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. 1988 Sep;51(9):1142–1145. doi: 10.1136/jnnp.51.9.1142

Improvement of muscle strength in familial hypokalaemic periodic paralysis with acetazolamide.

T P Links 1, M J Zwarts 1, H J Oosterhuis 1
PMCID: PMC1033016  PMID: 3066848

Abstract

A double blind cross-over study of eight patients with familial hypokalaemic periodic paralysis was made to assess the influence of acetazolamide on muscle strength. All patients had a reduced interictal muscle fibre conduction velocity. Five patients had no attacks at the time of the study. One patient withdrew from the study because of an adverse reaction. The muscle strength of 11 muscle groups was measured with a hand-held dynamometer. The sum of force improved significantly in the seven patients (mean increase: 17%, p less than 0.05; 95% confidence interval: 7.2-26.8%). Endurance tests showed an improvement in the performance of 30 full kneebends. Surface EMG measurement showed no change in the muscle fibre conduction velocity or power spectra during treatment. The integrated EMG showed a (non significant) mean increase of 21%.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Buruma O. J., Bots G. T., Went L. N. Familial hypokalemic periodic paralysis. 50-year follow-up of a large family. Arch Neurol. 1985 Jan;42(1):28–31. doi: 10.1001/archneur.1985.04060010034012. [DOI] [PubMed] [Google Scholar]
  2. Dalakas M. C., Engel W. K. Treatment of "permanent" muscle weakness in familial Hypokalemic Periodic Paralysis. Muscle Nerve. 1983 Mar-Apr;6(3):182–186. doi: 10.1002/mus.880060303. [DOI] [PubMed] [Google Scholar]
  3. Griggs R. C., Engel W. K., Resnick J. S. Acetazolamide treatment of hypokalemic periodic paralysis. Prevention of attacks and improvement of persistent weakness. Ann Intern Med. 1970 Jul;73(1):39–48. doi: 10.7326/0003-4819-73-1-39. [DOI] [PubMed] [Google Scholar]
  4. MAREN T. H., WADSWORTH B. C., YALE E. K., ALONSO L. G. Carbonic anhydrase inhibition. III. Effects of diamox on electrolyte metabolism. Bull Johns Hopkins Hosp. 1954 Dec;95(6):277–321. [PubMed] [Google Scholar]
  5. Naeije M., Zorn H. Estimation of the action potential conduction velocity in human skeletal muscle using the surface EMG cross-correlation technique. Electromyogr Clin Neurophysiol. 1983 Jan-Feb;23(1-2):73–80. [PubMed] [Google Scholar]
  6. PEARSON C. M. THE PERIODIC PARALYSES: DIFFERENTIAL FEATURES AND PATHOLOGICAL OBSERVATIONS IN PERMANENT MYOPATHIC WEAKNESS. Brain. 1964 Jun;87:341–354. doi: 10.1093/brain/87.2.341. [DOI] [PubMed] [Google Scholar]
  7. Rüdel R., Lehmann-Horn F., Ricker K., Küther G. Hypokalemic periodic paralysis: in vitro investigation of muscle fiber membrane parameters. Muscle Nerve. 1984 Feb;7(2):110–120. doi: 10.1002/mus.880070205. [DOI] [PubMed] [Google Scholar]
  8. Thompson A. J., Hutchinson M. Myopathy in hypokalaemic periodic paralysis: reversal with acetazolamide. Ir Med J. 1984 Jun;77(6):171–172. [PubMed] [Google Scholar]
  9. Zwarts M. J., van Weerden T. W., Links T. P., Haenen H. T., Oosterhuis H. J. The muscle fiber conduction velocity and power spectra in familial hypokalemic periodic paralysis. Muscle Nerve. 1988 Feb;11(2):166–173. doi: 10.1002/mus.880110213. [DOI] [PubMed] [Google Scholar]
  10. van der Ploeg R. J., Oosterhuis H. J., Reuvekamp J. Measuring muscle strength. J Neurol. 1984;231(4):200–203. doi: 10.1007/BF00313939. [DOI] [PubMed] [Google Scholar]

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