capillaroscopy. Int J Microcirc Clin Exp. 1983;2(4):277–284. [PubMed] [Google Scholar]
  19. Torebjörk H. E., Hallin R. G. Identification of afferent C units in intact human skin nerves. Brain Res. 1974 Mar 8;67(3):387–403. doi: 10.1016/0006-8993(74)90489-2. [DOI] [PubMed] [Google Scholar]
  20. Zotterman Y. Touch, pain and tickling: an electro-physiological investigation on cutaneous sensory nerves. J Physiol. 1939 Feb 14;95(1):1–28. doi: 10.1113/jphysiol.1939.sp003707. [DOI] [PMC free article] [PubMed] [Google Scholar]

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